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Rhodium-catalyzed direct oxidative cross-coupling of 2-aryl pyridine with benzothiazoles

A rhodium-catalyzed cross-coupling reaction of 2-aryl pyridine and benzothiazoles via dual C-H bond functionalization has been developed in the presence of copper salts. The reaction system provides a new approach to heterobiaryl species, which are ubiquitous in pharmaceuticals and nature products.

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Reference:
Thiazole | C3H7214NS – PubChem,
Thiazole | chemical compound | Britannica

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A novel 3 – (benzothiazolyl) imidazo [1, 2 – a] pyridine synthesis of bis-heterocyclic compounds (by machine translation)

The invention relates to the field of pharmaceutical chemistry, in particular to a novel 3 – (benzothiazolyl) imidazo [1, 2 – a] pyridine synthesis of bis-heterocyclic compounds, and its application to inhibit cancer cell proliferation. The invention relates to a benzothiazole compound and imidazopyridine compound as the initiator and, through the double-C – H key activation way to synthesize 3 – benzo thiazolyl imidazopyridine compounds. The method this not only further expand the double-C – H on the basis of the key activation of chemical research work, more conducive to the double-heterocyclic compound of the pharmaceutical research, to promote the countries to achieve double-heterocyclic compound pharmaceutical of the originai innovation to provide a reference for the progress of the work. (by machine translation)

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Reference:
Thiazole | C3H7147NS – PubChem,
Thiazole | chemical compound | Britannica

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A Sc(OTf)3-catalyzed dearomative [3 + 2] cycloaddition of benzazoles with donor-acceptor oxiranes through chemoselective C-C bond cleavage of oxiranes was developed under mild conditions. This reaction provides an efficient method to construct benzazolo[3,2-c]oxazole compounds in good yields and with high diastereoselectivity. The reaction has a general substrate scope, and the donor-acceptor oxiranes with electron-donating and electron-withdrawing groups on the aromatic ring afforded the desired cycloadducts.

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Reference£º
Thiazole | C3H7213NS – PubChem,
Thiazole | chemical compound | Britannica

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A Pd-catalyzed direct cross-coupling of 3-bromocoumarins with heteroarenes provided an efficient route to synthesizing 3-heteroarylcoumarins. The reaction scope for the transformation was fairly broad, affording modest to good yields of various 3-heteroarylcoumarin scaffolds, which are privileged structures and prevalent motifs in many biologically active compounds and fluorophores. The Royal Society of Chemistry 2012.

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Reference£º
Thiazole | C3H7217NS – PubChem,
Thiazole | chemical compound | Britannica

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2942-13-4, Name is 6-Methoxybenzo[d]thiazole, molecular formula is C8H7NOS. In a Article£¬once mentioned of 2942-13-4, Safety of 6-Methoxybenzo[d]thiazole

2-Aminothiazoles, 2-aminobenzazoles, and 3-amino-1,2,4-triazines were deaminated using nitric oxide (NO) in the presence of a catalytic amount of oxygen to afford corresponding unsubstituted heterocycles in good yields.

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Reference£º
Thiazole | C3H7240NS – PubChem,
Thiazole | chemical compound | Britannica

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2942-13-4, Name is 6-Methoxybenzo[d]thiazole, molecular formula is C8H7NOS. In a Article£¬once mentioned of 2942-13-4, Recommanded Product: 2942-13-4

17beta-HSD1 is a novel target for the treatment of estrogen-dependent diseases, as it catalyzes intracellular estradiol formation. Starting from two recently described compounds, highly active and selective inhibitors were developed. Benzoyl 6 and benzamide 17 are the most selective compounds toward 17beta-HSD2 described so far. They also showed a promising profile regarding activity in T47-D cells, selectivity toward ERalpha and ERbeta, inhibition of hepatic CYP enzymes, metabolic stability, and inhibition of marmoset 17beta-HSD1 and 17beta-HSD2.

17beta-HSD1 is a novel target for the treatment of estrogen-dependent diseases, as it catalyzes intracellular estradiol formation. Starting from two recently described compounds, highly active and selective inhibitors were developed. Benzoyl 6 and benzamide 17 are the most selective compounds toward 17beta-HSD2 described so far. They also showed a promising profile regarding activity in T47-D cells, selectivity toward ERalpha and ERbeta, inhibition of hepatic CYP enzymes, metabolic stability, and inhibition of marmoset 17beta-HSD1 and 17beta-HSD2.

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Reference£º
Thiazole | C3H7241NS – PubChem,
Thiazole | chemical compound | Britannica

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There is provided a compound of Formula I 1 wherein each T is independently selected from H, hydrocarbyl, ?F?R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C?O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

There is provided a compound of Formula I 1 wherein each T is independently selected from H, hydrocarbyl, ?F?R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C?O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

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Reference£º
Thiazole | C3H7135NS – PubChem,
Thiazole | chemical compound | Britannica

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2942-13-4, Name is 6-Methoxybenzo[d]thiazole, molecular formula is C8H7NOS. In a Article£¬once mentioned of 2942-13-4, Recommanded Product: 2942-13-4

A one-pot protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. This process is metal free and operationally simple. A series of 2-hetarylbenzothiazoles were prepared in moderate to good yield under mild conditions.

A one-pot protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. This process is metal free and operationally simple. A series of 2-hetarylbenzothiazoles were prepared in moderate to good yield under mild conditions.

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Reference£º
Thiazole | C3H7219NS – PubChem,
Thiazole | chemical compound | Britannica

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Reference of 2942-13-4. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 2942-13-4, Name is 6-Methoxybenzo[d]thiazole. In a document type is Article, introducing its new discovery.

The direct phosphorylation of (benzo)thiazoles with various H-phosphine oxides was realized by using K2S2O8 as the oxidant. A series of 2-phosphoryl (benzo)thiazoles were obtained in moderate to good yields.

The direct phosphorylation of (benzo)thiazoles with various H-phosphine oxides was realized by using K2S2O8 as the oxidant. A series of 2-phosphoryl (benzo)thiazoles were obtained in moderate to good yields.

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Reference£º
Thiazole | C3H7162NS – PubChem,
Thiazole | chemical compound | Britannica

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2942-13-4, Name is 6-Methoxybenzo[d]thiazole, molecular formula is C8H7NOS. In a Article£¬once mentioned of 2942-13-4, Formula: C8H7NOS

A one-pot protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. This process is metal free and operationally simple. A series of 2-hetarylbenzothiazoles were prepared in moderate to good yield under mild conditions.

A one-pot protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. This process is metal free and operationally simple. A series of 2-hetarylbenzothiazoles were prepared in moderate to good yield under mild conditions.

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Reference£º
Thiazole | C3H7219NS – PubChem,
Thiazole | chemical compound | Britannica