Category: 3034-55-7

3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of compound fert-butyl 4-(4-((4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate (1 equiv), K3PO4 (2 equiv), 5-bromothiazole (1 equiv) and Pd(dppf)Cl2 (0.1 equiv) in dioxane water was stirred at 100C under N2 for 16 hrs. The reaction mixture was cooled down to room temperature and quenched by the addition of water, extracted with EtOAc. The combined organics were dried with Na2S04, filtered and solvent removed under reduced pressure. The residue was purified by silica gel chromatography to afford tert-butyl 4-(4-((4-(thiazol-5- yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate.

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Patent; KADMON CORPORATION, LLC; SKUCAS, Eduardas; LIU, Kevin, G.; KIM, Ji-In; POYUROVSKY, Masha, V.; MO, Rigen; (345 pag.)WO2019/45824; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

Svnthesis 32 2-Chlor -3-thiazol-5-yl-pyridine To a degassed suspension of 5-bromothiazole (3 mmol, 0.5 g) and 2-chloro-3-(4, 4,5,5- tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-pyridine (3 mmol, 0.73 g) in 1 ,4-dioxane (14 mL) water (6 mL) was added potassium carbonate (9 mmol, 1.25 g) and bis(triphenylphenylphospine) palladium (II) dichloride (0.15 mmol, 0.10 g). The mixture was heated in a microwave reactor at 120 C for 15 minutes. The mixture was purified by flash chromatography using a gradient elution of 0-100% ethyl acetate/cyclohexane. The solvent was removed by evaporation under reduced pressure to yield the title compound as a low-melting point colourless solid. Yield: 0.42 g, 72%. LCMS, analytical method 1 , TR= 3.37 mins, 95%, M+H=197. H NMR (300 MHz, CDCIs) delta: 8.92 (1 H, s), 8.42 (1 H, d), 8.15 (1 H, s), 7.85 (1 H, d), 7.35 (1 H, m)., 3034-55-7

The synthetic route of 3034-55-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHARLES, Mark David; BROOKFIELD, Joanna Lola; EKWURU, Chukuemeka Tennyson; STOCKLEY, Martin Lee; WO2015/25172; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromothiazole (1.55 g, 9.0 mmol), piperidine (2.7 mL, 27.0 mmol), sodium tert-butoxide (1.78 g, 18.0 mmol), Rh(cod)2BF4 (73 mg, 2.0 mol %), 1,3-diisopropylimidazolium chloride (70 mg, 4.0 mol %) and 1,2-dimethoxyethane (9 mL) were mixed under argon atmosphere. The reaction mixture was vigorously stirred at 80 C overnight, then it was cooled down to room temperature and diluted with AcOEt. The crude reaction was filtered through a pad of silica gel, the organic solvents were evaporated and the residue was purified by flash chromatography on silica gel using as eluent CH2Cl2/AcOEt 10:0.5, then 10:1, to afford a slightly yellow oil (1.40 g; 92%). Found: C 57.49, H 6.92, N 16.48. C8H12N2S requires C 57.11, H 7.19, N 16.65%. IR (Nujol, cm-1): 1651 (CN), 1558 (CC), 1539 (CC). 1H NMR (400 MHz, CDCl3): delta 8.16 (s, 1H), 7.01 (s, 1H), 3.15-3.05 (m, 4H), 1.75-1.68 (m, 4H), 1.60-1.53 (m, 2H). 13C NMR (75 MHz, CDCl3): delta 156.0, 140.5, 122.3, 53.5, 25.1, 23.5. HRMS (ESI+): found 169.0789 [M+H]+. C8H13N2S requires 169.0794., 3034-55-7

As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Article; Galan, Elena; Andreu, Raquel; Garin, Javier; Mosteo, Laura; Orduna, Jesus; Villacampa, Belen; Diosdado, Beatriz E.; Tetrahedron; vol. 68; 32; (2012); p. 6427 – 6437;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromothiazole (200 mg, 1.2 mmol), (2-nitrophenyl)boronic acid (306 mg, 1.8 mmol), Na2CO3 (259 mg, 2.4 mmol) and Pd(PPh3)4(141 mg, 0.1 mmol) in DMA (5 mL) was degassed with nitrogen, heated to 150 C. and stirred for 2 hours under nitrogen atmosphere and microwave. The reaction was cooled to r.t, filtered and concentrated in vacuo. The residue was diluted with water, extracted with EA. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to give 5-(2-nitrophenyl)thiazole (130 mg, 52% yield) as a yellow solid. LC/MS (ESI, m/z): [M+1]+=207.2

3034-55-7, 3034-55-7 5-Bromothiazole 546059, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica