9/27/21 News Can You Really Do Chemisty Experiments About 6-Methoxybenzo[d]thiazole

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A one-pot protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. This process is metal free and operationally simple. A series of 2-hetarylbenzothiazoles were prepared in moderate to good yield under mild conditions.

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Reference:
Thiazole | C3H7219NS – PubChem,
Thiazole | chemical compound | Britannica

Sep 2021 News Some scientific research about 6-Methoxybenzo[d]thiazole

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Ligand- and solvent-free catalytic conditions that harness a nanostructured?CuI catalyst encapsulated in TiO2 has been reported for C2-amination of azoles (benzothiazole, benzoxazole and thiazole). The reaction is highly regioselective. The catalyst is robust, inexpensive and can be recycled up to four times. This strategy was further used for the synthesis of a small molecule with anti-HIV and anti-tumor properties.

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Reference:
Thiazole | C3H7176NS – PubChem,
Thiazole | chemical compound | Britannica

Sep 2021 News Discovery of 6-Methoxybenzo[d]thiazole

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Visible light along with 5 mol % eosin B catalyzed the first direct C-H phosphorylation of thiazole derivatives with diarylphosphine oxides by a photoredox process in the absence of an external oxidant. The scope of thiazoles and phosphine oxides was further investigated, as was functional group tolerance. The general and operational simplicity provides a novel metal and oxidant-free alternative for the formation of heteroaryl-P bonds, and only molecular hydrogen is generated as a byproduct.

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Reference:
Thiazole | C3H7129NS – PubChem,
Thiazole | chemical compound | Britannica

Sep 2021 News A new application about 6-Methoxybenzo[d]thiazole

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Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with alpha-oxocarboxylic acids was developed through an sp2 C-H bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C-H bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives.

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Reference:
Thiazole | C3H7191NS – PubChem,
Thiazole | chemical compound | Britannica

Sep 2021 News Final Thoughts on Chemistry for 6-Methoxybenzo[d]thiazole

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beta-Azolyl propanoic acid derivatives are frequently found in biologically active molecules and pharmaceuticals. Here, we report the oxidative heteroarylation of unactivated C(sp3)-H bonds with azole C(sp2)-H bonds via copper or nickel catalysis with the aid of removable bidentate auxiliary, which provides a rapid pathway to beta-azolyl propanoic acid derivatives. A variety of azoles such as oxazole, benzoxazole, thiazole, benzothiazoles, benzimidazole, purine, and even [1,2,4]triazolo[1,5-a]pyrimidine could be engaged in this protocol.

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Reference:
Thiazole | C3H7193NS – PubChem,
Thiazole | chemical compound | Britannica

2-Sep-2021 News Archives for Chemistry Experiments of 6-Methoxybenzo[d]thiazole

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Chelate resins, which are polystyrene-divinylbenezene-based polymers bearing iminodiacetic acids or polyamines as ligands, supported copper catalysts (Cu/CR11 or Cu/CR20) in effectively catalyzing the ring cleaving S-arylation of benzothiazole with aryl iodides or aryl bromides in the presence of lithium tert-butoxide in aqueous 2-propanol.

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Reference:
Thiazole | C3H7192NS – PubChem,
Thiazole | chemical compound | Britannica

02/9/2021 News Archives for Chemistry Experiments of 6-Methoxybenzo[d]thiazole

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N-heterocyclic carbene (NHC) copper(I) complexes based on imidazol-2-ylidene and 1,2,3-triazol-5-ylidene catalyzed the direct C-H thiolation of benzothiazoles and benzoxazoles with aryl and alkyl thiols to give 2-aryl and 2-alkylthiobenzothiazoles in moderate-to-good yields. The NHC copper(I) complex [(IPr)CuI] was the most effective catalyst for the reaction among the NHC-Cu(I) complexes examined in this study.

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Reference:
Thiazole | C3H7175NS – PubChem,
Thiazole | chemical compound | Britannica

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B(C6F5)3 combined with atmospheric CO2 was found to be highly effective for the cyclization of ortho-substituted aniline derivatives with N,N-dimethylformamide (DMF), and a series of N-containing heterocycles including benzothiazoles, benzimidazoles, quinazolinone and benzoxazole were obtained in good to excellent yields.

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Reference:
Thiazole | C3H7195NS – PubChem,
Thiazole | chemical compound | Britannica

Archives for Chemistry Experiments of 2942-13-4

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A convenient one-pot palladium-catalyzed cascade process for the preparation of both benzoxazoles and benzothiazoles has been developed. While these reactions proceed to give similar compounds the mechanisms governing the processes are different as are the experimental conditions employed.

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Reference:
Thiazole | C3H7235NS – PubChem,
Thiazole | chemical compound | Britannica

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Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide (12u) reduced blood glucose excursion in an oral glucose tolerance test.

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Reference:
Thiazole | C3H7172NS – PubChem,
Thiazole | chemical compound | Britannica