Category: 24295-03-2

Johnson, Jino et al. published their research in Applied Organometallic Chemistry in 2022 |CAS: 24295-03-2

The Article related to cobalt nickel copper zinc thiazolyl chalcone complex preparation antimicrobial, photocatalysis dye degradation cobalt nickel copper zinc thiazolyl chalcone, mol structure calculation cobalt nickel copper zinc thiazolyl chalcone, dimethoxyphenyl thiazolyl propenone cobalt nickel copper zinc preparation antimicrobial and other aspects.Recommanded Product: 2-Acetylthiazole

On January 31, 2022, Johnson, Jino; Yardily, Amose published an article.Recommanded Product: 2-Acetylthiazole The title of the article was Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of chalcone: Synthesis, characterization, thermal, antimicrobial, photocatalytic degradation of dye and molecular modeling studies. And the article contained the following:

A thiazole-based chalcone ligand and its bidentate Co(II), Ni(II), Cu(II), and Zn(II) complexes of general formula [M(DMTP)2], (DMTP = (E)-3-(3,4-dimethoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one) have been synthesized. The compounds were characterized by elemental analyses, molar conductance, fourier-transform IR (FTIR) spectra, 1H NMR, 13C NMR, mass, UV-Vis., magnetic susceptibility, and thermal and powder x-ray diffraction (XRD) techniques. Based on spectral data, tetrahedral geometry is assigned for Co(II), Ni(II), and Zn(II) complexes. Square planar geometry was observed for Cu(II) complex. Mol. geometries of the compounds were fully optimized with d. functional theory (DFT) computations. Addnl., the Lewis base character of DMTP, flexibility toward metal ions, structural stabilization on coordination, frontier MOs (FMO), quantum chem. parameters, and theor. vibrational frequencies were evaluated. The antibacterial and antifungal (in vitro and in silico) activities of the complexes were studied and compared with those of DMTP. Finally, the metal(II) complexes of DMTP were successfully used to enhance the removal of methylene blue (MB) dye from an aqueous solution The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Recommanded Product: 2-Acetylthiazole

The Article related to cobalt nickel copper zinc thiazolyl chalcone complex preparation antimicrobial, photocatalysis dye degradation cobalt nickel copper zinc thiazolyl chalcone, mol structure calculation cobalt nickel copper zinc thiazolyl chalcone, dimethoxyphenyl thiazolyl propenone cobalt nickel copper zinc preparation antimicrobial and other aspects.Recommanded Product: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stevanovic, Nevena et al. published their research in Dalton Transactions in 2022 |CAS: 24295-03-2

The Article related to transition metal quaternary ammonium thiazolyl hydrazone complex preparation, crystal structure transition metal quaternary ammonium thiazolyl hydrazone complex, antimicrobial activity transition metal quaternary ammonium thiazolyl hydrazone complex, antitumor activity transition metal quaternary ammonium thiazolyl hydrazone complex and other aspects.Category: thiazole

Stevanovic, Nevena; Zlatar, Matija; Novakovic, Irena; Pevec, Andrej; Radanovic, Dusanka; Matic, Ivana Z.; Djordjic Crnogorac, Marija; Stanojkovic, Tatjana; Vujcic, Miroslava; Gruden, Maja; Sladic, Dusan; Andjelkovic, Katarina; Turel, Iztok; Cobeljic, Bozidar published an article in 2022, the title of the article was Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity.Category: thiazole And the article contains the following content:

Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal x-ray diffraction, IR spectroscopy, elemental anal. and DFT calculations In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear pentacoordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], resp., while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-neg. and Gram-pos. bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to transition metal quaternary ammonium thiazolyl hydrazone complex preparation, crystal structure transition metal quaternary ammonium thiazolyl hydrazone complex, antimicrobial activity transition metal quaternary ammonium thiazolyl hydrazone complex, antitumor activity transition metal quaternary ammonium thiazolyl hydrazone complex and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stevanovic, Nevena et al. published their research in JBIC, Journal of Biological Inorganic Chemistry in 2021 |CAS: 24295-03-2

The Article related to quinolinylmethylene hydrazinylpyridinium zinc thiocyanide complex preparation crystal mol structure, thiazolylethylidene hydrazinylethylaminium bismuth complex preparation crystal mol structure antimicrobial, cytotoxic dna complexation metal hydrazone girard t p reagent, antimicrobial activity, cytotoxic activity, dna-binding experiments and other aspects.Name: 2-Acetylthiazole

On December 31, 2021, Stevanovic, Nevena; Mazzeo, Paolo Pio; Bacchi, Alessia; Matic, Ivana Z.; Djordjic Crnogorac, Marija; Stanojkovic, Tatjana; Vujcic, Miroslava; Novakovic, Irena; Radanovic, Dusanka; Sumar-Ristovic, Maja; Sladic, Dusan; Cobeljic, Bofzidar; Andjelkovic, Katarina published an article.Name: 2-Acetylthiazole The title of the article was Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents. And the article contained the following:

In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4]x1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to quinolinylmethylene hydrazinylpyridinium zinc thiocyanide complex preparation crystal mol structure, thiazolylethylidene hydrazinylethylaminium bismuth complex preparation crystal mol structure antimicrobial, cytotoxic dna complexation metal hydrazone girard t p reagent, antimicrobial activity, cytotoxic activity, dna-binding experiments and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, KaiYue et al. published their research in ChemistrySelect in 2020 |CAS: 24295-03-2

The Article related to iron oxide silica supported toluenesulfonic acid nanoparticle catalyst preparation, dihydrospiro benzodiazepine indole chemoselective regioselective green preparation atom economy, phenylenediamine ketone indole multicomponent domino magnetic nanoparticle catalyst, ketone phenylenediamine indole dmf dimethylacetal multicomponent domino magnetic nanocatalyst and other aspects.Formula: C5H5NOS

On November 2, 2020, Zhang, KaiYue; Li, Jing; Wang, KaiXuan; An, Xiaoying; Wang, LanZhi published an article.Formula: C5H5NOS The title of the article was Atom-economical Approaches to 1,5-Benzodiazepines Containing Indole Ring via Fe3O4@SiO2-PTSA-catalyzed Multi-component Domino Reactions. And the article contained the following:

Four novel atom-economical approaches for synthesis of 1,5-dihydrospiro[benzo[b][1,4]diazepine-2,3′-indole] compounds, e.g., I via three-component or four-component domino reactions was developed in presence of a catalytic amount of magnetic nanoparticles (Fe3O4@SiO2-PTSA) in ethanol, which provided an efficient one-pot synthesis of 1,5-benzodiazepines with multi-ring system and functional groups containing indole, aryl, ester, acyl and alkyl groups in excellent yields. In a one-pot operation, two new nitrogen heterocycle (indole and diazepine) rings and four new chem. bonds (one C-C, two C-N and one C=C) were constructed by series of domino reactions. Furthermore, plausible catalytic synthesis reaction mechanisms had been proposed. The advantages of these methods were green reaction process, recyclable magnetic catalyst, mild reaction conditions, short reaction time and high yields of products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to iron oxide silica supported toluenesulfonic acid nanoparticle catalyst preparation, dihydrospiro benzodiazepine indole chemoselective regioselective green preparation atom economy, phenylenediamine ketone indole multicomponent domino magnetic nanoparticle catalyst, ketone phenylenediamine indole dmf dimethylacetal multicomponent domino magnetic nanocatalyst and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Downstream synthetic route of 24295-03-2

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

New learning discoveries about 24295-03-2

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the appropriate ketone (A, 1 equiv) in chloroform, bromine (1 equiv) in chloroform was added dropwise at 0 C. The mixture was stirred at room temperature for 2 h and was washed with H2O (3 50 ml) and saturated Na2S2O3 solution (2 x 50 ml). The organic phase was dried over Na2SO4, filtered andthe solvent was removed in vacuum. The crude alpha-bromoketone (B) was recrystallized from petrolether.48

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vogt, Dominik; Weber, Julia; Ihlefeld, Katja; Brueggerhoff, Astrid; Proschak, Ewgenij; Stark, Holger; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5354 – 5367;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Downstream synthetic route of 24295-03-2

The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 2-(2-Thiazolyl)-1,8-naphthyridine 2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160-165 C., 24295-03-2

The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASF Aktiengesellschaft; US5723413; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

New learning discoveries about 24295-03-2

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.

In a 50 ml round bottom flask, 8 ml of anhydrous diethyl ether and 0.311 ml (2.2 mmol) of diisopropylamine were added and the solution was cooled to -60C.Then, 2.5 N n-hexane solution of BuLi (2.2 mmol) was added dropwise to the upper reaction system, and the reaction system was warmed to 0 C. and stirred for 15 minutes. Then, sclareolide(500 mg, 2.0 mmol) was added dropwise thereto at -60 C. Ether solution,The reaction mixture was stirred for a further 40 min and then a solution of 2-acetylthiazole (254.3 mg, 2.0 mmol) in diethyl ether was added dropwise to the upper reaction system. The reaction system is stirred at this temperature for 50 min and quenched with water.The organic layer was separated, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give CYL-2-QX-3A in a yield of 60.0%.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan China National Tobacco Industry Co., Ltd.; Chongqing China National Tobacco Industry Co., Ltd.; Tao Feiyan; Yang Wenmin; Feng Guanglin; Dai Ya; Li Chaorong; Ding Wei; Wang Yao; Zhou Sheng; Zhou Zhigang; Qiu Guangming; Liu Rucan; Zhang Ting; (11 pag.)CN105061418; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica