Category: 24851-69-2

Synthetic Route of 24851-69-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 24851-69-2, Name is 2-Methylbenzo[d]thiazole-5-carboxylic acid, molecular formula is C9H7NO2S. In a Patent，once mentioned of 24851-69-2

A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom,???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 24851-69-2 is helpful to your research., Synthetic Route of 24851-69-2

Reference：
Thiazole | C3H3595NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 24851-69-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 24851-69-2, Name is 2-Methylbenzo[d]thiazole-5-carboxylic acid, molecular formula is C9H7NO2S. In a Article，once mentioned of 24851-69-2

This Letter details our efforts to discover structurally unique M4 PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of the 2,3-dimethyl-2H-indazole-5-carboxamide and 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxamide cores, we investigated a plethora of core replacements. This exercise identified a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide core that provided improved M4 PAM activity and CNS penetration.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 24851-69-2 is helpful to your research., Synthetic Route of 24851-69-2

Reference：
Thiazole | C3H3585NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 24851-69-2. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 24851-69-2, Name is 2-Methylbenzo[d]thiazole-5-carboxylic acid

Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles

The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6month period. There is thus an urgent need for the discovery and development of novel, more active, and less toxic anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl) isoxazole-3-carboxamide derivatives, which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H37Rv. The most potent compounds 7j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MICvalues of 1.4 and 1.9 muM, respectively. Impressively, all active compounds were nontoxic toward Vero cells (IC50 > 128 muM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as anti-TB drugs and as possible antimalaria drugs. 2009 American Chemical Society.

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Reference：
Thiazole | C3H3589NS – PubChem,
Thiazole | chemical compound | Britannica