Category: 3034-56-8

Bilodeau, Mark T.; Rodman, Leonard D.; McGaughey, Georgia B.; Coll, Kathleen E.; Koester, Timothy J.; Hoffman, William F.; Hungate, Randall W.; Kendall, Richard L.; McFall, Rosemary C.; Rickert, Keith W.; Rutledge, Ruth Z.; Thomas, Kenneth A. published the artcile< The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase>, Formula: C3HBrClNS, the main research area is thiazolyl pyridinamine preparation KDR kinase active site mol modeling; pyridinamine thiazolyl preparation KDR kinase ligand.

An azo-dye lead was modified to a N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. The two lead compounds were N-butyl-N,3-dimethyl-4-[(5-nitro-2-thiazolyl)azo]benzenamine and N-(5-phenyl-2-thiazolyl)benzamide. This class has been found to be potent, selective, and of low mol. weight Mol. modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme. A binding mode was proposed for the lead compound N-(5-phenyl-2-thiazolyl)-2-pyridinamine (I) in the KDR kinase active site.

Bioorganic & Medicinal Chemistry Letters published new progress about Chemical library. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Formula: C3HBrClNS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sharma, G. M.; Parshad, Baldev; Narang, K. S. published the artcile< Thiazole derivatives. VI. Synthesis of 2-chloro-5-bromothiazoles>, Safety of 5-Bromo-2-chlorothiazole, the main research area is chloro bromo thiazoles; bromo chloro thiazoles; thiazoles chloro bromo.

The title compounds (I) were prepared as follows: ω – thiocyano ketones, NCSCH2C:OR were dissolved in CCl4 or C6H6, depending upon their solubilities, equivalent amounts C5H5N added, and an equivalent amount Br in the same solvent added dropwise at 40-50°. The solvent was distilled in vacuo, the residue treated with H2O to remove C5H5N.HBr, the ω-bromo-ω-thiocyano ketones RCOCH2SCN (II) were collected, washed, and crystallized from EtOH, solutions of II in dry ether saturated with dry HCl gas at 0°, the mixtures kept 12 hrs. at room temperature, the ether was decanted, and the residue purified either by distillation or crystallization to afford 2-chloro-5-bromothiazoles (III). The following II and III were prepared [R, m.p. II, % yield II, m.p. (or b.p./mm.) III, and % yield given]: Ph, 74°, 55.5, (155°/7), 67.6; p-MeC6H4, 94°, 54.5, 64°, 66.03; p-MeOC6H4, 81°, 86.2, 96°, 69.8; p-ClC6H4, 136°, 67.8, 85°, 70.9; p-BrC6H4, 120°, 71.6, 108°, 66.7.

Indian Journal of Chemistry published new progress about Cyclization. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Safety of 5-Bromo-2-chlorothiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Parkanyi, Cyril; Vernin, Gaston; Zamkostian, Rose Marie; Metzger, Jacques published the artcile< Photolysis of bromothiazoles in hydrogen-donating solvents. A theoretical study and physical properties of bromothiazoles>, Product Details of C3HBrClNS, the main research area is photodebromination bromothiazole mechanism; NMR proton bromothiazole; UV bromothiazole fluorescence phosphorescence; mass spectra bromothiazole.

A PPP treatment and UV, fluorescence, phosphorescence, and 1H NMR indicate that the photodebromination of bromothiazoles (to give thiazole and isothiazole) in H-donating solvents involves C-Br bond homolysis in the first excited singlet state to give a thiazolyl radical which abstracts H. In the presence of amines the mechanism involves an electron transfer to form an exciplex in which the bromothiazole anion radical loses Br- to give the thiazolyl radical. The photodebromination reactivity order, 2-bromothiazole > 5-bromothiazole ≫ 4-bromothiazole, reflects the ground state C-Br bond strengths; this is supported by the mass spectra of the bromothiazoles.

Heterocycles published new progress about Electronic excitation. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Product Details of C3HBrClNS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Volgraf, Matthew; Sellers, Benjamin D.; Jiang, Yu; Wu, Guosheng; Ly, Cuong Q.; Villemure, Elisia; Pastor, Richard M.; Yuen, Po-wai; Lu, Aijun; Luo, Xifeng; Liu, Mingcui; Zhang, Shun; Sun, Liang; Fu, Yuhong; Lupardus, Patrick J.; Wallweber, Heidi J. A.; Liederer, Bianca M.; Deshmukh, Gauri; Plise, Emile; Tay, Suzanne; Reynen, Paul; Herrington, James; Gustafson, Amy; Liu, Yichin; Dirksen, Akim; Dietz, Matthias G. A.; Liu, Yanzhou; Wang, Tzu-Ming; Hanson, Jesse E.; Hackos, David; Scearce-Levie, Kimberly; Schwarz, Jacob B. published the artcile< Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design>, Synthetic Route of 3034-56-8, the main research area is NMDA receptor allosteric modulator PAM deactivation structure design; crystal structure.

The N-methyl-D-aspartate receptor (NMDAR) is a Na+ and Ca2+ permeable ionotropic glutamate receptor that is activated by the coagonists glycine and glutamate. NMDARs are critical to synaptic signaling and plasticity, and their dysfunction has been implicated in a number of neurol. disorders, including schizophrenia, depression, and Alzheimer’s disease. Herein we describe the discovery of potent GluN2A-selective NMDAR pos. allosteric modulators (PAMs) starting from a high-throughput screening hit. Using structure-based design, we sought to increase potency at the GluN2A subtype, while improving selectivity against related α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). The structure-activity relationship of channel deactivation kinetics was studied using a combination of electrophysiol. and protein crystallog. Effective incorporation of these strategies resulted in the discovery of GNE-0723 (46), a highly potent and brain penetrant GluN2A-selective NMDAR PAM suitable for in vivo characterization.

Journal of Medicinal Chemistry published new progress about Crystal structure. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Synthetic Route of 3034-56-8.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lund, Henning published the artcile< Electroorganic preparations. XVI. Polarography and reduction of quinazoline>, Formula: C3HBrClNS, the main research area is .

The polarographic reduction of quinazoline (I) was observed throughout the pH range 0-12 and in more acid media (acidity function H+ to -2); 2 waves were observed. For the 1st wave the limiting current is diffusion controlled at pH 5 but is kinetically controlled at pH 1. The abnormal pH dependence of the limiting current can be explained by hydration of the protonated I nucleus if it is assumed that only the normal cation and not the hydrated cation is polarographically reducible. The rate constant of the dehydration was determined from polarographic data, and the dehydration was found to be specific acid catalyzed. The second wave of I is a reduction of the 3,4-dihydroquinazoline (II) formed in the first reduction at low concentrations of I. II was reduced in borate buffer to 1,2,3,4-tetrahydroquinazoline. I yields on controlled potential reduction both in acid and alk. solution a dimerized product, which probably is dimerized at C-4. The product can be reoxidized to I with hexacyanoferrate(III) in alk. solution

Acta Chemica Scandinavica published new progress about 3034-56-8. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Formula: C3HBrClNS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Boga, C.; Del Vecchio, E.; Forlani, L.; Todesco, P. E. published the artcile< Tetrahalomethanes: simple reagents for the synthesis of monohalogenated and mixed dihalogenated aromatic heterocycles via metal-halogen exchange from lithium compounds>, Quality Control of 3034-56-8, the main research area is halogenation aromatic heterocycle; lithium halogen exchange aromatic heterocycle.

Tetrabromo- or tetrachloromethane and 2-lithio derivatives of aromatic heterocycles rapidly produce the corresponding 2-bromo or 2-chloro derivatives in high yields through a metal-halogen exchange mechanism. This kind of reaction was also used to obtain, in good yields, 5-bromo-2-chlorothiazole and 5-bromo-2-chloro-N-methylimidazole.

Journal of Organometallic Chemistry published new progress about Halogenation. 3034-56-8 belongs to class thiazole, and the molecular formula is C3HBrClNS, Quality Control of 3034-56-8.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica