Category: 28620-12-4

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.28620-12-4, Name is 6-Nitro-2-benzothiazolinone, molecular formula is C7H4N2O3S. In a Article£¬once mentioned of 28620-12-4, Application In Synthesis of 6-Nitro-2-benzothiazolinone

(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N-thiophthalimides at 25 C within 1 h in the presence of 5?10 % Cu(OAc)2?H2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrophilic thiolation was extended to the introduction of trifluoromethylthio (SCF3), thiocyanate (SCN), and selenophenyl (SePh) groups. The utility of this method was shown in a seven-step synthesis of a potent cathepsin D inhibitor in 34 % overall yield.

(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N-thiophthalimides at 25 C within 1 h in the presence of 5?10 % Cu(OAc)2?H2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrophilic thiolation was extended to the introduction of trifluoromethylthio (SCF3), thiocyanate (SCN), and selenophenyl (SePh) groups. The utility of this method was shown in a seven-step synthesis of a potent cathepsin D inhibitor in 34 % overall yield.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 6-Nitro-2-benzothiazolinone, you can also check out more blogs about28620-12-4

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Thiazole | C3H7340NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 28620-12-4, Name is 6-Nitro-2-benzothiazolinone, Application In Synthesis of 6-Nitro-2-benzothiazolinone.

The synthesis, photophysical and photochemical properties of new peripherally (beta) tetra-substituted thioquinoline Zn(II) (2) and quaternized thioquinoline Zn(II) phthalocyanines (3) and quaternized fluoro functional thiopyridine Zn(II) (5) are described for the first time. These complexes (2, 3 and 5) have been synthesized and characterized by elemental analysis, IR, 1H NMR spectroscopy and electronic spectroscopy. Complexes 2, 4 and 6 have good solubility in organic solvents such as CHCl3, DCM, DMSO, DMF, THF and toluene and are not aggregated in all solvents (except for 2 in DMSO) within a wide concentration range. Complexes 3 and 5 showed very good solubility in water as well as DMSO and DMF. General trends are described for singlet oxygen, photodegradation, fluorescence quantum yields, triplet quantum yields and triplet life times of these complexes in DMSO (2, 4 and 6) and water (3 and 5). Complex 3 gave a very large triplet quantum yield in aqueous media (PhiT = 0.8 in water plus Triton X-100) and a reasonable triplet lifetime of 110 mus. Photophysical and photochemical properties of the phthalocyanines complexes 2-6 are very useful for PDT.

The synthesis, photophysical and photochemical properties of new peripherally (beta) tetra-substituted thioquinoline Zn(II) (2) and quaternized thioquinoline Zn(II) phthalocyanines (3) and quaternized fluoro functional thiopyridine Zn(II) (5) are described for the first time. These complexes (2, 3 and 5) have been synthesized and characterized by elemental analysis, IR, 1H NMR spectroscopy and electronic spectroscopy. Complexes 2, 4 and 6 have good solubility in organic solvents such as CHCl3, DCM, DMSO, DMF, THF and toluene and are not aggregated in all solvents (except for 2 in DMSO) within a wide concentration range. Complexes 3 and 5 showed very good solubility in water as well as DMSO and DMF. General trends are described for singlet oxygen, photodegradation, fluorescence quantum yields, triplet quantum yields and triplet life times of these complexes in DMSO (2, 4 and 6) and water (3 and 5). Complex 3 gave a very large triplet quantum yield in aqueous media (PhiT = 0.8 in water plus Triton X-100) and a reasonable triplet lifetime of 110 mus. Photophysical and photochemical properties of the phthalocyanines complexes 2-6 are very useful for PDT.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 6-Nitro-2-benzothiazolinone. In my other articles, you can also check out more blogs about 28620-12-4

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Thiazole | C3H7280NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28620-12-4,6-Nitro-2-benzothiazolinone,as a common compound, the synthetic route is as follows.

Compound 47 (0.5?mmol) was dissolved in 1?mL dry DMF. Potassium carbonate (0.75?mmol) and 1-bromopentyl chloride (1.2?mmol) were added to the solution. The mixture was stirred at 80?C overnight. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (10?mL) and washed with water (2?*?10?mL). The organic layer was dried over MgSO4 and evaporated under reduced pressure. The product was purified by silica gel column chromatography (dichloromethane/petroleum ether 50:50, v/v). A yellow powder was obtained: yield 69%; mp 55?+-?1?C; 1H NMR (CDCl3) delta 8.37 (d, J?=?2.3?Hz, 1H), 8.25 (dd, J?=?2.3; 8.9?Hz, 1H), 7.14 (d, J?=?8.9?Hz, 1H), 4.01 (t, J?=?7.5?Hz, 2H), 1.75 (m, 2H), 1.40 (m, 4H), 0.90 (t, J?=?7.0?Hz, 3H); LC-MS (APCI+) m/z 267.1 (MH+).

28620-12-4, 28620-12-4 6-Nitro-2-benzothiazolinone 641571, athiazole compound, is more and more widely used in various fields.

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Article; Leleu-Chavain, Natascha; Baudelet, Davy; Heloire, Valeria Moas; Rocha, Diana Escalante; Renault, Nicolas; Barczyk, Amelie; Djouina, Madjid; Body-Malapel, Mathilde; Carato, Pascal; Millet, Regis; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 347 – 362;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica