Category: 2634-33-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.21 2-(3-(4-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (25) Compound 25 was prepared through 3-(4-methoxyphenyl)propionic acid, obtained a white solid in 94% yield. Mp 110.8-112.1 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 8.0 Hz, 1H), 7.20 (d, J = 8.4 Hz, 2H), 6.86 (d, J = 8.4 Hz, 2H), 3.72 (s, 3H), 3.36 (t, J = 7.6 Hz, 2H), 2.90 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.7, 163.5, 158.1, 141.3, 135.0, 132.9, 129.8, 127.4, 126.6, 125.7, 122.5, 114.2, 55.4, 39.4, 29.2. IR (KBr, cm-1): 1690, 1671. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0836.

2634-33-5, As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of 1,2-benzisothiazol-3-one 1 (151 mg, 1 mmol), inTHF (10 ml), K2CO3 (276 mg, 2 mmol) was added at room temperaturefor 30 min, then t-butyl bromoacetate 10 (195 mg, 1 mmol)was added. After the reaction was stirred at room temperaturefor 3 h, the solvent was removed under vacuum. The residualwas isolated by column chromatography (ethyl acetate/petroleumether, 15:1) to yield 11. The intermediate 11 (265 mg, 1 mmol) indry CH2Cl2 (10 ml) was treated with trifluoroacetic acid (TFA,3.3 ml) for 5 h at room temperature and the solvent was removedunder vacuum. The residue washed with ethyl ether (2 25 ml) toyield the desired product 12 as white solid. A solution of compound 12 (209 mg, 1 mmol) in dry THF(10 ml) was added portion wise to a suspension of carbonyldiimidazole(162 mg, 1 mmol) in THF (5 ml) and the mixture was stirredat room temperature for 20 min and then refluxed for 10 min.A solution of primary amine (1 mmol) in THF (5 ml) was addedand the reaction mixture was stirred at room temperature overnight.A white precipitate formed, which was collected by suctionfiltration.

2634-33-5, The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2416 – 2426;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.,2634-33-5

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.19 2-(3-(2-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (23) Compound 23 was prepared through 3-(2-methoxyphenyl)propionic acid, obtained a white solid in 93% yield. Mp 149.5-150.7 C. 1H NMR (400 MHz, CDCl3) delta 8.00 (d, J = 8.0 Hz, 1H), 7.68 (t, J = 8.0 Hz, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.39 (t, J = 8.0 Hz, 1H), 7.25-7.17 (m, 2H), 6.89 (t, J = 8.0 Hz, 1H), 6.85 (d, J = 8.4 Hz, 1H), 3.82 (s, 3H), 3.47 (t, J = 7.6 Hz, 2H), 3.09 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.9, 163.5, 157.6, 141.4, 135.0, 130.2, 128.6, 128.1, 127.4, 126.5, 125.7, 122.5, 120.8, 111.1, 55.7, 37.5, 24.9. IR (KBr, cm-1): 1689, 1675. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0843.

The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.33 2-(4-(Thiophen-2-yl)butanoyl)benzo[d]isothiazol-3(2H)-one (37) Compound 37 was prepared through 4-(2-thienyl)butyric acid, obtained a white solid in 81% yield. Mp 117.4-118.3 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.33 (dd, J = 4.8, 0.8 Hz, 1H), 6.95 (dd, J = 4.8, 3.6 Hz, 1H), 6.89 (d, J = 2.8 Hz, 1H), 3.16 (t, J = 7.6 Hz, 2H), 2.91 (t, J = 7.6 Hz, 2H), 2.04-1.96 (m, 2H); 13C NMR (101 MHz, DMSO-d6) delta 173.1, 163.5, 144.5, 141.4, 135.0, 127.4, 126.5, 125.7, 125.1, 124.1, 122.5, 36.5, 28.9, 26.2. IR (KBr, cm-1): 1699, 1687. HRMS-ESI (m/z) calcd for C15H13NO3S2 [M+H+] 304.0466, found 304.0478., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.8 2-(2-(2-Fluorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (12) Compound 12 was prepared through 2-fluorophenylacetic acid, obtained a white solid in 75% yield. Mp 154.3-155.5 C. 1H NMR (400 MHz, DMSO-d6) delta 7.99 (d, J = 8.0 Hz, 2H), 7.82 (td, J = 8.0, 1.2 Hz, 1H), 7.50 (t, J = 8.0 Hz, 1H), 7.42-7.34 (m, 2H), 7.23-7.17 (m, 2H), 4.52 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.4, 163.8, 161.3 (d, J = 243 Hz), 141.5, 135.2, 132.7 (d, J = 4.0 Hz), 129.8 (d, J = 8.0 Hz), 127.5, 126.7, 125.5, 124.8 (d, J = 3.0 Hz), 122.7, 121.6 (d, J = 16 Hz), 115.5 (d, J = 21 Hz), 37.5. IR (KBr, cm-1): 1705, 1690. HRMS-ESI (m/z) calcd for C15H10FNO2S [M+H+] 288.0494, found 288.0495., 2634-33-5

As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.11 2-(2-(2-Chlorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (15) Compound 15 was prepared through 2-chlorophenylacetic acid, obtained a white solid in 79% yield. Mp 171.3-172.5 C. 1H NMR (400 MHz, DMSO-d6) delta 8.00 (dd, J = 8.0, 3.6 Hz, 2H), 7.83 (t, J = 8.0 Hz, 1H), 7.53-7.45 (m, 3H), 7.38-7.34 (m, 2H), 4.62 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.3, 163.8, 141.5, 135.2, 134.3, 132.79, 132.77, 129.6, 129.5, 127.7, 127.6, 126.7, 125.5, 122.7, 41.8. IR (KBr, cm-1): 1700, 1685. HRMS-ESI (m/z) calcd for C15H10ClNO2S [M+H+] 304.0199, found 304.0197., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica