Category: 262444-15-5

262444-15-5, Name is (4-Bromothiazol-5-yl)methanol, molecular formula is C4H4BrNOS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 262444-15-5, Safety of (4-Bromothiazol-5-yl)methanol

Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of (4-Bromothiazol-5-yl)methanol. In my other articles, you can also check out more blogs about 262444-15-5

Reference：
Thiazole | C3H16NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 262444-15-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 262444-15-5, Name is (4-Bromothiazol-5-yl)methanol. In a document type is Article, introducing its new discovery.

5-(Hydroxymethyl)thiazole is a versatile building block for many biologically active compounds. A rapid and efficient four- step synthesis of its stable isotope labeled counterpart with four 13C and four deuterium atoms in 32% total yield is reported. Condensation of [13C 2]-chloro acetic acid with [13C]-thiourea gave [ 13C3]-2,4-thiazolidinedione. Reaction of [ 13C3]-2,4-thiazolidinedione with phosphorus oxybromide and [13C, D]-DMF (Me2N13CDO) produced [ 13C4 D]-2,4-dibromo- thiazole-5-carboxaldehyde. The resultant aldehyde was then reduced by sodium borodeuteride to [ 13C4, D2]-(2,4-dibromo- thiazol-5-yl)-methanol. Catalytic deuteration of [13C4, D2]-(2,4- dibromo-thiazol-5-yl)-methanol by palladium black with deuterium gas at 1 atm pressure and room temperature produced completely de-brominated [ 13C4, D4]-5-(hydro- xymethyl)thiazole. De-bromination of the 2,4-dibromothiazole by the catalysis of palladium black provides a simple and convenient synthetic method for the stable isotope labeled and potentially radioactive isotope labeled thiazole compounds. Copyright

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Reference：
Thiazole | C3H18NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 262444-15-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 262444-15-5, Name is (4-Bromothiazol-5-yl)methanol

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4?, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

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Reference：
Thiazole | C3H12NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.262444-15-5, Name is (4-Bromothiazol-5-yl)methanol, molecular formula is C4H4BrNOS. In a Patent，once mentioned of 262444-15-5, Computed Properties of C4H4BrNOS

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 262444-15-5 is helpful to your research., Computed Properties of C4H4BrNOS

Reference：
Thiazole | C3H14NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 262444-15-5, Name is (4-Bromothiazol-5-yl)methanol,molecular formula is C4H4BrNOS, is a conventional compound. this article was the specific content is as follows.Product Details of 262444-15-5

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.

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Reference£º
Thiazole | C3H15NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 262444-15-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 262444-15-5, Name is (4-Bromothiazol-5-yl)methanol. In a document type is Patent, introducing its new discovery.

4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4′, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

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Reference：
Thiazole | C3H13NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262444-15-5,(4-Bromothiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a pale yellow solution of (4-bromothiazol-5-yl)methanol (870 mg) in DCM (25 mL) was added DMP (2.16 g) at RT. The resulting yellow suspension was stirred at RT under argon for 18 h. EA and aq. sat. NaHCO3 were added to the reaction mixture and stirred for 5 min. Water was added and the mixture was extracted with DCM three times. The combined org. layers were dried over MgSO4, filtrated off and evaporated in vacuo. CC (Biotage, SNAP 50 g cartridge, solvent A: Hept; solvent B: EA; gradient in % B: 10 for 5CV, 10 to 30 over 2CV, 30 for 3CV) afforded 708 mg of yellow solid. 1H-NMR (CDCl3): 10.0 (s, 1H); 9.04 (s, 1H), 262444-15-5

The synthetic route of 262444-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Caroff, Eva; Keller, Marcel; Kimmerlin, Thierry; Meyer, Emmanuel; US2014/371204; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica