Category: 28620-12-4

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S. In a Article£¬once mentioned of 28620-12-4, Recommanded Product: 28620-12-4

The synthesis and structural characterization of series of copper and silver homoleptic complexes [M(R-pyX)], M = Cu, Ag, X = S, Se; R = H, 3-CF3, 5-CF3 (not all combinations), is described. The copper compounds, as well as [Ag(pySe)] and [Ag(3-CF3-pySe)], were synthesised by electrochemical oxidation of anodic metal in a cell containing an acetonitrile solution of the corresponding proligand. The other homoleptic silver complexes were obtained by direct reaction between AgNO3 and the salt of the corresponding ligand in methanol. In addition, the reaction of the metal thiolate compounds with bis(diphenylphosphino)ethane (dppe) in acetone allowed the synthesis of heteroleptic compounds [M2(R-pyX)2(dppe)3]. The compounds obtained have been characterized by microanalysis, IR spectroscopy and mass spectrometry and, in cases where the complexes were sufficiently soluble, by 1H NMR spectroscopy. The proligands (3-CF3pySe)2 (1), (5-CF3-pySe)2 (2) and (5-CF3-pySe-DMF) (3) and the complexes [Cu(3-CF3-pyS)] (4), [Ag(3-CF3-pyS)] (5) and [Cu2(5-CF3-pyS)2(dppe)3] (6) were obtained as crystalline products and were studied by X-ray diffraction methods.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 28620-12-4. In my other articles, you can also check out more blogs about 28620-12-4

Reference£º
Thiazole | C3H7281NS – PubChem,
Thiazole | chemical compound | Britannica

28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 28620-12-4, Recommanded Product: 28620-12-4

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type2 diabetes and obesity. 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the intracellular conversion of inactive cortisone to cortisol. Selective 11beta-HSD1 inhibitors have shown beneficial effects in various conditions, including diabetes, dyslipidemia and obesity. A series of adamantyl ethanone pyridyl derivatives has been identified, providing potent and selective inhibitors of human 11beta-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11beta-HSD1 and are selective for this isoform, with no activity against 11beta-HSD2 and 17beta-HSD1. Structure-activity relationship studies reveal that an unsubstituted pyridine tethered to an adamantyl ethanone motif through an ether or sulfoxide linker provides a suitable pharmacophore for activity. The most potent inhibitors have IC50 values around 34-48nM against human 11beta-HSD1, display reasonable metabolic stability in human liver microsomes, and weak inhibition of key human CYP450 enzymes.

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type2 diabetes and obesity. 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the intracellular conversion of inactive cortisone to cortisol. Selective 11beta-HSD1 inhibitors have shown beneficial effects in various conditions, including diabetes, dyslipidemia and obesity. A series of adamantyl ethanone pyridyl derivatives has been identified, providing potent and selective inhibitors of human 11beta-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11beta-HSD1 and are selective for this isoform, with no activity against 11beta-HSD2 and 17beta-HSD1. Structure-activity relationship studies reveal that an unsubstituted pyridine tethered to an adamantyl ethanone motif through an ether or sulfoxide linker provides a suitable pharmacophore for activity. The most potent inhibitors have IC50 values around 34-48nM against human 11beta-HSD1, display reasonable metabolic stability in human liver microsomes, and weak inhibition of key human CYP450 enzymes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 28620-12-4. In my other articles, you can also check out more blogs about 28620-12-4

Reference£º
Thiazole | C3H7319NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 28620-12-4, An article , which mentions 28620-12-4, molecular formula is C7H4N2O3S. The compound – 6-Nitro-2-benzothiazolinone played an important role in people’s production and life.

The invention relates to the field of chemical synthesis, in particular discloses 2, 3, 4 – tri-acetyl – 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside and hydrolysis product of the synthesis. Its four b acylated fucose and 5 – trifluoromethyl – 2 – mercapto pyridine as the starting material, in order to contain phosphoryl complex functional ionic liquid as the reaction medium, to the Lewis acid as a catalyst, under microwave irradiation, and carry on the glycosidation reaction to prepare the 2, 3, 4 – tri-acetyl – 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside, obtained through hydrolysis 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – of the alpha – L – fucose pyranoside. Preparation 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside starting material is relatively cheap, synthetic means is simple, fast, for the functionalized ionic liquid may be reused, the cost is greatly reduced. (by machine translation)

The invention relates to the field of chemical synthesis, in particular discloses 2, 3, 4 – tri-acetyl – 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside and hydrolysis product of the synthesis. Its four b acylated fucose and 5 – trifluoromethyl – 2 – mercapto pyridine as the starting material, in order to contain phosphoryl complex functional ionic liquid as the reaction medium, to the Lewis acid as a catalyst, under microwave irradiation, and carry on the glycosidation reaction to prepare the 2, 3, 4 – tri-acetyl – 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside, obtained through hydrolysis 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – of the alpha – L – fucose pyranoside. Preparation 1 – (5 – trifluoromethyl – 2 – pyridyl) mercapto – fucosylation of the alpha – L – glucopyranoside starting material is relatively cheap, synthetic means is simple, fast, for the functionalized ionic liquid may be reused, the cost is greatly reduced. (by machine translation)

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 28620-12-4, help many people in the next few years., Application of 28620-12-4

Reference£º
Thiazole | C3H7295NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 28620-12-4. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 28620-12-4, Name is 6-Nitro-2-benzothiazolinone. In a document type is Patent, introducing its new discovery.

This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

If you are interested in 28620-12-4, you can contact me at any time and look forward to more communication.Electric Literature of 28620-12-4

Reference£º
Thiazole | C3H7276NS – PubChem,
Thiazole | chemical compound | Britannica

28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 28620-12-4, Computed Properties of C7H4N2O3S

The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels,and more particularly of channels Kv1.5, Kv4.3 or Kvl 1.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents -C(=O)-, or B represents CH when n=0 and D represents -CH2O- or when n=1 and D represents -O-, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts

The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels,and more particularly of channels Kv1.5, Kv4.3 or Kvl 1.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents -C(=O)-, or B represents CH when n=0 and D represents -CH2O- or when n=1 and D represents -O-, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C7H4N2O3S. In my other articles, you can also check out more blogs about 28620-12-4

Reference£º
Thiazole | C3H7289NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 28620-12-4, Name is 6-Nitro-2-benzothiazolinone,molecular formula is C7H4N2O3S, is a conventional compound. this article was the specific content is as follows.category: thiazole

Disclosed is a novel compound having an effect of inhibiting the production/secretion of beta-amyloid protein. A compound represented by the general formula (1) or a salt or a solvate of the compound or the salt; and a pharmaceutical agent comprising the compound, salt or solvate.

Disclosed is a novel compound having an effect of inhibiting the production/secretion of beta-amyloid protein. A compound represented by the general formula (1) or a salt or a solvate of the compound or the salt; and a pharmaceutical agent comprising the compound, salt or solvate.

Do you like my blog? If you like, you can also browse other articles about this kind. category: thiazole. Thanks for taking the time to read the blog about 28620-12-4

Reference£º
Thiazole | C3H7320NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 28620-12-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S. In a Article£¬once mentioned of 28620-12-4

Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds, which include a series of substituted thiophenol and substituted phenol derivatives of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(phenylsulfanyl)methyl]-1,3-dioxolane hydrochloride (3), in addition to smaller functionalized derivatives, continue our structure-activity studies by exploration of the aminothiophenol region (‘northeastern region’) in our original target structure azalanstat (1). In vitro, most of the compounds in this series were found to be highly potent inhibitors of the stress-induced isozyme HO-1 and the constitutive isozyme HO-2, showing only moderate selectivity for HO-1. Nevertheless, a few of the compounds displayed higher selectivity toward HO-1. None of the compounds having a larger appendage in the northeastern region were inhibitors of CYP2E1, whereas a compound having a relatively small fluorine substituent in this region did inhibit CYP2E1; all of the compounds tested exhibited high inhibitory potency against CYP3A1/3A2.

Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds, which include a series of substituted thiophenol and substituted phenol derivatives of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(phenylsulfanyl)methyl]-1,3-dioxolane hydrochloride (3), in addition to smaller functionalized derivatives, continue our structure-activity studies by exploration of the aminothiophenol region (‘northeastern region’) in our original target structure azalanstat (1). In vitro, most of the compounds in this series were found to be highly potent inhibitors of the stress-induced isozyme HO-1 and the constitutive isozyme HO-2, showing only moderate selectivity for HO-1. Nevertheless, a few of the compounds displayed higher selectivity toward HO-1. None of the compounds having a larger appendage in the northeastern region were inhibitors of CYP2E1, whereas a compound having a relatively small fluorine substituent in this region did inhibit CYP2E1; all of the compounds tested exhibited high inhibitory potency against CYP3A1/3A2.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 28620-12-4 is helpful to your research., Application of 28620-12-4

Reference£º
Thiazole | C3H7303NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S. In a Patent£¬once mentioned of 28620-12-4, Safety of 6-Nitro-2-benzothiazolinone

The present invention provides a compound having an excellent efficacy for controlling weeds. A dihydropyrone compound of formula (I): wherein m is 1, 2 or 3; n is an integer of any one of 1 to 5; X represents O, S, S(O) or S(O)2; R1 represents a hydrogen atom or a methyl group; R2 and R3 represents a hydrogen atom, an C1-6 alkyl group and the like; when X represents S, S(O) or S(O)2, R4 represents an C1-6 alkyl group, a C1-6 haloalkyl group, an C6-10 aryl group or a five- to six- membered heteroaryl group, and X represents O, S, S(O) or S(O)2, R4 represents an C6-10 aryl group or a five- to six- membered heteroaryl group; G represents a hydrogen atom and the like; Z represents a halogen atom, a cyano group, a nitro group, a phenyl group, an C1-6 alkyl group and the like; is useful as an active ingredient for herbicides.

The present invention provides a compound having an excellent efficacy for controlling weeds. A dihydropyrone compound of formula (I): wherein m is 1, 2 or 3; n is an integer of any one of 1 to 5; X represents O, S, S(O) or S(O)2; R1 represents a hydrogen atom or a methyl group; R2 and R3 represents a hydrogen atom, an C1-6 alkyl group and the like; when X represents S, S(O) or S(O)2, R4 represents an C1-6 alkyl group, a C1-6 haloalkyl group, an C6-10 aryl group or a five- to six- membered heteroaryl group, and X represents O, S, S(O) or S(O)2, R4 represents an C6-10 aryl group or a five- to six- membered heteroaryl group; G represents a hydrogen atom and the like; Z represents a halogen atom, a cyano group, a nitro group, a phenyl group, an C1-6 alkyl group and the like; is useful as an active ingredient for herbicides.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 28620-12-4 is helpful to your research., Safety of 6-Nitro-2-benzothiazolinone

Reference£º
Thiazole | C3H7287NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S. In a Article£¬once mentioned of 28620-12-4, Recommanded Product: 28620-12-4

Cyclic imines react with isocyanides and electron-deficient phenols to afford N-aryl piperidines and pyrrolidines in good yields (Ugi-Smiles couplings of cyclic imines). The starting imines were formed by oxidation with N-chlorosuccinimide followed by a base-induced dehydrochlorination.

Cyclic imines react with isocyanides and electron-deficient phenols to afford N-aryl piperidines and pyrrolidines in good yields (Ugi-Smiles couplings of cyclic imines). The starting imines were formed by oxidation with N-chlorosuccinimide followed by a base-induced dehydrochlorination.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 28620-12-4 is helpful to your research., Recommanded Product: 28620-12-4

Reference£º
Thiazole | C3H7321NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 28620-12-4. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 28620-12-4, Name is 6-Nitro-2-benzothiazolinone. In a document type is Article, introducing its new discovery.

Imidazole (QH) or pyrazolone (Q’H2) in QAuL or (LAu)2Q’ (where L is a tertiary phosphine is displaced by some acidic reagents HL, wherw HZ=terminal acetylene, imide, thiol, dithio acid, or HI, to give ZAuL.If Z- is not a soft ligand an adduct between the reagents is obtained, and this is formulated as a protonated species, e.g. +Z- (HZ=picric acid).In other cases the adduct is LAuZ*HQ (rather than LAuQ*HZ or a protonated species), in which the displaced QH is hydrogen-bonded to the product, as shown by the crystal structure of the adduct 1-methyl-2-(cyclohexylphosphinegoldthiolato)imidazole*2benzimidazole.In this species gold(I) is two-coordinated (P-Au-S 172.0(1), with Au-P and Au-S 2.292(3) and 2.331(3) Angstroem, respectively; the first benzimidazole is hydrogen-bonded to N(3) of the imidazole , and the second benzimidazole to the N(3) of the first, the inter-diazole N…H-N distance being 2.81 and 2.86(1) Angstroem, respectively.

Imidazole (QH) or pyrazolone (Q’H2) in QAuL or (LAu)2Q’ (where L is a tertiary phosphine is displaced by some acidic reagents HL, wherw HZ=terminal acetylene, imide, thiol, dithio acid, or HI, to give ZAuL.If Z- is not a soft ligand an adduct between the reagents is obtained, and this is formulated as a protonated species, e.g. +Z- (HZ=picric acid).In other cases the adduct is LAuZ*HQ (rather than LAuQ*HZ or a protonated species), in which the displaced QH is hydrogen-bonded to the product, as shown by the crystal structure of the adduct 1-methyl-2-(cyclohexylphosphinegoldthiolato)imidazole*2benzimidazole.In this species gold(I) is two-coordinated (P-Au-S 172.0(1), with Au-P and Au-S 2.292(3) and 2.331(3) Angstroem, respectively; the first benzimidazole is hydrogen-bonded to N(3) of the imidazole , and the second benzimidazole to the N(3) of the first, the inter-diazole N…H-N distance being 2.81 and 2.86(1) Angstroem, respectively.

If you are interested in 28620-12-4, you can contact me at any time and look forward to more communication.Application of 28620-12-4

Reference£º
Thiazole | C3H7317NS – PubChem,
Thiazole | chemical compound | Britannica