Category: 2103-99-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2103-99-3,4-(4-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

3,4-Dibutyryloxybenzoic acid (216 mg, 0.73 mmol) was dissolved in dichloromethane (5 mL). DMF (50 muL) and 2 M oxalyl chloride in CH2Cl2 (0.6 mL) were added to it at RT The mixture became a yellowish solution. After 0.5 hour stirring, the solvent was removed in vacuo. The residue was dissolved in dioxane (10 mL). 2-Amino-4-(4-chlorophenyl)thiazole (210 mg, 1.0 mmol) was added to it, followed by addition of pyridine (150 uL). The mixture was heated at 100¡ã C. for 1 hour. After cooling down to RT, the solvent was removed in vacuo. The residue was dissolved in EtOAc (50 mL) and washed with water (50 mL). The EtOAc solution was dried over sodium sulfate. After filtration and concentration, the residue was purified by chromatography eluted with CHCl3. The collected fractions were concentrated and purified again by chromatotron (silica) eluted with CHCl3 to afford the product (120 mg, Y=34percent). 1H NMR (CDCl3) delta 10.01 (bs, 1 H), 7.70-7.80 (m, 4 H), 7.35 (d, J=8.7 Hz, 2 H), 7.30 (dd, J=8.44 Hz, J=1.8 Hz, 1 H), 7.18 (s, 1 H), 2.55 (t, d=7.5 Hz, 2 H), 2.54 (t, d=7.5 Hz, 2 H), 1.70-1.86 (m, 4 H), 1.06 (t, d=7.5 Hz, 3 H), 1.05 (t, d=75 Hz, 3 H); 13C NMR (CDCl3) delta 170.5, 170.2, 163.0, 158.2, 148.9, 145.7, 142.3, 133.7, 132.5, 130.0, 128.7 (2 C), 127.2 (2 C), 125.4, 123.9, 123.1, 108.5, 35.9, 35.8, 18.5, 18.4, 13.7 (2 C); MS (MALDI-TOF) m/z calcd for C24H24ClN2O5S (M+H+) 487, found 487., 2103-99-3

The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Apogee Biotechnology Corporation; US2007/32531; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2103-99-3, 4-(4-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 2-amino-4-phenylthiazole 6a (0.530 g, 3 mmol) and Et3N (560 muL, 4 mmol) in dichloromethane (15 mL) was cooled to 0-5 C in an ice-bath and stirred for 30 min. 2-Chloroacetyl chloride (578 muL, 6.6 mmol) in dry dichloromethane (1.5 mL) was then added slowly, and the reaction mixture was allowed to warm to room temperature and stirred until the amine was completely consumed (ca. 1 h, as monitored by TLC). The reaction mixture was diluted with dichloromethane and washed successively with water and saturated brine. The organic layer was dried over anhydrous Na2SO4, the solvent was removed under reduced pressure and the residue was recrystallised from ethanol to give compound 7a (0.413 g, 54percent) as light-grey crystals, mp 170-171 oC (Lit.18,20,26 171-173 oC). The remaining analogues were obtained similarly [7b (100percent) as a brown solid, mp 194-195 oC (Lit.27 mp not cited); 7c (64percent) as a brown solid, mp 241-243 oC (Lit.27 mp not cited); 7d (64percent) as a brown solid, mp 135-137 oC (Lit.28 135 oC); 7e (0.262 g, 88percent) as a yellow solid, mp 174-176 C (Lit.29 175 oC); 7f (70percent) as a light-brown solid, mp 213-216 oC (Lit.30 216 oC)., 2103-99-3

The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T.; Arkivoc; vol. 2018; 7; (2018); p. 110 – 118;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica