Category: 2346-00-1

2346-00-1, 2-Methyl-4,5-dihydrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2,4,4-Trimethyl-2-oxazoline 1 (1.50 g, 13.1 mmol, 1 eq.) was placed in a 100 mL flask, followed by dried THF (76 mL) and triethylamine (3.11 g, 30.6 mmol, 2.33 eq.). At ice bath temperature, (CF3CO)2O (6.52 g, 30.7 mmol, 2.34 eq.) was added dropwise over 23 min. The resulting suspension was refluxed for 5 h under nitrogen. Rotary evaporation was used to remove the solvent. Dichloromethane (30 mL) and saturated NaHCO3 (40 mL) were added to the residue and the mixture was stirred for 10 min. The organic layer was washed further with water (2 .x.40 mL). The organic layer was dried over anhydrous Na2SO4. After concentrating by rotary evaporation, the crude product was purified by flash column chromatography over silica gel, using mixed ethyl acetate/hexanes (2 : 1 volume ratio) as the eluting solvent. A white solid (1.34 g, 6.40 mmol) was obtained, yield 48.8percent.

2346-00-1, As the paragraph descriping shows that 2346-00-1 is playing an increasingly important role.

Reference：
Article; De Silva, Hondamuni I.; Song, Yingquan; Henry, William P.; Pittman Jr., Charles U.; Tetrahedron Letters; vol. 53; 24; (2012); p. 2965 – 2970;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-00-1,2-Methyl-4,5-dihydrothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 7 2-Methyl-1,3-thiazoline (1.32 g) and pyridine (2.37 g) were dissolved in dichloromethane (50 ml) and cooled in an ice-bath. Chlorodifluoroacetic anhydride (6.3 g) was added to the above solution, dropwise, over 30 minutes. The mixture was then allowed to attain ambient temperature over 18 hours. The solvent was evaporated off under reduced pressure and the residue was suspended in water (50 ml) and treated with solid sodium bicarbonate until the solution became basic. The mixture was extracted with dichloromethane (3 x 75 ml), and the combined organic extract was dried over magnesium sulphate. The solvent was removed under reduced pressure and the residue recrystallized from ethanol to give a solid (2.4 g), 2-(chlorodifluoromethylcarbonylmethylene)-1,3-thiazolidine. mp 99°C. This intermediate compound (1.15 g) was dissolved in dimethyl formamide (15 ml, dried) and cooled in an ice-bath, with stirring and under a nitrogen gas atmosphere.

2346-00-1, 2346-00-1 2-Methyl-4,5-dihydrothiazole 16867, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SHELL INTERNATIONALE RESEARCH, MAATSCHAPPIJ B.V.; EP652215; (1995); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2346-00-1, 2-Methyl-4,5-dihydrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(2-hydroxyethyl)-2-methylthiazolium bromide To a solution of 2-methylthiazoline (10.1 g) in dioxane (20 ml) was added 2-bromoethanol (13.8 g), and the mixture was heated under reflux for about 6 hours. After cooling the reaction, acetone (30 ml) and ether (130 ml) were added with stirring, and the resulting mixture was left standing. After the pale brown supernatant was discarded, ether (150 ml) was further added to the amorphous precipitate thus obtained. The mixture was stirred and left standing. Supernatant obtained was discarded, and the viscous precipitates obtained was left standing at an ambient temperature under reduced pressure to give the title compound as the yellow amorphous residue. Yield: 19.5 g. NMR (in DMSO-d6): delta4.51 (2H, t), 3.87 (2H, t), 3.72 (2H, t), 3.67 (2H, t), 2.61 (3H, s)., 2346-00-1

2346-00-1 2-Methyl-4,5-dihydrothiazole 16867, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Drug Delivery System Institute, Ltd.; US5580904; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2346-00-1, 2-Methyl-4,5-dihydrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 3-Methyl-2- [(3-methyl-2-thiazolidinylidene)-methyl]-5-phenylbenzoxazolium iodide A mixture of 2-(methylthio)-5-phenylbenzoxazole (14.5 g), 4,5-dihydro-2-methylthiazole (4.75 g), and methyl p-toluenesulphonate (28.0 g) was heated at 140C for four hours. Pyridine (50 ml) was added, and the mixture was refluxed for 40 minutes. The resulting solution was cooled and treated with water (100 ml), and the solid which separated was filtered off. The filtrate was treated with sodium iodide (30 g) and concentrated hydrochloric acid (50 ml). The precipitate was filtered off, washed with water, dried, warmed with toluene, and refiltered; it was finally crystallized from methanol to yield the product as pale yellow crystals, m.p. 262 – 264 C., 2346-00-1

The synthetic route of 2346-00-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ILFORD Limited; EP324717; (1989); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-00-1,2-Methyl-4,5-dihydrothiazole,as a common compound, the synthetic route is as follows.

2-Methyl-2-thiazoline 7 (16.57g, 162.1 mmol, 1 eq.) was placed in a 250 ml flask, followed by dried THF (75.6 mL) and CH3I (23.26 g, 162.2 mmol, 1 equiv). The flask was wrapped with aluminum foil and the mixture was stirred for 18 h at room temperature. White crystals of product 14 were filtered, washed with dried THF and vacuum-dried. 20.57 g (84.6 mmol) of 14 was obtained, yield 52.2percent. Melting point, 1H and 13C NMR spectroscopy data, and IR spectroscopy data are available in ref. 3., 2346-00-1

As the paragraph descriping shows that 2346-00-1 is playing an increasingly important role.

Reference：
Article; De Silva, Hondamuni I.; Song, Yingquan; Henry, William P.; Pittman Jr., Charles U.; Tetrahedron Letters; vol. 53; 24; (2012); p. 2965 – 2970;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica