Category: 2941-58-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

A mixture of 2-bromo-6-methoxy-benzothiazole (1.14 g), 5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyridin-2-amine (1.23g, 1.2 eq.)5 Pd(dppf)Cl2*DCM (170 mg, 0.05 eq.) and 2.0 M aq. K2CO3 (10 ml, 4 eq.) in DMF(20 ml) was heated at 80 0C for 2 h under o argon while stirring. Ethyl acetate (200 ml) was subsequently added before concentrating the sol. onto diatomaceous earth in vacuo. Purification by flash chromatography (DCM:methanol, 99:1 to 95:5) provided the title compound (730 mg) as a yellow solid. 1H NMR delta 8.56 (d, 1 H) 7.96 (dd, 1 H) 7.82 (d, 1 H) 7.64 (d, 1 H) 7.07 (dd, 1 H) 6.67 (br. s, 2 H) 6.55 (d, 1 H) 3.83 (s, 3 H); MS m/z (M+H) 258.1., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; WO2007/86800; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The corresponding 2-bromobenzothiazoles 10, 12-15 (0.66mmol, 1equiv) and the corresponding phenylboronic acid pinacol ester (0.79mmol, 1.2equiv) were dissolved in anhydrous DMF in the presence of K2CO3 (6.0equiv). After 1h under argon bubbling, Pd(dppf)Cl2·CH2Cl2 (0.033mmol, 0.05equiv) was introduced and the mixture was stirred at 80C or under microwave irradiation (monitoring by TLC or by GC-MS). Later, the mixture was then filtered on Celite, concentrated and dissolved in 4mL of 1N MeOH/HCl. Then 75mL of Et2O were introduced and a colour powder was isolated by filtration. The precipitate was poured into water and pH adjusted to 6. The expected compounds were isolated by filtration and purity was checked by HPLC., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde; Tetrahedron; vol. 69; 35; (2013); p. 7345 – 7353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromo-6-methoxybenzothiazole (0.67g) in drydichloromethane (30ml) at ambient temperature under an atmosphere of nitrogen wasadded dropwise a solution of boron tribromide in dichloromethane (5.5ml, 1M). Themixture was stirred for 2 hours at ambient temperature, stored for 2 days then poured intowater. The organic phase was separated, washed with water, dried over magnesiumsulphate then evaporated under reduced pressure to give 2-bromo-6-hydroxy-benzothiazole as a pale pink solid, 0.60g, m.p. 203-204C., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SYNGENTA LIMITED; WO2004/108663; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

Under N2, in a sealed tube, to 22 (19.7 mmol) in DMF 50 ml, 1-iodo-4-nitrobenzene (21.6 mmol), cesium carbonate (19.6 mmol), palladium acetate (0.98 mmol), copper bromide (0.2 mmol) and tributylphosphine (1.9 mmol) were added. The reaction was stirred at 150 C. overnight and, after cooling to room temperature, the mixture was extracted with ethyl acetate. The organic layer was then washed (3 times) with water, dried over Na2SO4 and the solvent removed via a rotary evaporator. The residue was purified by chromatography on silica gel using 9:1 hexane/ethyl acetate as the eluent to yield 4.62 g (81%) of 23 as a yellow solid. NMR 1H (DMSO), delta=3.83 (3H, s); 7.21 (1H, J=8.6 Hz); 7.73 (s, 1 H); 8.04 (2H, d, J=8.7 Hz); 8.25 (1H, d, J=8.6 Hz); 8.35 (2H, d, J=8.7 Hz). NMR ?13C(DMSO), delta=55.3; 104.7; 115.7; 1 16.7; 123.4; 124.1 (2C); 124.5; 127.8; 128.6 (2C); 144.0; 147.5; 157.5., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Tamagnan, Gilles D.; Alagille, David; Costa, Herve Da; US2007/258887; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-6-methoxy-l,3-benzothiazole (0.300 g, 1.23 mmol), 5-(4,4,5- trimethyl-l,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (0.326 g, 1.47 mmol), Pd(dppf)Cl2*DCM (50 mg, 0.061 mmol) and 2 M aq. K2CO3 (3 mL) in DMF (7 mL) was o stirred under argon at 80 C for 1 h. The reaction mixture was allowed to reach rt and was filtered through silica. The filter cake was washed with DCM and DMF. The filtrate was concentrated under vacuum. Flash chromatography (Heptane/EtOAc gradient) of the residue gave the title compound (0.171 g) as a yellow solid. 1H NMR delta ppm 8.83 (s, 2 H) 7.87 (d, 1 H) 7.70 (d, 1 H) 7.35 (br s, 2 H) 7.11 (dd, 1 H) 3.84 (s, 3 H); MS m/z (M+H) s 259., 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2007/86800; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a stined solution of 2-bromo-6-methoxybenzo[d]thiazole (8.00 g, 32.8 mmol) in dichloromethane (20 mL) at 15 C was added tribromoborane (9.1 mL, 98 mmol) dropwise. The resulting mixture was heated at 40 C for 6 h then poured into ice water. The precipitate was filtered and the filtrate was extracted with dichloromethane (40 mL x 3). The precipitate and the organic layers were combined, dried over Na2504,and concentratedto give the title compound.MS: m/z = 229.9, 231.9 (M + 1). ?H NMR (400 MHz, CD3OD): oe7.74 (d, J= 8.8 Hz, 1H), 7.28 (d,J=2.4Hz, 1H),7.00(dd,J,=8.8Hz, J2=2.4Hz, 1H)., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an 8 mL screw cap vial was added a solution of 3-benzyl-6-mercapto-5- [METHYL-LH-PYRIMIDINE-2,] 4-dione, (0.025 g, 0.1 mmol) in dimethylformamide (1 [ML),] a solution of 2-bromo-6-methoxybenzothiazole (0.15 mmol) in dimethylformamide (0.3 mL) and diisopropylethylamine (0.05 mL, 0.3 mmol). The vial was capped and the reaction mixture was shaken for 24 hours at [100C.] The solvent was removed under vacuum. Purification was carried out via reverse- phase HPLC (ODS AC-18, [5] [T,] 30 mm [X100] mm, 3% n-propanol in acetonitrile and [3%] n-propanol in water 10 % to [90%] over 10 minutes) to give 3-benzyl-6- (6- [METHOXY-BENZOTHIAZOL-2-YLAMINO)-5-METHYL-1H-PYRIMIDINE-2,] 4-dione. MS [(APCI),] m/z [( [M+H] +)] 395.1.

2941-58-4, The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/14868; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-bromo-6- methoxybenzo[d]thiazole (0.90 g; 3.7 mmol) was dissolved in CH2CI2 (50 mL). BBr3 (1M in CH2C12, 16 mL, 16 mmol) was added slowly. White precipitate formed immediately. After overnight, HPLC showed complete conversion. Excess CH2CI2 (200 mL) and brine (100 mL) were added. White precipitate formed immediately. The mixture was stirred at RT for 2 hours, until most solid dissolved. The organic layer was separated, and aqueous layer extracted with 2 x 100 mL CH2CI2. The combined organic solution was dried over MgS04. The solvent was removed to afford 0.71 g of product. Yield 83%., 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

Reference：
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; CAI, Lisheng; PIKE, Victor W.; WO2013/40183; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

2-Bromo-6-methoxybenzo [d] thiazole (555 mg, 2.28 mmol) was dissolved in methylene chloride (10 mL) at room temperature under an argon atmosphere. To the resulting solution, 1 M boron tribromide methylene chloride solution (4 mL) was added at room temperature. The resulting mixture was stirred under an argon atmosphere at room temperature for 7 hours.The reaction mixture was added to ice water and then extracted with chloroform (3 × 30 mL). The combined organic layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel 80 g; hexane: ethyl acetate (3: 1)) to give 2-bromobenzo [d] thiazol-6-ol (521 mg, yield 99 %) As a brown solid. The measured physical properties of the product are as follows., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; KEIO UNIVERSITY; SAITOH, TSUYOSHI; NISHIYAMA, SHIGERU; IOKA, SHUJI; MAKI, SHOJIRO; NIWA, HARUKI; (19 pag.)JP6095208; (2017); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica