Category: 302964-24-5

Brief introduction of 302964-24-5

302964-24-5 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 21911644, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

Add 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide A (4mmol, 1071mg), compound N1 (4mmol, 601mg) to the flask, add no 150ml of water toluene was installed on the water separator device, and the reaction was heated and refluxed for 24h. After the reaction was completed, toluene was distilled off under reduced pressure to obtain crude intermediate O1., 302964-24-5

302964-24-5 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 21911644, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Medical University; Zhao Jinwu; Xu Jingxiu; Zuo Changqing; (12 pag.)CN111039890; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Simple exploration of 302964-24-5

As the paragraph descriping shows that 302964-24-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

5mmol N,N-dimethylglycine,2mmol CuI,20mmol 4,6-dichloro-2-methylpyrimidine is soluble100 mL of N,N-dimethylformamide (DMF),22 mmol of N-hydroxyethylpiperazine was added with stirring.40mmol K3PO4, stir at room temperature for 40min,22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide was added with stirring.Passing N2 and reacting at 120 C for 6 h,The copper salt was dissolved in 50 mL of aqueous ammonia, and extracted with 50 mL of EtOAc (EtOAc).The crude product was added to 100 mL of an 80% aqueous ethanol solution, and stirred.2 g of activated carbon was added, refluxed for 30 min, filtered while hot, and the filtrate was recrystallized overnight, filtered, and the filter cake was washed with ice-cold 80% aqueous ethanol solution and dried.That is, 8.64 g of a white solid was obtained, the yield was 88.41%, and the purity was 99.92%.

As the paragraph descriping shows that 302964-24-5 is playing an increasingly important role.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Ren Qingwei; Zhang Qingdong; (12 pag.)CN109879869; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica