Category: 31785-05-4

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 127; 5-Amino-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide; The title compound was prepared as described in scheme 6. A) A solution of 5-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (prepared as described in example 105, step A) (0.10 g, 0.54 mmol) in THF (2.5 ml) was treated with dimethylaminopyridine (DMAP) and di-tert-butyl dicarbonate (Boc2O). The mixture was irradiated in a microwave oven at 100 C. for 10 min, then the solvent was evaporated. The residue was purified by flash chromatography (heptane/ethyl acetate) yielding 2-tert-butoxycarbonylamino-5-methyl-thiophene-3-carboxylic acid ethyl ester (0.11 g, 70%) as a yellow oil; B) 5-Amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.40 g, 2.15 mmol) was dissolved in 20 ml dry THF. Di-tert.-butyl dicarbonate (0.526 g, 4.41 mmol) and 4-(N,N-dimethylamino)pyridine (0.036 g, 0.3 mmol) were added and the reaction mixture was stirred at 70 C. overnight. The solvent was evaporated, the residue taken up in 20 mL saturated sodium bicarbonate solution and extracted three times with ethyl acetate (30 mL each). The organic phases were pooled, dried with sodium sulfate and evaporated. The crude product was flash-chromatographed on silica gel with heptane/ethyl acetate 100:0?0:100 gradient to yield 5-tert-butoxycarbonylamino-2-methyl-thiazole-4-carboxylic acid ethyl ester as a light yellow solid (0.553 g, 90%)

31785-05-4, 31785-05-4 Ethyl 5-amino-2-methylthiazole-4-carboxylate 13329095, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

B) A-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.15 g, 0.806 mmol), cyclopropancarboxaldehyde (0.23 g, 3.29 mmol) was treated with cyclopropanecarboxaldehyde (0.230 g, 3.22 mmol) and tetraisopropyl-orthotitanate (0.916 g, 3.22 mmol) and stirred at room temperature overnight. Ethanol (5 mL) and sodium cyanoborohydride (0.213 g, 3.22 mmol) were added and the reaction mixture was stirred for 5 h. Water (0.5 mL) was added to the reaction mixture and the solvent was evaporated. The residue was purified by flash chromatography on silica gel with ethyl acetate/methanol 100:0?90:10 gradient to yield 5-((cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid isopropyl ester (0.170 g, 83%) as a yellow oil

31785-05-4, The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

ethyl 2-methyl-5- (f [ (trichloroacetyl) aminolcarbonyllamino)-1, 3-thiazole-4-carboxylate.; To a stirred solution of ethyl 5-amino-2-methyl-1, 3-thiazole-4-carboxylate (1 equiv) in anhydrous THF (10 mL) was added trichloroacetyl isocyanate (1 eq) slowly over a period of 5 min. After the addition was complete, a precipitate formed and the reaction stirred for an additional lh. The desired product was obtained by filtration (99% yield) as a yellow solid. The product was used in the next step without any further purification. LC/MS (ES, M+H=374)., 31785-05-4

The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/66163; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica