Category: 29182-42-1

In an article, published in an article, once mentioned the application of 29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate,molecular formula is C11H11NO2S, is a conventional compound. this article was the specific content is as follows.name: Ethyl 2-(benzo[d]thiazol-2-yl)acetate

Several lines of evidence support the hypothesis that c-Jun N-terminal kinase (JNKs) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, epilepsy) and inflammatory disorders (multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases). Screening of our internal compound collection for inhibitors of JNK3 led to the identification of (benzothiazol-2-yl)acetonitrile derivatives as potent and selective JNK1, -2, -3 inhibitors. Starting from initial hit 1 (AS007149), the chemistry and initial structure-activity relationship (SAR) of this novel and unique kinase inhibitor template were explored. Investigation of the SAR rapidly revealed that the benzothiazol-2-ylacetonitrile pyrimidine core was crucial to retain a good level of potency on rat JNK3. Therefore, compound 6 was further optimized by exploring a number of distal combinations in place of the chlorine atom. This led to the observation that the presence of an aromatic group, two carbons away from the aminopyrimidine moiety and bearing substituents conferring hydrogen bond acceptor (HBA) properties, could improve the potency. Further improvements to the biological and biopharmaceutical profile of the most promising compounds were performed, resulting in the discovery of compound 59 (AS601245). The in vitro and in vivo anti-inflammatory potential of this new JNK inhibitor was investigated and found to demonstrate efficacy per oral route in an experimental model of rheumatoid arthritis (RA).

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Reference：
Thiazole | C3H7840NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S. In a Article，once mentioned of 29182-42-1, Recommanded Product: Ethyl 2-(benzo[d]thiazol-2-yl)acetate

We describe the synthesis of a number of 1,3-azol-2-yl-, 1,3-benzazol-2-yl-, and azinyl-based bis- (o-azaheteroaryl)methanes (LH, L- = Het2CH-) and their coordinating properties toward divalent transition metals (Zn, Cu, Co, Ni, Hg, Pd). This extended investigation includes both symmetrical and unsymmetrical ligands based on several substituted and/or unsubstituted thiazole, benzothiazole, benzoxazole, benzimidazole, pyridine, and quinoline derivatives. Depending on the structure and electron properties of the ligand, a vast set of neutral chelates ML2 were obtained, where the ligand is present in its carbanionic form L-. Additionally, we have prepared salt complexes [M(LH)n]-Xm, where the ligand is present as a neutral system. Neutral chelates were typically obtained by the reaction of the ligand with metal acetates in alcoholic solution; salt complexes were formed by reaction with other metal salts such as chlorides. By exploring the coordinating properties of several bisheteroarylmethane ligands based on heteroaromatics of variable pi-electron structure and substitution pattern, we demonstrate that the formation of neutral chelates is strictly dependent on the electron-withdrawing capacity (charge demand) of the heteroaromatic moiety. The latter primarily dictates the efficiency by which the negative charge of the anionic ligand L- is stabilized by delocalization in ML2 and, therefore, the stability of the chelate itself. On the basis of the large number and the variable nature of the nitrogen ligands used, we confirm the general validity of the charge-demand-dependent formation of chelates. This key factor can therefore be used for the efficient design of new pi-deficient heteroaromatic nitrogen ligands in chelates of great potential in many synthetic, catalytic, and technological fields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: Ethyl 2-(benzo[d]thiazol-2-yl)acetate. In my other articles, you can also check out more blogs about 29182-42-1

Reference：
Thiazole | C3H7821NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S. In a Article，once mentioned of 29182-42-1, Recommanded Product: 29182-42-1

The N-3 and N-2 methylated 1,2,3-thiadiazolium tetrafluoroborates 3 and 4 react with aliphatic activated methylene ketones and esters in the presence of a base to give the substitution products 7 – 11 and 18 – 24.Under similar conditions activated methylene azoles afford products formulated by NMR analysis as N-S…O rotamers (25, 26), N-S…N rotamers (12 – 15, 27 – 29), or a mixture of both (16, 17, 30).The X-ray crystal structure analysis of product 21, derived from the thiadiazolium salt 4 and 2,2-dimethyl-1,3-dioxane-4,6-dione, reveals a nearly linear N-S…O sequence (169 deg) and a short S…O contact (2.37/2.34 Angstroem) for the two independent molecules.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 29182-42-1 is helpful to your research., Recommanded Product: 29182-42-1

Reference：
Thiazole | C3H7834NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S. In a Article，once mentioned of 29182-42-1, Computed Properties of C11H11NO2S

Various 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6 -carboxylic acid derivatives were synthesized from 2-aminothiophenol by a five-step reaction, evaluated for in-vitro and in-vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB), and Mycobacterium smegmatis (MC2), and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. smegmatis. Among the thirty-four synthesized compounds, 2-(3-(diethylcarbamoyl)piperidin-1-yl)-)-3-fluoro-5,12-dihydro-5-oxobenz othiazolo[3,2-a]quinoline-6-carboxylic acid (7l) was found to be the most active compound in vitro with MIC of 0.18 and 0.08 muM against MTB and MTR-TB, respectively. Compound 7l was found to be 2 and 570 times more potent than isoniazid against MTB and MDR-TB, respectively. In the in-vivo animal model 7l decreased the bacterial load in lung and spleen tissues with 2.78 and 3.12 – log 10 protections, respectively, at the dose of 50 mg/kg body weight.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: 29182-42-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 29182-42-1, in my other articles.

Reference：
Thiazole | C3H7823NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S. In a Patent，once mentioned of 29182-42-1, Recommanded Product: 29182-42-1

The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: 29182-42-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 29182-42-1, in my other articles.

Reference：
Thiazole | C3H7833NS – PubChem,
Thiazole | chemical compound | Britannica

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Microwave-assisted facile condensation of ethyl 2-benzimidazoleacetates or ethyl 2-benzothiazoleacetates with o-diaminopyridines under solvent-free condition has afforded asymmetric diheteroarylmethanes in excellent yields. The synthetic route is optimized and all the reported compounds are fully characterized.

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Reference：
Thiazole | C3H7852NS – PubChem,
Thiazole | chemical compound | Britannica

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Due to the similar structure and reactivity of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), the simultaneous discrimination of Cys over Hcy and GSH by a single fluorescent sensor is still a great challenge. In this work, a benzothiazole-pyimidine-based boron difluoride complex (BPB) was developed as a new fluorescent sensor for Cys. The sensor exhibits a highly selective “turn-on” response to cysteine over Hcy, GSH and other amino acids in aqueous solution at physiological pH. The observed pseudo-first-order rate constant for the reaction of BPB with Cys was calculated to be about 0.062min-1. The detection limit of this sensor for Cys was determined to be 332nm, and bioimaging of exogenous Cys by this sensor was successfully applied in living cells, thus indicating that this sensor holds great potential for biological applications. A not so typical response: A fluorescent Cys sensor that featured a highly selective “turn-on” response to cysteine over Hcy, GSH, and other amino acids was developed.

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Reference：
Thiazole | C3H7857NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S. In a Article，once mentioned of 29182-42-1, Product Details of 29182-42-1

Herein, we give the very first example for the development of a fluorogenic molecular probe that combines the two-point binding specificity of biarsenical-based dyes with the robustness of bioorthogonal click-chemistry. This proof-of-principle study reports on the synthesis and fluorogenic characterization of a new, double-quenched, bis-azide fluorogenic probe suitable for bioorthogonal two-point tagging of small peptide tags by double strain-promoted azide-alkyne cycloaddition. The presented probe exhibits remarkable increase in fluorescence intensity when reacted with bis-cyclooctynylated peptide sequences, which could also serve as possible self-labeling small peptide tag motifs. The first example of a fluorogenic molecular probe has been developed that combines the two-point binding specificity of biarsenical-based dyes with the robustness of bioorthogonal click-chemistry. The new, double-quenched, bis-azide fluorogenic probe can bind to small bis-cyclooctynylated peptide tags through a double strain-promoted click reaction (see figure; SPAAC=strain-promoted alkyne-azide cycloaddition). The probe exhibits remarkable increase in fluorescence intensity with peptide sequences that can serve as possible self-labeling small peptide tags.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 29182-42-1, you can also check out more blogs about29182-42-1

Reference：
Thiazole | C3H7854NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 29182-42-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate

Accelerated proliferation of solid tumor and hematologic cancer cells is linked to accelerated transcription of rDNA by the RNA polymerase I (Pol I) enzyme to produce elevated levels of rRNA (rRNA). Indeed, upregulation of Pol I, frequently caused by mutational alterations among tumor suppressors and oncogenes, is required for maintenance of the cancer phenotype and forms the basis for seeking selective inhibitors of Pol I as anticancer therapeutics. 2-(4-Methyl-[1,4]diazepan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza-benzo[c] fluorene-6-carboxylic acid (5-methyl-pyrazin-2-ylmethyl)-amide (CX-5461, 7c) has been identified as the first potent, selective, and orally bioavailable inhibitor of RNA Pol I transcription with in vivo activity in tumor growth efficacy models. The preclinical data support the development of CX-5461 as an anticancer drug with potential for activity in several types of cancer.

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Reference：
Thiazole | C3H7863NS – PubChem,
Thiazole | chemical compound | Britannica

29182-42-1, Name is Ethyl 2-(benzo[d]thiazol-2-yl)acetate, molecular formula is C11H11NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 29182-42-1, SDS of cas: 29182-42-1

Amino acid derivatives in organic synthesis, Part 4 [1]: Facile synthesis of heterocycles containing a glycine residue

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition – intracyclization synthetic pathway. Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7].

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 29182-42-1. In my other articles, you can also check out more blogs about 29182-42-1

Reference：
Thiazole | C3H7843NS – PubChem,
Thiazole | chemical compound | Britannica