Category: 24295-03-2

Chai, Li-Juan; Fang, Guan-Yu; Xu, Peng-Xiang; Zhang, Xiao-Juan; Lu, Zhen-Ming; Zhang, Su-Yi; Wang, Song-Tao; Shen, Cai-Hong; Shi, Jin-Song; Xu, Zheng-Hong published an article in 2021, the title of the article was Novisyntrophococcus fermenticellae gen. nov., sp. nov., isolated from an anaerobic fermentation cellar of Chinese strong-flavour baijiu.Category: thiazole And the article contains the following content:

A Gram-stain-neg., coccus-shaped, obligately anaerobic, non-motile and non-spore-forming bacterium, designated strain JN500902T, was isolated from the mud in a fermentation cellar used continuously over 30 years for Chinese strong-flavor baijiu production Colonies were white, circular, convex and smooth-edged. Growth was observed at 20-40 °C (optimum, 37 °C), at pH 5.0-10 (optimum, pH 7.5), with 0-2% (w/v) NaCl and with 0-4% (volume/volume) ethanol. The Biolog assay demonstrated pos. reactions of strain JN500902T in the metabolism of l-fucose and pyruvate. The predominant cellular fatty acids (>10%) consisted of C16:0 and C14:0. The major end metabolites of strain JN500902T were acetic acid and ethanol when incubated anaerobically in liquid reinforced clostridial medium. Acetate was the major organic acid end product. The complete genome size of strain JN500902T was 3420321 bp with 3327 identified genes. The G + C content was 43.5 mol%. Phylogenetic anal. based on 16S rRNA gene sequences affiliated strain JN500902T with the family Lachnospiraceae, having low sequence similarity (92.8%) to the nearest type strain, Syntrophococcus sucromutans DSM 3224T and forming a clearly distinct branch. Core genome phylogenetic anal. of the isolate and 134 strains belonging to the family Lachnospiraceae also revealed that strain JN500902T was well-separated from other genera of this family as a monophyletic clade. The average nucleotide identity and amino acid identity values between strain JN500902T and 134 Lachnospiraceae strains were less than 74 and 65%, resp. Considering its polyphasic characteristics, strain JN500902T represents a novel genus and species within the family Lachnospiraceae, for which the name Novisyntrophococcus fermenticellae gen. nov., sp. nov. is proposed. The type strain is JN500902T (= CICC 24502T = JCM 33939T). The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to sequence novisyntrophococcus baijiu anaerobic fermentation cellar, lachnospiraceae, baijiu (chinese liquor), pit mud, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aslam, Sana; Xi, Yun; Ahmad, Matloob; Mansha, Asim; Farooq, Tahir; Zheng, Zongheng; Saddique, Furqan Ahmad; Wang, Fang; Fu, Liwu published an article in 2020, the title of the article was Anticancer activity of structural hybrids of various 5/6-memberedheterocycles with pyrazolobenzothiazine 5,5-dioxide.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

Thiophene, furan, coumarin and pyrazolobenzothiazine are well familiar for their biol. activities. In this research, pyrazolobenzothiazine ring system is hybridized with various S, N & O-containing heterocycles and the resulting compounds were screened for their anticancer activity against six different cancer cell lines i.e., KB (human oral carcinoma cells), MCF-7(human breast carcinoma cells), A549 (human alveolar adenocarcinoma cells), Hep-G2 (liver carcinoma cells), SGC-7901(human gastric carcinoma cells) and S1 (human colon carcinoma cells) using MTT assay. Most of the compounds exhibited good activity against KB, S1 and A549 cancer cell lines. 5k and 5p appeared as potent inhibitors of KB cell line with IC50 values 2.78 and 4.39 μM resp., 5q was a potent inhibitor of MCF-7 (IC50 value = 13.64 μM) and 5j an excellent inhibitor of A549 cell line having IC50value of 1.03 μM. 5p and 5q were inhibitors of S1 cell line (IC50 values of 8.29 μM and 7.69 μM resp.), whereas, 5o and 5q as inhibitors of Hep-G2 cell line were discovered. A number of compounds show activity exceeding that of 5-fluoruracil in different cell assays. The most potently active compounds, 5j, 5p and 5q, exhibited selectivity in targeting cancerous cells as compared to normal human PBM cells while, 5k and 5o displayed significant toxicity in normal cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to human gastric liver colon carcinoma memberedheterocycle pyrazolobenzothiazine dioxide anticancer, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 5, 2021, El-Nahass, Marwa N. published an article.Electric Literature of 24295-03-2 The title of the article was D-π-A chalcone analogue as metal ions selective turn-on-off-on fluorescent chemosensor with cellular imaging and corrosion protection. And the article contained the following:

Novel naked eye optical chemosensor containing thiazole ring, namely; (2E,4E)-5-(4-(dimethylylamino)phenyl)-1-(thiazol-2-yl)penta-2,4-dien-1-one, DMAPTP was developed. The solvatochromic response was explored in different solvents of various polarities. The dipole moments in the ground (μg) and excited (μe) states were determined The large excited state dipole moment demonstrates the excited state′s stability in polar solvents. In an ethanolic solution, the sensing response and selectivity of the investigated chemosensor to various metal ions such as Na+, K+, Ca2+, Ba2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Al3+, Hg2+, and Pb2+ were evaluated. The spectral changes suggest that DMAPTP is strongly complexed with the metal ions used. The ground and excited state binding constants, as well as the quenching constants, have been determined The mechanism of fluorescence quenching was identified as static quenching due to the formation of a non-fluorescent ground state complex using the Stern-Volmer plot. DMAPTP can also be used as a powerful chemosensor, identifying all of the metal ions studied with high sensitivity and selectivity for Fe3+ ions. DMAPTP can serve as a Turn-on-off-on chemosensor, as well as a metallochromic predictor in complexometric titration This is indicated by the ability of EDTA to decompose the formed complex with the formation of the stable metal-EDTA complex, which leads to fluorescence recovery. The anal. parameters, such as selectivity, sensitivity, and detection limit, were chosen. The fluorescence imaging experiments in living cells demonstrated the biol. chemosensing applications of DMAPTP to Fe3+ ions. Furthermore, weight loss, potentiodynamic polarization, electrochem. impedance spectroscopy, and SEM techniques were used to investigate DMAPTP as a corrosion inhibitor for carbon steel in 1.0 M HCl. The collected data reveal that as DMAPTP concentrations increased, its inhibition performance increased as well. On the basis of strong adsorption of inhibitor mols. on the surface of carbon steel and the formation of large protection films, the inhibition efficiencies were determined The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to chalcone analog metal fluorescent chemosensor cellular imaging corrosion protection, Placeholder for records without volume info and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 3, 2021, Trofymchuk, Serhii; Bugera, Maksym; Klipkov, Anton A.; Ahunovych, Volodymyr; Razhyk, Bohdan; Semenov, Sergey; Boretskyi, Andrii; Tarasenko, Karen; Mykhailiuk, Pavel K. published an article.HPLC of Formula: 24295-03-2 The title of the article was Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4). And the article contained the following:

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).HPLC of Formula: 24295-03-2

The Article related to fluorinated aromatic compound preparation, aryl ketone deoxofluorination sulfur tetrafluoride, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2021, Hu, Yuanyuan; Hu, Chunfang; Pan, Guangxing; Yu, Congwei; Ansari, Mohammad Fawad; Yadav Bheemanaboina, Rammohan R.; Cheng, Yu; Zhou, Chenghe; Zhang, Jiaheng published an article.Formula: C5H5NOS The title of the article was Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. And the article contained the following:

The increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics has led to a growing effort to design and synthesize novel structural candidates of chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids with outstanding bacteriostatic potential. Bioactivity screening showed that hybrid 5i, which was modified with methoxybenzene, exerted a significant inhibitory activity against MRSA (MIC = 0.004 mM), which was 6 times better than the anti-MRSA activity of the reference drug norfloxacin (MIC = 0.025 mM). Compound 5i neither conferred apparent resistance onto MRSA strains even after multiple passages nor triggered evident toxicity to human hepatocyte LO2 cells and normal mammalian cells (RAW 264.7). Mol. docking showed that highly active mol. 5i might bind to DNA gyrase by forming stable hydrogen bonds. In addition, mol. electrostatic potential surfaces were developed to explain the high antibacterial activity of the target compounds Furthermore, preliminary mechanism studies suggested that hybrid 5i could disrupt the bacterial membrane of MRSA and insert itself into MRSA DNA to impede its replication, thus possibly becoming a potential antibacterial repressor against MRSA. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to staphylococcus methicillin resistance antibacterial chalcone macrophage hepatocyte, antibacterial, chalcone, coumarin, dna, mrsa, thiazole, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2021, Berenguer, Cristina; Pereira, Jorge A. M.; Camara, Jose S. published an article.SDS of cas: 24295-03-2 The title of the article was Fingerprinting the volatile profile of traditional tobacco and e-cigarettes: A comparative study. And the article contained the following:

Electronic cigarettes (e-cigarettes) have become popular alternatives to traditional tobacco. Despite this, a comprehensive evaluation of their long-term effects and safety for the consumers and the environment is missing. To contribute to filling this gap, headspace solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS) was employed to establish and compare the volatile fingerprints of traditional tobacco and e-cigarettes. The anal. of traditional tobacco included two popular brands and different parts of the cigarette (solid tobacco, cigarette smoke, cigarette paper and filter). Regarding the e-cigarettes, two e-liquids, with and without nicotine, their main constituents (e-bases) and corresponding vapors, obtained under default vaping (power) conditions, were analyzed. A total of 80 volatile organic compounds (VOCs) were identified in traditional tobacco, of which 14 carbonyl compounds, 9 benzene derivatives, 9 Et esters and 9 hydrocarbons. Slight differences in the volatile profile of cigarette paper and filter between the two brands were also detected, showing that exogenous components of tobacco influence the flavor and harmfulness perceived by the smokers. In turn, 92 VOCs were identified in e-cigarettes, including 31 Et esters, 18 alcs. and 10 hydrocarbons. No VOCs with potentially toxic or harmful effects were identified in the vapor of Do It Yourself (DIY) liquids and Premium samples. Therefore, taking into consideration the volatile compositions obtained for smoking and vaping procedures under normal conditions of operation and using certified e-liquid mixtures, the e-cigarettes analyzed seemed to constitute a valid and less harmful alternative to traditional tobacco for smokers, second-hand smokers and the environment. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to traditional tobacco cigarette volatile profile fingerprinting, Plant Biochemistry: Tobacco and Tobacco Products and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Ruiz-Moyano, Santiago; Hernandez, Alejandro; Galvan, Ana I.; Cordoba, Maria G.; Casquete, Rocio; Serradilla, Manuel J.; Martin, Alberto published an article.COA of Formula: C5H5NOS The title of the article was Selection and application of antifungal VOCs-producing yeasts as biocontrol agents of grey mould in fruits. And the article contained the following:

Rotting caused by gray mold (Botrytis cinerea) is a concerning disease for numerous crops both pre- and postharvest stages. Application of antagonistic yeasts is a promising strategy for controlling gray mold incidence which could mitigate undesirable consequences of using synthetic fungicides. In this work, a screening for detection of yeasts isolated from figs producers of antifungal volatile organic compounds (VOCs) were performed by confrontation in double dishes systems. Eleven out of 34 yeasts confronted reduced B. cinerea growth parameter in vitro. This reduction was correlated (p ≤ 0.050) with the production of 10 volatile compounds: two acids (acetic acid and octanoic acid), 7 esters (Et propionate, n-Pr acetate, Iso-Bu acetate, 2-methylbutyl acetate, furfuryl acetate, phenylmethyl acetate, 2-phenylethyl acetate) and one ketone (Heptan-2-one). In bases on in vitro assay, Hanseniaspora uvarum 793 was applied to in vivo assays with strawberries and cherries. The reduction of incidence of B. cinerea in strawberries at 7°C and 25°C was 54.9 and 72.1% after 6 and 3 days, resp. The reduction of incidence of B. cinerea in cherries at 7°C and 25°C was 48.9 and 45.6% after 5 and 4 days, resp. These results showed that VOCs produced by Hanseniaspora uvarum 793 are effective in the control of incidence of Botrytis cinerea in fruits, being a potential alternative to chem. fungicide. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to antifungal volatile compound yeast gray mold fruit, antifungal volatile compounds, botrytis cinerea, cherry, postharvest, strawberry, Food and Feed Chemistry: Feeds and Animal Foods and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2020, Mariammal, Balasubramanian; Shylaja, Adaikalam; Kumar, Sundaravel Vivek; Rubina, Stephen Raja; Kumar, Raju Ranjith published an article.Electric Literature of 24295-03-2 The title of the article was Thiazole-tethered biaryls as fluorescent chemosensors for the selective detection of Fe3+ ions. And the article contained the following:

3-Amino-5-(thiazol-2-yl)-[1,1′-biaryl]-2,4-dicarbonitriles have been synthesized employing a facile one-pot pseudo four-component domino strategy. All these thiazole-tethered biaryls exhibited blue fluorescence under UV lamp. Based on the high relative quantum yield, three compounds namely, 4a, 4d, and 4i, were chosen to explore the metal interference studies. Against several metal ions, these three thiazole-tethered biphenyl probes were found to be effective fluorescent chemosensors for the selective and sensitive detection of Fe3+ ions with a lower detection limit of 0.18, 0.12, and 0.16μM, resp. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to thiazole tethered biaryls fluorescent chemosensor iron, Inorganic Analytical Chemistry: Determinations and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 4, 2021, Polishchuk, Iuliia; Sklyaruk, Jan; Lebedev, Yury; Rueping, Magnus published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones. And the article contained the following:

Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands I and II were found to catalyze the direct reductive amination of aromatic and aliphatic ketones e.g.,2-Naphthyl Me ketone under mild conditions at 0.5 mol% loading with high selectivity towards primary amines e.g.,1-(naphthalen-2-yl)ethan-1-amine. One of the complexes I was found to be active in both the Leuckart-Wallach (H4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atm., dry solvents, as well as additives and in contrast to previous reports takes place in hexafluoroisopropanol (HFIP) instead of methanol. NH4CO2D or D2 is resulted in a high degree of deuterium incorporation into the primary amine α-position. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to primary amine preparation, ketone reductive amination iridium catalyst, deuteration, iridium catalysis, primary amines, reductive amination, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thomson, Connor J.; Barber, David M.; Dixon, Darren J. published an article in 2020, the title of the article was Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones.Electric Literature of 24295-03-2 And the article contains the following content:

The catalytic enantioselective synthesis of α-fluorinated chiral tertiary alcs. from (hetero)aryl Me ketones is described. The use of a bifunctional iminophosphorane (BIMP) superbase was found to facilitate direct aldol addition by providing the strong Bronsted basicity required for rapid aryl enolate formation. The new synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocycles with high enantioselectivity (up to >99:1 e.r.). Multi-gram scalability was demonstrated along with catalyst recovery and recycling. 1H NMR studies identified a 1400-fold rate enhancement under BIMP catalysis, compared to the prior state-of-the-art catalytic system. The utility of the aldol products was highlighted with the synthesis of various enantioenriched building blocks and heterocycles, including 1,3-aminoalc., 1,3-diol, oxetane, and isoxazoline derivatives The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to enantioselective catalyst aldol aryl ketone alpha fluorinated, aldol, aryl enolates, enantioselective catalysis, organocatalysis, superbase, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica