Category: 302964-20-1

Can You Really Do Chemisty Experiments About 302964-20-1

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 302964-20-1 is helpful to your research., Computed Properties of C9H11ClN2O3S

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.302964-20-1, Name is tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate, molecular formula is C9H11ClN2O3S. In a Article，once mentioned of 302964-20-1, Computed Properties of C9H11ClN2O3S

A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy. A series of substituted 2-(aminoheteroaryl)- thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 302964-20-1 is helpful to your research., Computed Properties of C9H11ClN2O3S

Reference：
Thiazole | C3H9081NS – PubChem,
Thiazole | chemical compound | Britannica

Simple exploration of 302964-20-1

If you are interested in 302964-20-1, you can contact me at any time and look forward to more communication.Synthetic Route of 302964-20-1

Synthetic Route of 302964-20-1, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.302964-20-1, Name is tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate, molecular formula is C9H11ClN2O3S. In a patent, introducing its new discovery.

The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.

If you are interested in 302964-20-1, you can contact me at any time and look forward to more communication.Synthetic Route of 302964-20-1

Reference£º
Thiazole | C3H9074NS – PubChem,
Thiazole | chemical compound | Britannica

Final Thoughts on Chemistry for 302964-20-1

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C9H11ClN2O3S. In my other articles, you can also check out more blogs about 302964-20-1

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 302964-20-1, Name is tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate, molecular formula is C9H11ClN2O3S. In a Patent£¬once mentioned of 302964-20-1, COA of Formula: C9H11ClN2O3S

The present invention provides an amide compound represented by the formula (1): wherein R1 and R2 independently represent a hydrogen atom or a methyl group; and Cy1 represents a C3-C6 cycloalkyl group, said compound having excellent plant disease controlling effect.

The present invention provides an amide compound represented by the formula (1): wherein R1 and R2 independently represent a hydrogen atom or a methyl group; and Cy1 represents a C3-C6 cycloalkyl group, said compound having excellent plant disease controlling effect.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C9H11ClN2O3S. In my other articles, you can also check out more blogs about 302964-20-1

Reference£º
Thiazole | C3H9075NS – PubChem,
Thiazole | chemical compound | Britannica

Analyzing the synthesis route of 302964-20-1

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

302964-20-1, tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Solution of tert-butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate (1.2 eq.) in dichloromethane (0.35 M) was added dropwise to a stirred solution of starting compound (5a-e) and triethylamine (2 eq.) in dichloromethane (0.075 M) at 0 C. The reaction mixture was stirred for 15 h at room temperature followed by removal of solvent under reduced pressure to obtain a crude product, which was purified by flash column chromatography using dichloromethane/methanol (19/1) or EtOAc as eluant.

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

Reference£º
Article; Trstenjak, Uro?; Ila?, Janez; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 302 – 313;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Some tips on 302964-20-1

As the paragraph descriping shows that 302964-20-1 is playing an increasingly important role.

302964-20-1, tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 10 mL of THF were added 0.8 g of 2- [(1,1- dimethylethoxy) carbonylamino] -5-carboxylic acid chloride, 0.27 g of (IS) -1-cyclohexylethylamine and 0.80 g of triethylamine, and the mixture was stirred at room temperature for 8 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with an aqueous saturated sodium bicarbonate and saturated brine successively, then dried over magnesium sulfate, and concentrated under reduced pressure. The resultant solid was washed with hexane to obtain 0.94 g of N- [ (IS) -1-cyclohexylethyl] -2- [ (1, 1- dimethylethoxy) carbonylamino] thiazole-5-carboxamide .N- [ (IS) -1-cyclohexylethyl] -2- [(1,1- dimethylethoxy) carbonylamino] thiazole-5-carboxamide1H-NMR (CDCl3) delta: 0.97-1.44 (8H, m) , 1.48-1.81 (15H, m) ,4.00-4.05 (IH, m) , 5.48 (IH, d, J = 8.9 Hz), 7.84 (IH, s), 10.49 (IH, br s) .

As the paragraph descriping shows that 302964-20-1 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66790; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 302964-20-1

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-20-1,tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate,as a common compound, the synthetic route is as follows.

Into a clean and dry 3L 4-neck round bottom flask connected to a mechanical stirrer,condenser and thermometer socket is charged with 2-tert-butoxycarbonylamino-thiazole-5-carboxylic acid chloride (4) crude (27.5 g) and dichloromethane (750 mL) under stirring. Cooled the reaction mass to 0-5 C and add 2-chloro-6-methylaniline (22.2 g) to the reaction mass at 0-5 C within 30-45 min period. Added DiPEA to the reaction mass at 0-5 C in 30-45 min period, raised the reaction mass temperature to 25-30 C and stirred the reaction mass at 25-30 C for 24 h. After TLC compliance distilled-off the solvent completely under plant vacuum at the temperature not crossing 50 C and Charge 2 N HCl (250 mL) to the reaction mass, Stirred for 15-30 min. Transferred the reaction mass into a Buchner funnel and flask kept under plant vacuum. The wet cake is washed with 500mL of water and dried the above-wet material in the dryer at temperature 60-65 C for 10-12 h. Purification: Into a clean and dry 3.0 L 4-neck round bottom flask connected to a mechanical stirrer, condenser, thermometer socket is charging with 2-tert-butoxy-carbonyl-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide crude, methanol and isopropyl ether under stirring at 25- 30 C. Raised the reaction mass temperature to 60-65 C and stirred the reaction mass at 60-65 C for 45-60 min. Cooled the reaction mass temperature to 25-30 C and transferred the reaction mass into a Buchner funnel and flask kept under plant vacuum. Washed the wet cake with 20.0 mL of methanol and dried the wet material in dryer at 60-65 C for 4-6 h to furnish 16.0 g of the title compound with purity above 95 %. Cream colour solid; Elemental analysis C16H18N3O3SClcalcd (found) %: C 52.24 (52.12), H 4.93 (5.05), N 11.42 (11.31),O 13.05 (13.25), S 8.72 (8.83). IR (KBr, numax, cm-1): 3423.42-3276.87, 3162.67, 2928.46, 1724.90, 1632.68-1566, 1522.80,775.21; 1H NMR (400 MHz, DMSO-d6): delta1.504 (s, 9H, -3CH3),2.225 (s, 3H, -CH3), 7.262-7.301 (t, 2H, ArH), 7.389-7.412(m, 1H, ArH), 8.204 (s, 1H, ArH), 10.017 (s, 1H, -NH), 11.847(s, 1H, -NH); 13C NMR (100 MHz, DMSO-d6): delta163.220, 159.74,152.91, 141.27, 139.02, 133.31, 132.57, 129.34, 128.64, 127.28,126.62, 82.33, 28.06, 18.45; ESI-MS (m/z): 368.21 (M+1),370.18 (M+3)

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

Reference£º
Article; Buchappa; Sagar Vijay Kumar; Durga Prasad; Aparna; Asian Journal of Chemistry; vol. 30; 7; (2018); p. 1621 – 1628;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica