Category: 29198-43-4

Application of 29198-43-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 29198-43-4, Name is 2-Benzothiazolecarboxamide, molecular formula is C8H6N2OS. In a Article，once mentioned of 29198-43-4

Background: Influenza is a common respiratory tract infection caused by RNA-virus of the family Orthomyxoviridae; influenza virus, causing variety of symptoms including fever, nasal secretions, cough, muscle pain and pneumonia. It is classified into three distinct types A, B & C. Many 1,3,4-thiadiazoles, 1,3,4-oxadiazoles and 1,2,4-triazoles have showed broad spectrum of biological activities. These heterocycles are considered lead for their high antiviral activity against wide range of viruses. Methods: Research and online content related to chemistry of anti-influenza agents have been reviewed, five schemes were applied to obtain the target compounds, then these compounds underwent in vitro anti-influenza screening. Results: Thirty novel compounds were in vitro screened against the highly pathogenic avian influenza H5N1 virus in MDCK cells. Amantadine was used as control drug. Six compounds showed excellent activity (79-100 % virus inhibition) namely 6c, 14b, 14c, 19b, 30b, 30e with 14c being the most active compound. Five compounds exhibited moderate inhibition (44-70%) namely 5c, 6b, 23a, 23b, 30c. Conclusion: From the previous results, we found that presence of the triazole ring decreased the antiviral activity. While compound 19b that contains benzimidazole nucleus showed excellent inhibition. Presence of the thiadiazole ring greatly affected the activity in different ways according to the substitution on the ring. Moving to the oxadiazole series 14a-c, 16, 28b,c and 30a-f, the change in substitutions greatly affected the antiviral activity. Presence of 4-tolyl or 4-chlorophenyl at position 5 of the oxadiazole greatly enhanced the activity in 14b,c.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 29198-43-4 is helpful to your research., Application of 29198-43-4

Reference：
Thiazole | C3H2341NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 29198-43-4, C8H6N2OS. A document type is Patent, introducing its new discovery., name: 2-Benzothiazolecarboxamide

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Interested yet? Keep reading other articles of 29198-43-4!, name: 2-Benzothiazolecarboxamide

Reference：
Thiazole | C3H2333NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29198-43-4, Name is 2-Benzothiazolecarboxamide, COA of Formula: C8H6N2OS.

A number of S-(benzimidazol-2-ylmethyl) N-substituted-dithiocarbamates (IV) have been synthesized by the condensation of ammonium salts (III) of N-substituted dithiocarbamic acids with different 2-chloromethylbenzimidazoles (II).A similar condensation of II with sulphanilamides (V) affords N1-substituted-N4-(benzimidazol-2-ylmethyl)sulphanilamides (VI).Both the series of the compounds (IV and VI) have been screened for their bactericidal and fungicidal activities.Their structure elucidation is based on analytical and spectral data.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C8H6N2OS. In my other articles, you can also check out more blogs about 29198-43-4

Reference：
Thiazole | C3H2349NS – PubChem,
Thiazole | chemical compound | Britannica

29198-43-4, Name is 2-Benzothiazolecarboxamide, molecular formula is C8H6N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 29198-43-4, category: thiazole

In this study, novel specific PET radioligands containing the 4-(4-fluorobenzyl)piperidine moiety and selectively antagonistic for the NR2B subunit containing NMDA receptors were developed. Two antagonists, RGH-896 (1a) and 4-(4-fluorobenzyl)piperidinyl-1-methyl-2-benzimidazol-5-ol (2a), belonging to two different structural families, were radiolabeled by an aromatic nucleophilic radiofluorination followed by a reduction of the para-position carbonyl function. Radiotracers [18F]1a, [18F]2a or the pattern 4-(4-[18F]-fluorobenzyl)piperidine ([18F]6) demonstrated an identical in vivo behavior with high accumulation of radioactivity in bone and cartilage which would suggest a radiodefluorination of the radiotracers. The identification of metabolites from 6 by LC-MS-MS confirmed the significant degree of defluorination as a result of the in vivo hydroxylation in the benzyl ring. In conclusion, [18F]1a or [ 18F]2a are not suitable for imaging the NR2B NMDA receptors due to their poor brain penetration. We also argue for a cautious use of the radiolabeled pattern, 4-(4-[18F]-fluorobenzyl)piperidine, to develop PET radiotracers.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 29198-43-4. In my other articles, you can also check out more blogs about 29198-43-4

Reference：
Thiazole | C3H2339NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 29198-43-4, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.29198-43-4, Name is 2-Benzothiazolecarboxamide, molecular formula is C8H6N2OS. In a patent, introducing its new discovery.

Aggregation of alpha-synuclein (alpha-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good pi-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards alpha-Syn with IC50 down to 1.09 muM. The molecule is found binding in parallel to the NACore within NAC domain of alpha-Syn, interfering aggregation of NAC region within different alpha-Syn monomer, and further inhibiting or slowing down the formation of alpha-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit alpha-Syn aggregation.

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Reference：
Thiazole | C3H2342NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.29198-43-4, Name is 2-Benzothiazolecarboxamide, molecular formula is C8H6N2OS. In a Article，once mentioned of 29198-43-4, Quality Control of: 2-Benzothiazolecarboxamide

A series of 2-methylaminobenzimidazole derivatives (1-11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 29198-43-4 is helpful to your research., Quality Control of: 2-Benzothiazolecarboxamide

Reference：
Thiazole | C3H2346NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 29198-43-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29198-43-4, Name is 2-Benzothiazolecarboxamide

Title compounds (4a-p) were prepared by reacting corresponding 2-chloromethyl benzimidazole with carbon disulfide and various alkyl, aralkyl and heterocyclic amines in dimethylformamide. The newly synthesized compounds were characterized by IR, 1H NMR, MS and elemental analysis. All the compounds have been screened for antibacterial and antifungal activities.

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Reference：
Thiazole | C3H2332NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 29198-43-4, Name is 2-Benzothiazolecarboxamide,molecular formula is C8H6N2OS, is a conventional compound. this article was the specific content is as follows.COA of Formula: C8H6N2OS

A kind of by the represented by the following general formula 2 – (( (1H-Indol-3-yl) methoxy) methyl) – 1H-benzimidazole derivatives: Wherein the substituents in formula R 1, R 7 can be-H, -CH 3, -CH 2 CH 3, -CHCH=CH 2, -CH 2 Ph, -COCH 3, p-CH 3-C 6 H 4-SO 2-; R 2, R 3, R 4, R 5, R 6, R 8, R 9, R 10, R 11 can be-H, -CH 3, -CH 2 CH 3, -CHCH=CH 2, -CH 2 Ph, -COCH 3, -CF 3, -CCl 3, -CN, -NHCH 3, -NO 2, -OCH 3, -CH 2 NH 2, -COOCH 3, -CONHCH 3. The method of the invention is to to indole-3-methanol and its derivatives and 2-halo methylbenzimidazole and its derivatives or 3-halo methyl indole and its derivatives and benzimidazole-2-methanol and its derivatives as the reactant, and in proper solvent under the condition of the catalyst, by the one-step reaction to produce 2 – (( (1H-Indol-3-yl) methoxy) methyl) – 1H-benzimidazole derivatives. Preparation of the compounds is as follows: Wherein X groups in the formula represents a chlorine, bromine or iodine. (by machine translation)

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Reference：
Thiazole | C3H2352NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.29198-43-4, Name is 2-Benzothiazolecarboxamide, molecular formula is C8H6N2OS. In a Article，once mentioned of 29198-43-4, Computed Properties of C8H6N2OS

A series of novel 5-amino-1,3,4-thiadiazole-2-thiol and 1,3,4-thiadiazole-2,5-dithiol derivatives of benzimidazole were synthesized through nucleophilic substitution reaction of 5-substituted-2-(chloromethyl)-1H-benzimidazole, structures of the synthesized compounds were proved by spectral methods of analysis (FT-IR, 1H and 13C NMR). All the target compounds were screened for their antibacterial activity toward gram-negative (E.coli, P. aeruginosa) and Gram-positive (B. subtilis, S. aureus) bacteria, most of the synthesized derivatives exhibited good to moderate activity toward both Gram-positive (B. subtilis, S. aureus) and Gram-negative (E.coli, P. aeruginosa) bacteria.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C8H6N2OS, you can also check out more blogs about29198-43-4

Reference：
Thiazole | C3H2344NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 29198-43-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 29198-43-4, Name is 2-Benzothiazolecarboxamide

Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition

Novel series of 3-substituted 2,6-difluorobenzamide derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their in vitro antibacterial activity against various phenotype of Gram-positive and Gram-negative bacteria, and their cell division inhibitory activity against three representative strains. As a result, 3-chloroalkoxy derivative 7, 3-bromoalkoxy derivative 12 and 3-alkyloxy derivative 17 were found to exhibit the best antibacterial activity against Bacillus subtilis with MICs of 0.25?1 mug/mL, and good activity (MIC < 10 mug/mL) against both susceptible and resistant Staphylococcus aureus. Additionally, all the three compounds displayed potent cell division inhibitory activity with MIC values of below 1 mug/mL against Bacillus subtilis and Staphylococcus aureus. If you are hungry for even more, make sure to check my other article about 29198-43-4. Synthetic Route of 29198-43-4

Reference：
Thiazole | C3H2336NS – PubChem,
Thiazole | chemical compound | Britannica