Category: 31784-71-1

Prasad, V. S. R. published the artcileVersatile synthesis of 2-aryl[1,2,4]triazolo[3′,2′:2,3]thiazolo[5,4-b]pyridines, Safety of 5-Chlorothiazolo[5,4-b]pyridin-2-amine, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1991), 30B(5), 517-18, database is CAplus.

The reaction of aminothiazolopyridines I (R = Cl, OMe) with RC₆H₄CN ( R = H, 2-, 4-Me, 2-, 4-Cl, 4-NO₂) in the presence of AlCl₃ gave arylamidines II, which on dehydrogenation-cyclization with Pb(OAc)₄ in benzene gave triazolothiazolopyridines III.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Safety of 5-Chlorothiazolo[5,4-b]pyridin-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Prasad, V. S. R. published the artcileFormation and pyrolysis of 1-(2-thiazolo[5,4-b]pyridyl)-5-aryltetrazoles, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine, the publication is Synthetic Communications (1990), 20(13), 1983-8, database is CAplus.

The reaction of 2-amino-5-chlorothiazolo[5,4-b]pyridine or 2-amino-5-methoxythiazolo[5,4-b]pyridine with RC₆H₄COCl (R = H, 4-Me, 2-Cl, 4-Cl, 4-MeO) gave the resp. amides which were treated with PCl₅ and then with NaN₃ to give (thiazolopyridyl)phenyltetrazole derivatives The latter were pyrolyzed to give 2-aryl-1,2,4-triazolo[3′,2′:2,3]thiazolo[5,4-b]pyridines I (same R), presumably via a nitrene intermediate.

Synthetic Communications published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sambaiah, T. published the artcileSynthesis of N-[2H-[1,2,4]thiadiazolo[3′,2′:2,3]thiazolo[5,4-b]pyridin-2-ylidene]aroylamines, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine, the publication is Synthetic Communications (1990), 20(3), 355-64, database is CAplus.

The reaction of aminothiazolopyridines I (R = MeO, Cl) with R¹C₆H₄CONCS (R¹ = H, 3-Me, 4-Me, 4-MeO, 2-Cl, 4-Cl) in acetone gave (thiazolopyridinyl)thioureas II. Cyclization of II in the presence of PCl₅ in POCl₃ gave thiadiazolothiazolopyridinylidene)aroylamines III.

Synthetic Communications published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Rao, Ashwin U. published the artcileSynthesis and structure-activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridines as H₃ receptor antagonists, SDS of cas: 31784-71-1, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6176-6180, database is CAplus and MEDLINE.

A series of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridines I (X = N, Y = CH; X = CH, Y = N; R = H, H₂N, CN, Cl, MeCONH, 4-NCC₆H₄, 2-fluoro-3-pyridyl, 5-pyrimidyl, etc.) was synthesized and evaluated as a new lead of non-imidazole histamine H₃ receptor antagonists. Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in vitro potency and decrease hERG activity. The structure-activity relationships for these new thiazolopyridine antagonists are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, SDS of cas: 31784-71-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hirose, Masaaki published the artcileDesign and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives, Quality Control of 31784-71-1, the publication is Bioorganic & Medicinal Chemistry (2012), 20(18), 5600-5615, database is CAplus and MEDLINE.

Our aim was to discover RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors that possess strong activity and sufficient oral absorption, and thus, we selected a 5-amino-linked thiazolo[5,4-d]pyrimidine derivative as the lead compound because of its potential kinase inhibitory activities and its desired solubility The novel tertiary 1-cyano-1-methylethoxy substituent was designed to occupy the hydrophobic region of ‘back pocket’ of BRAF on the basis of the X-ray co-crystal structure data of BRAF. In addition, we found that N-methylation of the amine linker could control the twisted mol. conformation leading to improved solubility These approaches produced N-Me thiazolo[5,4-b]pyridine-5-amine derivative 5 (I). To maximize the in vivo efficacy, we attempted salt formation of 5. Our result indicated that the besylate monohydrate salt form (5c) showed significant improvement of both solubility and oral absorption. Owing to the improved physicochem. properties, compound 5c demonstrated regressive antitumor efficacy in a HT-29 xenograft model.

Bioorganic & Medicinal Chemistry published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Quality Control of 31784-71-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Belaidi, Salah published the artcileElectronic structure and physico-chemical property relationship for thiazole derivatives, Synthetic Route of 31784-71-1, the publication is Asian Journal of Chemistry (2013), 25(16), 9241-9245, database is CAplus.

Electronic structure, effect of the substitution and structure physico-chem. property relationship for thiazole derivatives, has been studied by ab initio and DFT method. In the present work, the calculated values, i.e., net charges, bond lengths, dipole moments, electron-affinities, heats of formation and QSPR properties, are reported and discussed in terms of the reactivity of thiazole derivatives

Asian Journal of Chemistry published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Synthetic Route of 31784-71-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Belaidi, Salah published the artcileElectronic structure and physico-chemical property relationship for thiazole derivatives, Synthetic Route of 31784-71-1, the publication is Asian Journal of Chemistry (2013), 25(16), 9241-9245, database is CAplus.

Electronic structure, effect of the substitution and structure physico-chem. property relationship for thiazole derivatives, has been studied by ab initio and DFT method. In the present work, the calculated values, i.e., net charges, bond lengths, dipole moments, electron-affinities, heats of formation and QSPR properties, are reported and discussed in terms of the reactivity of thiazole derivatives

Asian Journal of Chemistry published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Synthetic Route of 31784-71-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tsuruoka, Akihiko published the artcileSynthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine, the publication is Chemical & Pharmaceutical Bulletin (1998), 46(4), 623-630, database is CAplus and MEDLINE.

A series of novel thiazole-containing triazole antifungals, I (R₁ = Ph, 4-FC₆H₄, Q, etc.) and II (X = CH, N, Y = Cl, F, CSNH₂, etc.), was synthesized and evaluated for antifungal activity against a variety of clin. isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1 ,2,4-triazol-1-yl)-2-butanol (ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.

Chemical & Pharmaceutical Bulletin published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C9H21NO3, Recommanded Product: 5-Chlorothiazolo[5,4-b]pyridin-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica