Category: 30132-15-1

30132-15-1, 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (2-ami?o-benzothiazol-6-yl)-acetic acid (0.61 mmol, as prepared by Meyer et al. in J. Med. Chem. 1997, 40, 1060) in absolute etha?ol (10 mL) was treated with 3 drops of concentrated H2SO4 and. ca. 1 g of dry 4 A molecular sieves, and heated to reflux for 3 d. The reaction was concentrated to dryness in vacuo, partitioned between CHaCl2 and saturated aqueous NaHCO3, filtered, and phases separated. The aqueous layer was extracted with CH2CI2, and the combined organic layers were washed with water and brine, dried over Na2SO4, filtered, and the filtrate concentrated in vacuo giving the title compound as a yellow solid. 1H NMR (CDCI3) S 7.50 (IH, m), 7.41 (IH, d, J = 8.3 Hz), 7.20 (IH, dd, / = 8.2 Hz, 1.9 Hz), 4.15 (2H, q, J = 7.2 Hz), 3.65 (2H, s), 3.42 (4H, s [NH2 + H2O]), 1.26 (3H, t, J = 7.1 Hz). ESI-MS (m/z): Calcd for CnHi2N2O2S: 236.1; found 237.1 (M+H)., 30132-15-1

As the paragraph descriping shows that 30132-15-1 is playing an increasingly important role.

Reference：
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

30132-15-1, 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8; 3-(2-Fluorophenyl)-4-(2-(isopropylamino)benzo[d]thiazol-6-yl)-lH-pyrazol-5-oI; 1. Methyl 2-(2-aminobenzo[d]thiazol-6-yl)acetate[00175] A mixture of 2-(2-aminobenzo[d]thiazol-6-yl)acetic acid (95%, 10.0 g, 45.6 mmol), methanol (50 mL), 4 N HCl/l,4-dioxane (12.0 mL, 48.0 mmol) in 1,4- dioxane (30 mL) was heated at 750C for 9 hr and then concentrated under vacuum. The residue was suspended into water (50 mL) and basified to pH 9 with IN NaOH solution. The title compound (8.19 g, 81% yield) was collected as a pale solid by suction filtration and dried under vacuum at 5O0C.

30132-15-1, The synthetic route of 30132-15-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/16392; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30132-15-1,2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid,as a common compound, the synthetic route is as follows.

B. To prepare the intermediate methyl (2-amino-benzothiazol-6-yl)acetate, 2 mL concentrated H2SO4 was added dropwise to a solution of (2-amino-1,3-benzothiazol-6-yl)acetic acid (7.89 g, 37.9 mmol) in 200 mL methanol and the reaction mixture was heated at 50 C. for 90 minutes. After evaporation of most of the methanol, dichloromethane (150 mL) was added and the mixture was neutralized with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane. The organic extracts were combined, dried over MgSO4, and concentrated to give the product as a yellow solid (6.51 g, 77%). 1H NMR (DMSO-d6) delta 7.54 (s, 1H), 7.44 (br, 2H), 7.27 (d, 1H), 7.09 (d, 1H), 3.66 (s, 2H), 3.61 (s, 3H); LC-MS: ESI 223 (M+H)+., 30132-15-1

30132-15-1 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid 757163, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.; US2007/232604; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica