Category: 3034-22-8

Formula: C3H3BrN2SIn 2012 ,《Microwave-promoted synthesis and antimicrobial activity of 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives》 was published in Journal of Saudi Chemical Society. The article was written by Jagani, Chandresh L.; Sojitra, Natvar A.; Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.. The article contains the following contents:

The present paper described an optimized reaction condition for the microwave-promoted synthesis of newer 3-thiazole-substituted 2-styryl-4(3H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styrylbenzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation All the compounds were characterized by various spectroscopic techniques and anal. methods. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium, Bacillus subtilis, and Aspergillus niger. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Formula: C3H3BrN2S)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Formula: C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching》 were Leoni, Alberto; Frosini, Maria; Locatelli, Alessandra; Micucci, Matteo; Carotenuto, Claudio; Durante, Miriam; Cosconati, Sandro; Budriesi, Roberta. And the article was published in European Journal of Medicinal Chemistry in 2019. Reference of 5-Bromothiazol-2-amine The author mentioned the following in the article:

Synthesis, characterization and evaluation of neuroprotective effects of a focused library of 4-imidazo[2,1-b]thiazole-1,4-dihydropyridines I [R = 2-FC6H4, 4-ClC6H4, 4-O2NC6H4, etc.; R1 = Me, Et, H2C=CHCH2; R2 = H, Me, Et, F, Cl, Br; R3 = H, Me]. Furthermore, the dihydropyridines were subjected to functional in vitro assays in cardiac tissues and vascular smooth muscle to determine their possible selectivity in counteracting the effects of neurodegeneration. In particular the strategy adopted for designing the compounds involved the imidazo[2,1-b]thiazole nucleus. The observed properties showed that substituents at C2 and C6 of the bicyclic scaffold were able to influence the cardiovascular parameters and the neuroprotective activity. In comparison to nifedipine, a set of derivatives such as compound I [R = CF3; R1 = Me; R2 = Me; R3 = H], showed a neuroprotective profile of particular interest. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2011,Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah; Smith, Jeff; Scudiero, Dominic; Kondapaka, Sudhir; Shoemaker, Robert H. published 《Imidazo[2,1-b]thiazole guanidinylhydrazones as RSK2 inhibitors》.European Journal of Medicinal Chemistry published the findings.Product Details of 3034-22-8 The information in the text is summarized as follows:

The activity of a series of imidazo[2,1-b]thiazole guanidinylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells. In the part of experimental materials, we found many familiar compounds, such as 5-Bromothiazol-2-amine(cas: 3034-22-8Product Details of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2010,Wang, Yingcai; Jiao, Xianyun; Kayser, Frank; Liu, Jiwen; Wang, Zhongyu; Wanska, Malgorzata; Greenberg, Joanne; Weiszmann, Jennifer; Ge, Hongfei; Tian, Hui; Wong, Simon; Schwandner, Ralf; Lee, Taeweon; Li, Yang published 《The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 5-Bromothiazol-2-amine The information in the text is summarized as follows:

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacol. tools for exploring the potential function of FFA2 in various disease conditions. In addition to this study using 5-Bromothiazol-2-amine, there are many other studies that have used 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine) was used in this study.

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution》 were Chenna Reddy, M. L.; Patil, Vineetkumar B.; Nawaz Khan, Fazlur Rahman; Saravanan, Vadivelu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Application of 3034-22-8 The author mentioned the following in the article:

A new method has been developed for the synthesis of imidazo[1,2-a]pyridines I (R = H, Me, CN, Br, OMe, etc.; R1 = R2 = H; R1R2 = CH=CH-CH=CH; RR1 = CH=CH-CH=CH; X = CH2, O, S; n = 0, 1, 2), imidazo[2,1-b]thiazoles II (R3 = H, Me, Br, Cl, COOMe; X = CH2, O, S; n = 0, 1, 2), and benzo[d]imidazo[2,1-b]thiazoles III (R4 = H, OMe, Br, F, CF3) attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones IV to afford the desired products in good yields. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2014,Li, Ningning; Xu, Yintong; Xia, Qiang; Bai, Cuigai; Wang, Taiyi; Wang, Lei; He, Dingdi; Xie, Nannan; Li, Lixin; Wang, Jing; Zhou, Hong-Gang; Xu, Feng; Yang, Cheng; Zhang, Quan; Yin, Zheng; Guo, Yu; Chen, Yue published 《Simplified captopril analogues as NDM-1 inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Synthetic Route of C3H3BrN2S The information in the text is summarized as follows:

Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9 μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, the authors synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors to identify the pharmacophore for NDM-1 inhibition. The authors found that the lead compound(R)-N-benzyl-3-mercapto-2-methylpropanamide had an IC50 value of 1.0 μM. Further structure simplification provided compounds 3-mercapto-2-methylpropan-1-ol and 2,3-dimercaptopropan-1-ol, which had IC50 values of 15 and 10 μM, resp. As 2,3-dimercaptopropan-1-ol is a clin. used antidote for metal poisoning, it has great potential to be repurposed to treat bacterial infections.5-Bromothiazol-2-amine(cas: 3034-22-8Synthetic Route of C3H3BrN2S) was used in this study.

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2005,Kitagawa, Tokujiro; Asada, Makoto published 《Preparation and root growth-inhibitory activity of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl)propanamides》.Chemical & Pharmaceutical Bulletin published the findings.HPLC of Formula: 3034-22-8 The information in the text is summarized as follows:

A series of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl)propanamides, e.g., I, was prepared through the reaction of chloroacetyl chloride with N-substituted 2-amino-3-(furan-2-yl)propanamides, which were obtained by condensation of 2-(tert-butoxycarbonylamido)-3-(furan-2-yl)propanoic acid (Boc-furylalanine) with amines, followed by hydrolysis of the resultant N-substituted Boc-furylalanine acid amides in the presence of HCl/dioxane. The biol. activity of the prepared compounds as root growth inhibitors was examined by germination assay using rape seed. At the concentration of 5.0 × 10-5 M, the most active compound, 2-(2-chloroacetamido)-N-(2,6-diethylphenyl)-3-(furan-2-yl)propanamide (I), showed potent root growth-inhibitory activity of 76% towards rape seedlings. After reading the article, we found that the author used 5-Bromothiazol-2-amine(cas: 3034-22-8HPLC of Formula: 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2003,Razus, Alexandru C.; Birzan, Liviu; Nae, Stefania; Surugiu, Mirela Nina; Cimpeanu, Valentin published 《Azulene-1-azo-2′-thiazoles. Synthesis and properties》.Journal of Heterocyclic Chemistry published the findings.Reference of 5-Bromothiazol-2-amine The information in the text is summarized as follows:

Several derivatives belonging to a new compound class, namely azulene-1-azo-2′-thiazoles, were prepared by the diazotization of 2-aminothiazoles in the presence of HNO3/H3PO4 followed by the coupling of diazonium salts with azulenes in buffered medium. The reactions proved to be general for this class, with the yields being considerably influenced by the thiazole substituents. For the first time a N-oxide of an amino-substituted five-membered nitrogen heterocycle was diazotized and coupled. The structure of the obtained azo dyes was assigned and their physico-chem. properties were discussed. The new azulene azo derivatives exhibit a strong bathochromic shift in their UV-visible spectra due to the intense push-pull effect of the azulene aromatic system and the intrinsic properties of the thiazole moiety. In the part of experimental materials, we found many familiar compounds, such as 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2001,Kitagawa, Tokujiro; Akiyama, Naohiro; Masai, Katsunori published 《Preparation and root growth-modulatory activity of N-substituted 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides》.Chemical & Pharmaceutical Bulletin published the findings.Category: thiazole The information in the text is summarized as follows:

N-Substituted 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides were synthesized through the reaction of amines with 2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanoic acid, which was prepared via condensation of 2-(bromomethyl)furan with di-Et acetamidomalonate, followed by partial hydrolysis of the resultant di-Et ester in the presence of barium hydroxide. However, bulky amines such as tert-butylamine or 2-trifluoromethylaniline did not afford the corresponding diamides. The biol. activity of the prepared diamides as root growth modulators was examined by germination assay using rape and leek seeds. N-(5-Bromo-2-thiazolyl)- and N-(4-chloro-2-benzothiazolyl)-2-acetylamino-2-ethoxycarbonyl-3-(2-furyl)propanamides both potently inhibited the root growth of rape seedlings, but were less effective in the case of leek seeds. The herbicide 2,4-dichlorophenoxyacetic acid completely inhibited root growth in both cases. The results came from multiple reactions, including the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Category: thiazole)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2013,Savanor, Prasanna M.; Jathi, Keshavayya; Bhat, Subramanya K.; Tantry, Rajesh N. published 《Synthesis, characterization and solvatochromic studies of 3-{2-(5-bromothiazol-2-yl)diazenyl}-4-bromopyridine-2,6-diamine》.Research Journal of Chemical Sciences published the findings.Formula: C3H3BrN2S The information in the text is summarized as follows:

The 3-{2-(5-bromothiazol-2-yl)diazenyl}-4-bromopyridine-2,6-diamine was synthesized by carrying the diazotization of 5-bromothiazol-2-amine in coupling with 4-bromopyridine-2,6-diamine as a coupling component to yield a azo dye. The structure of the dye was confirmed by UV-visible spectrophotometry, FTIR, LC-MS, 1H and 13C NMR spectroscopic methods. The change in the absorption maxima of the synthesized compound in different solvents were determined, the solvatochromic property of the dye showed a medium red shift in different solvents and showed the moderate solvent dependency over the bathochromic shift. The experimental part of the paper was very detailed, including the reaction process of 5-Bromothiazol-2-amine(cas: 3034-22-8Formula: C3H3BrN2S)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica