Category: 29927-08-0

New learning discoveries about 29927-08-0

29927-08-0, The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of acetoacetamide derivatives (3a-e) was carried out as shown in Scheme 1. 2,2,6-Trimethyl-1,3- dioxine-4-one (1) (2eq) and appropriate arylamine (2a-e) (1eq) were mixed and refluxed for about 2-4h in toluene. The progress of the reactions was checked by TLC. Upon completion of the reaction, the product was filtered, washed with small portions of petroleum ether. Further purification was performed by crystallization of obtained product in hot ethanol. Characteristics data for prepared N-(aryl)-3- oxobutanamides are as follows:

29927-08-0, The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ebadi, Ahmad; Khoshneviszadeh, Mehdi; Javidnia, Katayoun; Ghahremani, Mohammad Hossein; Firuzi, Omidreza; Miri, Ramin; Letters in drug design and discovery; vol. 14; 8; (2017); p. 885 – 897;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29927-08-0,5,6-Dimethylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: A 25 mL two-neck round-bottomed flask was charged with 2-aminobenzothiazole (1a, 180 mg,1.2 mmol), methyl acetoacetate (2a, 108 muL, 1.0 mmol), in 3 mL of CBrCl3/MeCN 1:9 (v/v) solvent mixture. KOt-Bu(224 mg, 2.0 mmol) was added slowly at room temperature and the reaction mixture was stirred under reflux for 16 h. Upon completion, the reaction mixture was diluted with 30 mL of ethyl acetate, filtered through a short pad of silica gel and washed down with an additional 60 mL ethyl acetate. The filtrate was washed with distilled water (3 ¡Á 30 mL) and the organic phase was dried with anhydrous Na2SO4. After filtration,the solvent was removed by rotary evaporation and the residue was purified by column chromatography using hexane and ethyl acetate (v/v = 8:1) as eluent to afford 3a with 84%yield., 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Roslan, Irwan Iskandar; Ng, Kian-Hong; Chuah, Gaik-Khuan; Jaenicke, Stephan; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2739 – 2750;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29927-08-0,5,6-Dimethylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: To the solution of beta-naphthol (1mmol) in methanol were added respective substituted 2-aminobenzothiazole (1mmol) and the synthesized pyrazole aldehyde31 (1mmol). The reaction mixture was refluxed for 5h. The reaction was monitored by TLC and the advantage of this method is that a solid product (white ppt) was formed in the round bottom flask after completion of the reaction. The solid compound was collected by filtration and purified by column chromatography to obtain pure pyrazole linked benzothiazole-beta-naphthol derivatives in good to excellent yields., 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Md. Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 708 – 720;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Analyzing the synthesis route of 29927-08-0

29927-08-0, Big data shows that 29927-08-0 is playing an increasingly important role.

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-Aminobenzothiazole (0.30 g, 2.0 mmol) was dissolved in hot glacial acetic acid/propionic acid mixture (2:1, 6.0 ml) and was rapidly cooled in an ice-salt bath to -5 C. The mixture was then stirred for 2 h. at 0-5 C. The liquor was then added in portions during 30 min to a cold solution of nitrosyl sulfuric acid [prepared from sodium nitrite (0.15 g) and concentrated sulfuric acid (3 ml at 50 C)]. The mixture was stirred for an additional 2 h at 0 C. Excess nitrous acid was destroyed by the addition of urea. The resulting diazonium salt was cooled in salt/ice mixture. 2-methlyindole(0.26 g, 2.0 mmol) was dissolved in mixture of acetic acid/propionic acid solution (3:1, 8.0 ml) and cooled in salt/ice bath and then cold diazonium solution was added to this cooled solution by stirring in a dropwise manner. The solution was stirred at 0-5 C for 2 h. and pH of the reaction mixture was maintained at 4-6 by simultaneous addition of saturated sodium carbonate solution.The mixture was stirred for a further 1 h at 5 C. The resulting product was filtered, washed with water, dried and crystallized from ethanol mixture gave brown powder (yield: 0.29 g, 51%; m.p: 168-170 C), FT-IR (KBr) numax: 3345 (indole -NH), 3059 (aromatic C-H), 2969, 2920 (aliphatic C-H), 1605 (C=C) cm-1; 1HNMR (DMSO-d6/CDCl3): d 9.71 (b, indole -NH), 7.98 (1H,m), 7.37(1H,m), 7.30-7.15 (4H,m), 6.82 (2H,m), 2.36 (3H,s).Anal. Calcd. For C16H12N4S: C, 65.73; H, 4.14; N, 19.16; S, 10.97Found: C, 65.68; H, 4.19; N, 19.11; S, 10.92%.MS (m/z, 70 eV): 292.0 (M+), 277.0, 158.0, 130.0.

29927-08-0, Big data shows that 29927-08-0 is playing an increasingly important role.

Reference£º
Article; Sefero?lu, Zeynel; Kaynak, Filiz Betul; Ertan, Nermin; Ozbey, Suheyla; Journal of Molecular Structure; vol. 1047; (2013); p. 22 – 30;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica