Category: 2786-51-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2786-51-8,5-Chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

2786-51-8, General procedure: 1 mL Xylene was added into the flask charged with 0.25 mmol 4-quinolinonyl triflate, 0.75 mmol benzothiazole, 5 mol% Pd(TFA)2 (4.1 mg), 20 mol% PCy (14 mg), 0.25 mmol K2CO3, 10 mol% CuI (4.7 mg). The mixture was stirred at 140oC under Ar for 12 hours, then cooled down to room temperature, diluted with 20 mL ethyl acetate and washed with 10 mL H2O. The aqueous layer was extracted twice with ethyl acetate (5 mL) and the combined organic phase was dried over Na2SO4. After evaporation of the solvents the residue was purified by flash column chromatography (silica gel, PE/EtOAc) to afford the desired products 3 and 5.

2786-51-8 5-Chlorobenzo[d]thiazole 14388566, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Tao; Tetrahedron Letters; vol. 57; 51; (2016); p. 5837 – 5840;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2786-51-8, 5-Chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2786-51-8

General procedure: A mixture of benzothiazole 1a (67.5 mg, 0.5 mmol), cyclohexane-1,3-dione 2b (112 mg, 1 mmol), KH2PO4 (136 mg, 1 mmol), DMSO (2 mL) and water (2 mL) were placed into a 15 mL flask under air. The reaction mixture was stirred in oil bath for 3 days at 80 C. The progress of the reaction was monitored by TLC. When the reaction was complete, it was neutralised with a saturated KHCO3 aqueous solution, and extracted with ethyl acetate (3 ¡Á10 mL). The extract was washed with water (3 ¡Á 5 mL) and dried over anhydrous Na2SO4. After drying, it was concentrated under reduced pressure to give the crude product, which was further purified by silica-gel column chromatography to afford 2,3-dihydro-10H-phenothiazin-4 (1H)-ones 3b (93.2 mg, yield: 86%).

As the paragraph descriping shows that 2786-51-8 is playing an increasingly important role.

Reference£º
Article; Suliman, Ayman Mohammed Yousif; Li, Yanjun; Zhang, Shaonan; Yuan, Yu; Journal of Chemical Research; vol. 39; 11; (2015); p. 657 – 660;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica