Category: 303994-99-2

TBHP/AIBN-Mediated Synthesis of 2-Amino-thiazoles from Active Methylene Ketones and Thiourea under Metal-free Conditions was written by Sun, Jiyun;Ge, Huaibin;Zhen, Xiaohua;An, Xuechan;Zhang, Guangtao;Zhang-Negrerie, Daisy;Du, Yunfei;Zhao, Kang. And the article was included in Tetrahedron in 2018.Product Details of 303994-99-2 The following contents are mentioned in the article:

A new oxidative system of tert-Bu hydroperoxide (TBHP)/azodiisobutyronitrile (AIBN) was used for the first time for a convenient, metal-free synthesis of substituted 2-aminothiazoles from active methylene ketone derivatives and thiourea. The reaction was postulated to proceed via an oxidative cyclization initiated by a radical process and followed by a condensation reaction. This study involved multiple reactions and reactants, such as 2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2Product Details of 303994-99-2).

2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 303994-99-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis was written by Francisco, Gerardo D.;Li, Zhong;Albright, J. Donald;Eudy, Nancy H.;Katz, Alan H.;Petersen, Peter J.;Labthavikul, Pornpen;Singh, Guy;Yang, Youjun;Rasmussen, Beth A.;Lin, Yang-I.;Mansour, Tarek S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Product Details of 303994-99-2 The following contents are mentioned in the article:

Over 50 Ph thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-pos. bacteria including MRSA, VRE and PRSP. (3,4-Difluorophenyl)(5-cyanothiazolyl)urea with clog P of 2.64 demonstrated antibacterial activity against both gram-pos. and gram-neg. bacteria. The activity of these (phenyl)(thiazolyl)urea and (thiazolyl)carbamate derivatives was also compared to 3-[[[(3,4-dichlorophenyl)amino]carbonyl]amino]-2-thiophenecarboxylic acid Me ester, 5-[[[(3,4-dichlorophenyl)amino]carbonyl]amino]-1-methyl-1H-pyrazole-4-carboxylic acid Me ester, N-(3,4-dichlorophenyl)-N‘-(2-pyridinyl)urea, and some other compounds Antibacterial activity was screened against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococus (VRE), penicillin-resistant Streptococcus pneumoniae (PRSP). Mol. modeling studies were carried out to explore binding preferences within this compound series in the MurB structure. This study involved multiple reactions and reactants, such as 2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2Product Details of 303994-99-2).

2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 303994-99-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica