Category: 22900-83-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Weigh tert-butyl ((R)-2-hydroxy-2-phenylethyl) (4-((S)-pyrrolidine-2-carboxamido)phenethyl)carbamate (500 mg, 1.10 Mm),Ethyl 2-bromo-4-methyl-thiazole-5-carboxylate(330 mg, 1.32 mmol),Potassium carbonate (461 mg, 3.30 mmol) in a 100 mL single-mouth bottle,Add acetonitrile (15 mL) and start to reflux at 90 ¡ã C, and stop the reaction for 10 hours.The reaction mixture was concentrated, and the residue was purified by column chromatography ( petroleum ether/ethyl acetate (v/v) = 2/1)The title compound was obtained as a white solid(430 mg, 63percent).

22900-83-0, 22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhong Wenhe; Jin Chuanfei; Xu Tengfei; (45 pag.)CN109734712; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Part F: Ethyl 4-methyi-2-morpholin-4-yl-1.3-thiazole-5-carboxylate; A mixture of ethyl 2-bromo-4-methyl-ls3-thiazole-5-carboxylate (950 mg, 3.80 mmol), morpholine (0.5 mL, 5.70 mmol), and potassium carbonate (1.1 g, 7.60 mmol) in 4.0 ml of NMP is heated to 130 ¡ãC for 1.5 h. The reaction is cooled to RT, and the NMP is removed in vacuo. The residue is partitioned between CH1CI2 and water (20 ml each), and the layers are separated. The aqueous layer is extracted once more with 20 ml of CH2CI2, and the combined organic extracts are dried (Na2SQ4), filtered, and evaporated in vacuo to give the title compound as an off-white solid. Mass spec. (257.06, M+H)., 22900-83-0

22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROGEN CORPORATION; WO2008/83070; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

22900-83-0, Ethyl 2-bromo-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Fluorophenol (Sigma-Aldrich; 2 g; 17.84 mmol), ethyl 2-bromo-4-methylthiazole-5- carboxylate (Ark Pharm; 4 g; 16 mmol), and cesium carbonate (Sigma-Aldrich; 6.24 g; 19.15 mmol) were thoroughly mixed in 32 ml anhydrous dimethylsulfoxide, and the resulting slurry stirred vigorously 16 h at 45¡ãC. After cooling to 25¡ãC, the reaction mixture was poured into 200 ml water. Organics were extracted with 4×100 ml ether, and the pooled extracts were washed with 50 ml water, washed with 50 ml brine, dried over anhydrous sodium sulfate, filtered, and concentrated to 4.51 g brown solid. NMR showed the desired product, ethyl 2- (4-fluorophenoxy)-4-methylthiazole-5-carboxylate, which was used in the next step without further purification. Yield: 4.51 g (100percent).1H NMR (400 MHz, CDCb): d 7.21 (m, 2H), 7.05 (m, 2H), 4.28 (q, 2H),) 2.48 (s, 3H), 1.32 (t, 3H, 22900-83-0

22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; (72 pag.)WO2019/160873; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Tert-Butyl 4- (2-benzyl) -4 (trifluoromethyl) phenyl) piperazine-1-carboxylate(0. 52 g, 1.50 mmol),Bromo-4-methylthiocono-5-carboxylate (0.39 g, 1. 58 mmol) and potassium carbonate(0.42 g, 3. OO mmol) was addedDMSO (10 mL), and the reaction was allowed to warm to 110 ¡ã C for 20 hours.After completion of the reaction, the reaction solution was cooled to room temperature,And water (20 mL) was added thereto, followed by extraction with ethyl acetate (20 mLX3). The combined organic phases were dried over anhydrous sodium sulphateDried, filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 2/1)Afforded the title compound as a light yellow solid (0.35 g, 45.2percent)., 22900-83-0

The synthetic route of 22900-83-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian co ltd/Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian gongci; Jin, chuan Fei; Liang, Haiping; zhang, yingjun; Zhang, Ji; Kang, Ning; Li, Yong; Liu, Yan Ping; (38 pag.)CN105294554; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica