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Cesium carbonate-promoted synthesis of aryl methyl sulfides using: S -methylisothiourea sulfate under transition-metal-free conditions

In the presence of cesium carbonate, an efficient synthesis of aryl methyl sulfides by the reactions of aryl halides with commercially available S-methylisothiourea sulfate is developed. This odourless and highly crystalline solid can be used as the substitute for malodorous methanethiol. The gram-scale reaction also proceeds smoothly without the use of column chromatography separation. Similarly, 2-(dimethylamino)ethylthio and cyclopropylmethylthio groups can be easily introduced into the aromatic rings from the corresponding S-[2-(dimethylamino)ethyl]isothiourea dihydrochloride and S-cyclopropylmethylisothiourea hydrobromide. The possible reaction mechanism is proposed. It is believed that this route to aryl alkyl sulfides is well competitive with currently known methods due to its wide substrate scope, excellent yields, easy operation and transition-metal-free conditions.

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Reference:
Thiazole | C3H2701NS – PubChem,
Thiazole | chemical compound | Britannica

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A N – heteroaryl carbazole compound of preparation method (by machine translation)

The invention relates to a N – hetero aryl carbazole compound of preparation method: to carbazole compound and heteroaryl halide as raw materials, Cu (I) salt as catalyst, 1 – methyl imidazole-ligand, in the presence of alkaline material uncle butanol lithium protection of nitrogen conditions for 110 – 130 C in an organic solvent in the reaction 1.2 hours -5.0 days, to be after the reaction, the reaction mixture separation and purification, formula (I), formula (II) or formula (III) shown in the carbazole compound N – heteroaryl; the hetero aryl halide is heteroaryl bromide or heteroaryl iodides. The invention cheap price of raw materials, the reaction process and the operation is simple, a yield as high as 90% or more and is suitable for large-scale preparation and industrialization, it has broad application prospects. (by machine translation)

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Reference:
Thiazole | C3H2669NS – PubChem,
Thiazole | chemical compound | Britannica

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An efficient copper-catalyzed amination of aryl halides by aqueous ammonia

The copper(I) bromide/1-(5,6,7,8-tetrahydroquinolin-8-yl)-2-methylpropan-l- one (CuBr-LS) combination catalyzed the cross-coupling reactions between aryl or heteroaryl halides and aqueous ammonia with high yields to produce primary aromatic or heteroaromatic amines at room temperature or under mild conditions.

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Reference:
Thiazole | C3H2678NS – PubChem,
Thiazole | chemical compound | Britannica

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NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles

The pair NaBH4-TMEDA as hydride source and a palladium catalyst in THF prove to be an efficient system for the hydrodehalogenation of halogenated heterocycles with one or more heteroatoms. In general, Pd(OAc) 2-PPh3 rapidly hydrodehalogenates reactive halo-heterocycles such as bromo-pyridines, -quinolines, -thiophenes, -indoles, -imidazoles, etc., at room temperature in very good yields, whereas in most cases PdCl2(dppf) reduces less reactive halides such as chloro-pyridines, -quinolines, -pyrimidines and bromo-indoles, -benzofurans, etc. Moreover, PdCl2(tbpf) shows to be even more active removing the 2- and 5-chlorine from both thiophene and thiazole rings. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene and nitrile substituents. Moreover, with a proper selection of the catalyst it is also possible to obtain a good control in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.

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Reference:
Thiazole | C3H2664NS – PubChem,
Thiazole | chemical compound | Britannica

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2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 2516-40-7, Application In Synthesis of 2-Bromobenzothiazole

A semi-[…] complex and its preparation and use (by machine translation)

The present invention provides a semi-[…] complex and its preparation and application, the semi-[…] complex, characterized in that it has the following structure as shown in: Wherein the representative “·” BH synthesis technique of this invention is simple green, has excellent selectivity and high yield. The invention iridium complex has stable physical and chemical properties and characteristics such as thermal stability, and under the condition of MAO as cocatalyst can be under the normal pressure effectively catalyze norbornene polymerization, polymerization mode is the addition polymerization, the resulting polymer also has relatively high molecular weight. (by machine translation)

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Reference:
Thiazole | C3H2658NS – PubChem,
Thiazole | chemical compound | Britannica

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Sulfonylation of five-membered heterocycles via an SNAr reaction

An efficient, concise, and transition metal-free synthesis of functionalized sulfonylated five-membered heterocyclic compounds via an S NAr reaction has been developed. Using commercially available sodium sulfinates as sulfonylation reagents, various five-membered heterocyclic sulfones were obtained in good yields.

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Reference:
Thiazole | C3H2733NS – PubChem,
Thiazole | chemical compound | Britannica

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2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 2516-40-7, SDS of cas: 2516-40-7

Compounds of the formula STR1 wherein R is thienyl, mono-, di- and trihalothienyl, furyl, 2-benzothiazolyl, pyridyl or chloropyridyl and their pharmaceutically acceptable salts are useful agents for combating fungal infections in animals, including humans.

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Reference£º
Thiazole | C3H2725NS – PubChem,
Thiazole | chemical compound | Britannica

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The invention belongs to the technical field of medicine and relates to novel benzothiazole compounds capable of inhibiting gastric acid secretion and resisting Helicobacter pylori. The compounds effectively bind with the H+K+-ATP enzyme in vivo so as to eventually inhibit gastric acid secretion, and the compounds have good gastric acid inhibiting and anti-gastric ulcer activity. The structural formula (I) of the compounds is described in the specification, and R, m and n in the formula (I) are defined in claim 1.

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Reference£º
Thiazole | C3H2675NS – PubChem,
Thiazole | chemical compound | Britannica

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In an article, published in an article, once mentioned the application of 2516-40-7, Name is 2-Bromobenzothiazole,molecular formula is C7H4BrNS, is a conventional compound. this article was the specific content is as follows.HPLC of Formula: C7H4BrNS

An efficient protocol for the copper-mediated trifluoromethylthiolation of heteroaryl bromides has been achieved using the copper complex (bpy)Cu(SCF3) as trifluoromethylthiolating reagent. This procedure provides a straightforward synthetic method for heteroaryl trifluoromethyl sulfides from readily available, simple starting materials. The reaction demonstrates a broad substrate scope and tolerates a wide array of functional groups, including nitrile, ester, chloro, nitro, or methoxy substituents.

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Reference£º
Thiazole | C3H2734NS – PubChem,
Thiazole | chemical compound | Britannica

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Herein an exogenous oxidant- A nd metal-free electrochemical heteroaryl migration triggered by N radicals to construct new N-C bonds was developed. This methodology features a high atom economy and utilization rate of energy, and it is insensitive to water and air. Moreover, a user-friendly undivided cell was employed. The use of an organic catalyst makes it more efficient, green, and practical.

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Reference£º
Thiazole | C3H2708NS – PubChem,
Thiazole | chemical compound | Britannica