Category: 278183-10-1

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The invention relates to the field of pharmaceutical chemistry, in particular to a novel benzamide compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of Methyl 4-amino-5-thiazolecarboxylate. In my other articles, you can also check out more blogs about 278183-10-1

Reference：
Thiazole | C3H8463NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 278183-10-1, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 278183-10-1, C5H6N2O2S. A document type is Article, introducing its new discovery.

6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethyl)-2-benzyl(phenethyl, biphenyl-4′-yl, 6′-methylnaphthalen-2′-yl, t-butyl and cyclohexyl)imidazo<1,2-b>pyridazines have been prepared and examined for activity in the central nervous system.Of these, 2-benzyl-3-methoxy-6-(3′-methoxybenzylamino)imidazo<1,2-b>pyridazine (IC50 88 nM) bound most strongly to rat brain membrane.In general, the order of activity for groups at the 2-position was Ph>PhCH2>PhCH2CH2>C6H4Ph-p, 6′-methylnaphthalen-2′-yl, c-C6H11 or But.

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Reference：
Thiazole | C3H8472NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 278183-10-1. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 278183-10-1, Name is Methyl 4-amino-5-thiazolecarboxylate. In a document type is Article, introducing its new discovery.

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)imidazo<1,2-b>pyridazines (1) and 3-methoxy-2,6-diphenylimidazo<1,2-b>pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the corresponding imidazo<1,2-b>pyridazin-3(5H-ones with diazoalkanes. 6-Chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine was prepared similarly.

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Reference：
Thiazole | C3H8469NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 278183-10-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 278183-10-1, Name is Methyl 4-amino-5-thiazolecarboxylate

Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

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Reference：
Thiazole | C3H8467NS – PubChem,
Thiazole | chemical compound | Britannica

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Imidazo<1,2-b>pyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo<1,2-b>pyridaz

Syntheses of some 3-(acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo<1,2-b>pyridazines from the 3-unsubstituted analogues are described.The IC50 values (or percentage displacements) are reported and discussed for the displacement of <3H>diazepam from rat brain membrane by each of these compounds.The 3-benzamidomethyl compounds were generally the most active; of these, 3-benzamidomethyl-2-(3′,4′-methylenedioxyphenyl)-6-methylthioimidazo<1,2-b>pyridazine showed oustanding activity with IC50 2 nM.

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Reference：
Thiazole | C3H8464NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 278183-10-1. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 278183-10-1, Name is Methyl 4-amino-5-thiazolecarboxylate. In a document type is Article, introducing its new discovery.

Syntheses are reported for some 3-(benzamido- and fluorobenzamido-methyl)-6-(fluoro, chloro and methylthio)-2-(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl)imidazo<1,2-b>pyridazines from the relevant 3-unsubstituted imidazo<1,2-b>pyridazines and the N-(hydroxymethyl)benzamides.In tests of the ability of these compounds to displace <3H>diazepam from rat brain membrane, 3-(3- or 4-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)-6-methylthioimidazo<1,2-b>pyridazine bound most strongly, with IC 50 2 nM; but in behavioural tests in rats the most active compounds were 6-chloro(and methylthio)-3-(2-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)imidazo<1,2-b>pyridazines which showed a significant anxiolytic activity at 2.5 mg/kg.

Syntheses are reported for some 3-(benzamido- and fluorobenzamido-methyl)-6-(fluoro, chloro and methylthio)-2-(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl)imidazo<1,2-b>pyridazines from the relevant 3-unsubstituted imidazo<1,2-b>pyridazines and the N-(hydroxymethyl)benzamides.In tests of the ability of these compounds to displace <3H>diazepam from rat brain membrane, 3-(3- or 4-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)-6-methylthioimidazo<1,2-b>pyridazine bound most strongly, with IC 50 2 nM; but in behavioural tests in rats the most active compounds were 6-chloro(and methylthio)-3-(2-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)imidazo<1,2-b>pyridazines which showed a significant anxiolytic activity at 2.5 mg/kg.

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Reference£º
Thiazole | C3H8465NS – PubChem,
Thiazole | chemical compound | Britannica