Category: 24295-03-2

On June 30, 2022, Rajeswari, Kannuri; Manturthi, Shireesha; Sirisha, Kalam; Velidandi, Amar nath published an article.Safety of 2-Acetylthiazole The title of the article was Anchoring and Hydrophobic Nature of Coumarin in Newer Coumarin Based Chalcones: Synthesis, In Silico, and In Vitro Cell Viability Studies. And the article contained the following:

Coumarin is active pharmacophore; to enhance the activity of chalcone we inserted coumarin along with other cyclic groups. Fewer pyrazolone aldehydes produced using Wills Maeyer Haack reaction by grinding method. In alc. sodium hydroxide, cyclic ketones react with aldehydes to produce title compounds To treat the ill cell a drug must be with a linker, anchoring group, and hydrophobic group. Herein, the enone group acts as a linker, the rings on both sides are connected, one side ring acts as the anchoring group, and the other side ring acts as the hydrophobic group; anchoring, hydrophobic dual roles played by coumarin ring. In this series, In silico studies results have shown that many compounds of this series potent for anti-cancer activity along with other biol. activities, the In vitro cell viability studies of the series shows that, chalcone (I), (VIII), and (IV) are having IC50 values 2.96, 2.97, and 2.82 μM against call 27 (or) oral cancer cell line. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Safety of 2-Acetylthiazole

The Article related to oral cancer coumarin chalcone cell viability hydrophobic, Placeholder for records without volume info and other aspects.Safety of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2022, Li, Juan; Xu, Yuxia; Du, Wenbin; Jin, Linxi; Ren, Peifang; Ren, Fang; Xie, Jian Chun published an article.Name: 2-Acetylthiazole The title of the article was Comparative analysis of aroma compounds in Chinese traditional dry-rendered fat by HS/GC-IMS, SPME/GC-MS, and SPME/GC-O. And the article contained the following:

Aroma compositions of Chinese traditional dry-rendered s.c. chicken, pork, beef, and sheep fats were analyzed by HS/GC-IMS, SPME/GC-MS, and SPME/GC-O. HS/GC-IMS and SPME/GC-MS identified 53 and 86 volatile compounds, resp. SPME/GC-O anal. identified 35 odor-active compounds The identifications included fatty aldehydes, ketones, alcs., acids, and esters from lipid degradation and compounds from the Maillard reaction (e.g., trimethylpyrazine) or other sources (e.g., p-cresol from animal feeds). PCA anal. showed all three approaches could discriminate aroma compositions of the four fats. PCA loading plot suggested the aroma compounds related to each of the four fats and PLS-DA model anal. screened the marker compounds differentiating aroma of the four fats. Notably, SPME/GC-O approach behaved the best in differing aromas of the four fats by PCA. The HS/GC-IMS anal. was biased for the chicken fat and pork fat, and the SPME/GC-MS anal. was biased towards the beef fat and sheep fat in differing the aroma compositions by PCA. PLS-DA model anal. showed that for the SPME/GC-O anal., the marker compounds (VIP scores >1) discriminating aromas of the four fats were hexanal, (E,E)-2,4-decadienal, 2-butanone, 4,5-epoxy-2(E)-decenal, γ-octalactone, γ-undecalactone, heptanal, octanal, 4-ethyloctanoic acid, etc. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to aroma traditional dry rendered fat china, Placeholder for records without volume info and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2020, Kullananant, Natnicha; Chaiseri, Siree; Lorjaroenphon, Yaowapa published an article.Synthetic Route of 24295-03-2 The title of the article was The superiority of ultrapasteurization over conventional heat treatments regarding Riceberry beverage aroma. And the article contained the following:

The novel discovery of p-hydroxyphenylbutan-2-one (berry note) in Riceberry aroma was characterized by gas chromatog.-olfactometry and gas chromatog.-time-of-flight mass spectrometry. Furthermore, ultrapasteurization (UP), high-temperature short-time pasteurization, and ultrahigh-temperature (UHT) sterilization effects on rice beverage aroma were analyzed using Riceberry as a sample. Riceberry’s key odorants also remained the primary aromatic contributors in beverage models. Although descriptive sensory anal. showed a slightly lower musty note intensity in HTST beverages compared to the UP sample, their flavor dilution chromatograms were similar. Cluster anal. and R-index ranking test further confirmed aroma similarities during storage. Stored samples sterilized via UHT experienced certain potential off-odors, including acetic acid, propanoic acid, and indole, as opposed to the other beverages. UP was therefore superior to HTST and UHT by extending beverage shelf life without any undesirable odors. Practical Application : Ultrapasteurization (UP) retains Riceberry aroma characteristic in beverages and requires minimal modifications beyond conventional pasteurization. UP beverages also surpass those of high-temperature short-time and ultrahigh-temperature by extending shelf life with no noticeable off-odors. In addition, the discovery of p-hydroxyphenylbutan-2-one and the other aroma-active compounds of Riceberry aroma should prove valuable for flavor creation, rice breeding, and rice quality standards The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to riceberry beverage odor phydroxyphenylbutan2one processing storage, p-hydroxyphenylbutan-2-one (raspberry ketone), riceberry, aroma, flavor, ultrapasteurization, Food and Feed Chemistry: Beverages and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 15, 2022, Ma, Yue; Beno, Noelle; Tang, Ke; Li, Yuanyi; Simon, Marie; Xu, Yan; Thomas-Danguin, Thierry published an article.SDS of cas: 24295-03-2 The title of the article was Assessing the contribution of odor-active compounds in icewine considering odor mixture-induced interactions through gas chromatography-olfactometry and Olfactoscan. And the article contained the following:

The sensory impact of odor-active compounds on icewine aroma could be influenced by perceptual interactions with other odor-active compounds The aim of this study was to establish an approach to evaluate the contribution of odor-active compounds found in icewine considering mixture-induced perceptual interactions. By comparing the impact of key odorants detected in icewine following a gas chromatog.-olfactometry approach with an Olfactoscan-based methodol. using a background odor of icewine, 69 odor zones were detected, and their related compounds were further identified. The results revealed that icewine background odor could exert odor masking or enhancement on key odorants when they are considered in the complex wine aroma buffer. Several compounds can induce qual. changes in the overall wine aroma. This study underlined the efficiency of Olfactoscan-like approaches to screen for the real impact of key odorants and to pinpoint specific compounds that could be highly influential once embedded in the aroma buffer. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to odor compound icewine olfactometry olfactoscan, aroma buffer, background odor, key odorants, olfactometer, perceptual interactions, Food and Feed Chemistry: Beverages and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chen, Zhipeng; Tang, Haiqing; Ou, Changrong; Xie, Cheng; Cao, Jinxuan; Zhang, Xin published an article in 2021, the title of the article was A comparative study of volatile flavor components in four types of zaoyu using comprehensive two-dimensional gas chromatography in combination with time-of-flight mass spectrometry.Category: thiazole And the article contains the following content:

Volatiles of four zaoyu (Chinese traditional fermented fish) products prepared from different species of marine fish were analyzed by headspace solid-phase micro-extraction (HS-SPME) and comprehensive two-dimensional gas chromatog. in combination with time-of-flight mass spectrometry (GC × GC/TOFMS). First, a 50/30Μ m DVB/CAR/PDMS was used and the influence of several parameters on the efficiency of HS-SPME such as extraction temperature, time, salting-out effect, and stirring were optimized, odor activity values (OAVs) of volatile compounds were computed based on the threshold values of aroma constituents; the characteristic volatiles and their odor characteristics of the four zaoyu were investigated. The results demonstrated that the most effective extraction of the analytes was obtained with a 40 min extraction at 50°C with the addition of 20% NaCl and stirring at 300 r/min. Under these conditions, a total of 288 volatile components were tentatively identified based on mass spectra and comparison of linear retention indexes in the four zaoyu products. Authenticated compounds included aldehydes, esters, alcs., ketones, furans, lactones, nitrogen compounds, sulfur compounds, terpenes, phenols, etc. Among the identified types of volatile compounds, the number of esters is the largest, whereas the content of aldehydes is the highest. The results of OAVs comparisons proved that both aldehydes and esters provided the most significant contribution to the aromas of zaoyu, and each zaoyu product had its own unique active flavor components. Moreover, the OAVs of active flavor compounds common to the four examined zaoyu varied significantly. Our results substantiated that GC × GC/TOFMS could provide a robust tech. means to understand the flavor characteristics of zaoyu and allow us to better evaluate and improve the flavor quality of the products with complex food matrix like zaoyu. The method present in this research is suitable to characterize the volatile constituents of aquatic products, and could also be used for component characterization of similar complex samples such as fermented fish and foods. Understanding the key aroma compounds of fermented fish and its formation mechanism could provide a guide of process optimization and flavor regulation, contributing to further studies related to volatile compounds in the field of food flavor anal. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to volatile flavor component zaoyu product gas chromatog, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2021, Cho, Su-Hyeon; Kim, Song Rae; Jeong, Myeong Seon; Choi, Miri; Park, SeonJu; Kim, Kil-Nam published an article.Reference of 2-Acetylthiazole The title of the article was Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells. And the article contained the following:

To demonstrate the anti-inflammatory activity of Brassica napus L. hydrosols (BNH) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Composition anal. of BNH was conducted via gas chromatog.-mass spectrometry after BNH were extracted The nitric oxide (NO) production was measured using the Griess assay. Prostaglandin E2 (PGE2) production was evaluated with ELISA. The effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated using Western blot anal. Furthermore, phosphorylation of nuclear factor-kappa B (NF-κB) and nuclear translocation of NF-κB p65 were evaluated with Western blot anal. and immunofluorescence staining, resp. Compared with LPS-stimulated cells, BNH markedly decreased the generation of NO and PGE2 in LPS-stimulated RAW 264.7 cells (P<0.01 or P<0.05). Moreover, BNH inhibited protein levels of iNOS and COX-2 (P<0.01). Phosphorylation of NF-κB and nuclear translocation of NF-κB p65 was significantly inhibited by BNH (P<0.01 or P<0.05). The anti-inflammatory activities of BNH were mediated via blockage of the NF-κB signaling pathways in LPS-stimulated RAW 264.7 cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to brassica napus hydrosols inflammation lipopolysaccharide, brassica napus l., raw 264.7 cells, hydrosols, inflammation, lipopolysaccharide, Placeholder for records without volume info and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lin, Wei-Liang; Lin, Chung-Yin; Tai, Dar-Fu published an article in 2021, the title of the article was Preparation of a Molecularly Imprinted Film on Quartz Crystal Microbalance Chip for Determination of Furanic Compounds.Computed Properties of 24295-03-2 And the article contains the following content:

The structural preferences of furanic compounds were studied using a combination of a molecularly imprinted film (MIF) on a piezoelec.-quartz chip. The furanic compounds and their derivatives were used as the templates. Owing to their similar heterocyclic structures, it is difficult to verify the structural differences between the templates. Therefore, a new cross-linker (Methacr-l-Cys-NHBn)2, was employed to generate a platform on a quartz crystal microbalance (QCM) chip. The cross-linker self-assembled to link the surface of the chip to copolymerize with other functional monomers. A layered film with chiral hydrophobicity and rigidity was thus fabricated. Subsequently, Acr-l-Ser-NHBn was utilized as a chiral monomer to construct MIF on a QCM chip. Forcomparison, we synthesized a more hydrophobic monomer, Methacr-l-Ser-NHBn, to enhance the binding ability of the MIF. The QCM flow injection system was handled in an organic solvent system. The proportion of the monomers was adjusted to optimize the recognition ability of these films. As the binding ability of the MIF toward model templates and structurally-related furanic compounds was improved, a MIF derived from 2-furaldehyde (FUL) achieved a lower detection limit (10 ng/mL). The binding properties of MIFs prepared against furanic compounds exhibited strong similarities to the binding properties of other compounds with heterocyclic ring structures. For example, 2-furaldehyde is very similar to 2-formylthiazole, 2-acetylfuran is similar to 2-acetylthiazole, and 2-furfuryl alc. is similar to imidazole-2-methanol. Such recognition ability can help distinguish between the structural counterparts of other small heterocyclic compounds The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to quartz crystal chip molecularly imprinted film furanic compound determination, Organic Analytical Chemistry: Determinations and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Hou, Lixia; Chen, Liyan; Song, Pinqing; Zhang, Yujin; Wang, Xuede published an article.Name: 2-Acetylthiazole The title of the article was Comparative assessment of the effect of pretreatment with microwave and roast heating on the quality of black sesame pastes. And the article contained the following:

Heating is a key procedure in producing sesame paste. The effects of microwave heating and conventional roasting on the physicochem. features, protein profiles, and volatile compounds of black sesame pastes made of black sesame seeds from Burma and China were evaluated in this study. All heating treatments decreased the moisture contents of black sesame pastes, and roasting yielded lower moisture levels, although with similar chroma (p < 0.05). The samples subjected to microwave heating had remarkably lower peroxide values than those heated with roasting (p < 0.05). Chinese microwave-heated samples had a higher nitrogen solubility index than roasting (p < 0.05). Both microwave and roasting increased the contents of the volatiles notably. SDS-PAGE showed that the intensity of the 2-15 kDa band decreased markedly after heating and nearly diminished for roasting samples, suggesting that roasting was more remarkable for the promotion to the protein aggregation. The results indicated that the quality traits of black sesame paste not only depend on the heating methods, but also the heating power/temperature and duration, and the source of the materials. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to microwave roast heating black sesame paste quality pretreatment effect, black sesame, microwave heating, physicochemical properties, roasting, volatile compounds, Placeholder for records without volume info and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Al-Hamashi, Ayad A.; Koranne, Radhika; Dlamini, Samkeliso; Alqahtani, Abdulateef; Karaj, Endri; Rashid, Maisha S.; Knoff, Joseph R.; Dunworth, Matthew; Pflum, Mary Kay H.; Casero, Robert A. Jr; Perera, Lalith; Taylor, William R.; Tillekeratne, L. M. Viranga published an article.COA of Formula: C5H5NOS The title of the article was A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. And the article contained the following:

Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clin. use due to poor selectivity, toxic side effects and multiple drug resistance, warranting the development of new anticancer drugs of different mechanisms of action. Here we describe the design, synthesis and initial biol. evaluation of a new class of antimitotic agents that modulate tubulin polymerization Structurally, these compounds are chalcone mimics containing a 1-(1H-imidazol-2-yl)ethan-1-one moiety, which was initially introduced to act as a metal-binding group and inhibit histone deacetylase enzymes. Although several analogs selectively inhibited purified HDAC8 with IC50 values in low micromolar range, tissue culture studies suggest that HDAC inhibition is not a major mechanism responsible for cytotoxicity. The compounds demonstrated cell growth inhibition with GI50 values of upper nanomolar to low micromolar potency with significant selectively for cancer over normal cells. Interestingly, several compounds arrested HeLaM cells in mitosis and seem to target tubulin to cause mitotic arrest. For example, when combined with inhibitors of Aurora B kinase, they led to dramatic disassembly of the mitotic spindle. In-vitro tubulin polymn studies showed that the compounds reduced the rate of polymn of microtubules during the elongation phase and lowered the amt of polymd tubulin during the plateau phase. Finally, in silico docking studies identified binding of (E)-2-(4-(3-(1H-Imidazol-2-yl)-3-oxoprop-1-en-1-yl)phenyl)-N-(4-fluorophenyl)acetamide to the colchicine site with similar affinity as the test compound D64131. These compounds represent a new antimitotic pharmacophore with limited HDAC inhibitory activity. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to chalcone mimic antitumor antimitotic tubulin disruption microtubule dynamic, anticancer agents, antimitotic agents, chalcones, mitotic arrest, mitotic spindle, Placeholder for records without volume info and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 30, 2022, Li, Jing; Yang, Youyou; Tang, Chaohua; Yue, Shengnan; Zhao, Qingyu; Li, Fadi; Zhang, Junmin published an article.Synthetic Route of 24295-03-2 The title of the article was Changes in lipids and aroma compounds in intramuscular fat from Hu sheep. And the article contained the following:

I.m. fat (IMF) content is associated with lamb flavor and largely varies between individuals of the same breed. However, studies investigating the effects of IMF variations on lipid profiles and aroma compounds are limited. Here, we performed lipidomic and volatilomic profiling of high-IMF and low-IMF Hu lambs. Triglycerides and diglycerides in the high-IMF group were significantly higher than those in the low-IMF group (p < 0.05). Seventy-nine of 842 lipids identified were significantly different between the groups under pos. and neg. ion modes (variable importance in projection > 1, p < 0.05). Volatilomic analyses revealed that the aroma profiles also differed between the groups. Fifteen aroma compounds, mainly originating from lipid oxidation, could be responsible for this difference. Thus, our findings provide a comprehensive understanding of the increases in IMF content that drive consumers′ satisfaction and also provide a basis for underpinning breeding value for IMF. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to lipid aroma compound intramuscular fat hu sheep, intramuscular fat, lipid profile, lipidomics, odorant, partial least squares regression, volatilomics, Placeholder for records without volume info and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica