Category: 317318-97-1

Related Products of 317318-97-1, An article , which mentions 317318-97-1, molecular formula is C12H9ClF3NS. The compound – 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole played an important role in people’s production and life.

Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

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Reference：
Thiazole | C3H6009NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 317318-97-1. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole. In a document type is Article, introducing its new discovery.

The most potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

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Reference：
Thiazole | C3H5998NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent，once mentioned of 317318-97-1, Recommanded Product: 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole. In my other articles, you can also check out more blogs about 317318-97-1

Reference：
Thiazole | C3H5988NS – PubChem,
Thiazole | chemical compound | Britannica

317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 317318-97-1, Quality Control of: 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

The invention relates to 4-oxy-N-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides and to their physiologically acceptable salts and physiologically functional derivatives showing PPARalpha, PPARdelta and PPARgamma agonist activity. What is described are compounds of the formula (I), in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole. In my other articles, you can also check out more blogs about 317318-97-1

Reference：
Thiazole | C3H6000NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent，once mentioned of 317318-97-1, COA of Formula: C12H9ClF3NS

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.COA of Formula: C12H9ClF3NS, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 317318-97-1, in my other articles.

Reference：
Thiazole | C3H5986NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 317318-97-1, C12H9ClF3NS. A document type is Article, introducing its new discovery., name: 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily. Herein, we describe an efficient synthesis of a novel isosteric selenium analog of the highly specific PPARbeta/delta ligand 2-methyl-4-((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)-meth ylsulfanyl)phenoxy-acetic acid (GW501516; 1). The study examined the efficiency of the novel selenium analog 2-methyl-4-((4-methyl-2-(4-trifluoromethylphenyl)-1,3-selenazol-5-yl)-me thylsulfanyl)phenoxy-acetic acid (2) to activate PPARbeta/delta and the effect of ligand activation of PPARbeta/delta on cell proliferation and target gene expression in human HaCaT keratinocytes. The results showed that similar to GW501516, the Se-analog 2 increased expression of the known PPARbeta/delta target gene angiopoietin-like protein 4 (ANGPTL4); the compound 2 was comparable in efficacy as compared to GW501516. Consistent with a large body of evidence, the Se-analog inhibited cell proliferation in HaCaT keratinocytes similar to that observed with GW501516. In summary, the novel Se-analog 2 has been developed as a potent PPARbeta/delta ligand that may possess additional anti-cancer properties of selenium.

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Reference：
Thiazole | C3H6006NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 317318-97-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent，once mentioned of 317318-97-1

The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methylor ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 317318-97-1 is helpful to your research., Related Products of 317318-97-1

Reference：
Thiazole | C3H5992NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 317318-97-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

Optimization of GPR40 agonists for type 2 diabetes

GPR40 (FFA1 and FFAR1) has gained significant interest as a target for the treatment of type 2 diabetes. TAK-875 (1), a GPR40 agonist, lowered hemoglobin A1c (HbA1c) and lowered both postprandial and fasting blood glucose levels in type 2 diabetic patients in phase II clinical trials. We optimized phenylpropanoic acid derivatives as GPR40 agonists and identified AMG 837 (2) as a clinical candidate. Here we report our efforts in searching for structurally distinct back-ups for AMG 837. These efforts led to the identification of more polar GPR40 agonists, such as AM-4668 (10), that have improved potency, excellent pharmacokinetic properties across species, and minimum central nervous system (CNS) penetration.

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Reference：
Thiazole | C3H6007NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent，once mentioned of 317318-97-1, COA of Formula: C12H9ClF3NS

Aniline derivatives, their manufacture and use as pharmaceuticals

This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; Ris hydrogen or C1-7-alkyl; Rand Rindependently from each other are selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkoxy; R, R, R, and Rindependently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy, C1-7-alkyl-C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl and cyano; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C12H9ClF3NS, you can also check out more blogs about317318-97-1

Reference：
Thiazole | C3H5984NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent£¬once mentioned of 317318-97-1, SDS of cas: 317318-97-1

The present invention provides novel benzimidazole compounds of the formula (I): wherein each symbol is as defined in the specification, salts thereof and prodrugs thereof, which are useful in treating, for example, the diseases curable through decrease in blood sugar level.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.SDS of cas: 317318-97-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 317318-97-1, in my other articles.

Reference£º
Thiazole | C3H5993NS – PubChem,
Thiazole | chemical compound | Britannica