Category: 31825-95-3

Nicolaou, K. C.; Leung, Gulice Y. C.; Dethe, Dattatraya H.; Guduru, Ramakrishna; Sun, Ya-Ping; Lim, Chek Shik; Chen, David Y.-K. published the artcile< Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues>, Product Details of C5H6N2OS, the main research area is palmerolide A analog preparation antitumor.

Mol. design and chem. synthesis of several palmerolide A analogs allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From several analogs synthesized and tested, compounds I (with a Ph substituent on the side chain) and II (lacking the C-7 hydroxyl group) were the most interesting, exhibiting approx. a 10-fold increase in potency and equipotency, resp., to the natural product. These findings point the way to more focused structure activity relationship studies.

Journal of the American Chemical Society published new progress about Antitumor agents. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Product Details of C5H6N2OS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lam, P. Y. S.; Deudon, S.; Hauptman, E.; Clark, C. G. published the artcile< α-Nitrogen-activating effect in the room temperature copper-promoted N-arylation of heteroaryl carboxamides with phenylsiloxane or 4-tolylboronic acid>, Product Details of C5H6N2OS, the main research area is nitrogen heteroaromatic carboxamide phenylsiloxane arylation; tolylboronate nitrogen heteroaromatic carboxamide arylation; cross coupling nitrogen heteroaromatic carboxamide phenylsiloxane.

α-N-containing heteroaryl carboxamides undergo Cu-promoted N-phenylation with hypervalent PhSi(OMe)3 at room temperature, in the absence of base and in air. Arylboronic acid can substitute for PhSi(OMe)3 as the organometalloid. The α-heteroatom chelating effect is in the decreasing order of N > O, S. This discovery opens up the possibility of using other α-N functional groups to direct the N-arylation of peptides and simple amides under conditions as mild as that of amide bond formation.

Tetrahedron Letters published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaromatic). 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Product Details of C5H6N2OS.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hughes, Rachael A.; Thompson, Stewart P.; Alcaraz, Lilian; Moody, Christopher J. published the artcile< Total Synthesis of the Thiopeptide Antibiotic Amythiamicin D>, SDS of cas: 31825-95-3, the main research area is amythiamicin antibiotic thiopeptide total synthesis; pyridine trisubstituted preparation hetero Diels Alder reaction acetylenamine ethoxyazadiene.

The thiopeptide (or thiostrepton) antibiotics are a class of sulfur containing highly modified cyclic peptides with interesting biol. properties, including reported activity against MRSA and malaria. This work describes the total synthesis of the thiopeptide natural product amythiamicin D (I), and the key step is a biosynthesis-inspired hetero-Diels-Alder route to the pyridine core of the thiopeptide. Preliminary studies using a range of serine-derived 1-ethoxy-2-azadienes established that hetero-Diels-Alder reaction with N-acetylenamines proceeded efficiently under microwave irradiation to give 2,3,6-trisubstituted pyridines. The thiazole building blocks of the antibiotic were obtained by either classical Hantzsch reactions or by dirhodium(II)-catalyzed chemoselective carbene N-H insertion followed by thionation, and were combined to give the bis-thiazole that forms the left-hand fragment of the antibiotic. The key Diels-Alder reaction of a tris-thiazolylazadiene II with benzyl 2-(1-acetylaminoethenyl)thiazole-4-carboxylate gave the core tetrathiazolyl pyridine III, which was elaborated into the natural product by successive incorporation of glycine and bis-thiazole fragments followed by macrocyclization.

Journal of the American Chemical Society published new progress about Cyclic peptides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiopeptides). 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, SDS of cas: 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chen, Fei; Chai, Hui; Su, Ming-Bo; Zhang, Yang-Ming; Li, Jia; Xie, Xin; Nan, Fa-Jun published the artcile< Potent and Orally Efficacious Bisthiazole-Based Histone Deacetylase Inhibitors>, Quality Control of 31825-95-3, the main research area is bisthiazole histone deacetylase inhibitor preparation evaluation exptl autoimmune encephalomyelitis; Histone deacetylase inhibitors; bisthiazole; largazole.

Inspired by the thiazole-thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors was prepared and evaluated. Compound I was evaluated in vivo in an exptl. autoimmune encephalomyelitis (EAE) model and found to be orally efficacious in ameliorating clin. symptoms of EAE in mice.

ACS Medicinal Chemistry Letters published new progress about Experimental allergic encephalomyelitis (model for multiple sclerosis). 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Quality Control of 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Desaubry, Laurent; Wermuth, Camille G.; Boehrer, Annie; Marescaux, Christian; Bourguignon, Jean-Jacques published the artcile< Synthesis and anticonvulsant properties of BW A78U structurally-related compounds>, Application In Synthesis of 31825-95-3, the main research area is BW A78U analog anticonvulsant.

Several analogs, e.g. I, of the anticonvulsant BW A78U have been synthesized and tested for their anticonvulsant properties, providing preliminary data concerning the structural requirements for this family of drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticonvulsants. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Application In Synthesis of 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aulakh, Virender S.; Ciufolini, Marco A. published the artcile< An improved synthesis of pyridine-thiazole cores of thiopeptide antibiotics>, Synthetic Route of 31825-95-3, the main research area is pyridinethiazole core thiopeptide antiobiotic preparation.

The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise route to pyridine cores of thiopeptide antibiotics.

Journal of Organic Chemistry published new progress about Bohlmann-Rahtz reaction. 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Synthetic Route of 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lam, P. Y. S.; Deudon, S.; Hauptman, E.; Clark, C. G. published the artcile< α-Nitrogen-activating effect in the room temperature copper-promoted N-arylation of heteroaryl carboxamides with phenylsiloxane or 4-tolylboronic acid>, Application In Synthesis of 31825-95-3, the main research area is nitrogen heteroaromatic carboxamide phenylsiloxane arylation; tolylboronate nitrogen heteroaromatic carboxamide arylation; cross coupling nitrogen heteroaromatic carboxamide phenylsiloxane.

α-N-containing heteroaryl carboxamides undergo Cu-promoted N-phenylation with hypervalent PhSi(OMe)3 at room temperature, in the absence of base and in air. Arylboronic acid can substitute for PhSi(OMe)3 as the organometalloid. The α-heteroatom chelating effect is in the decreasing order of N > O, S. This discovery opens up the possibility of using other α-N functional groups to direct the N-arylation of peptides and simple amides under conditions as mild as that of amide bond formation.

Tetrahedron Letterspublished new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaromatic). 31825-95-3 belongs to class thiazole, and the molecular formula is C5H6N2OS, Application In Synthesis of 31825-95-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 31825-95-3, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.31825-95-3, Name is 2-Methylthiazole-4-carboxamide, molecular formula is C5H6N2OS. In a patent, introducing its new discovery.

The thiopeptide (or thiostrepton) antibiotics are a class of sulfur containing highly modified cyclic peptides with interesting biological properties, including reported activity against MRSA and malaria. Described herein is the total synthesis of the thiopeptide natural product amythiamicin D, which utilizes a biosynthesis-inspired hetero-Diels-Alder route to the pyridine core of the antibiotic as a key step. Preliminary studies using a range of serine-derived 1-ethoxy-2-azadienes established that hetero-Diels-Alder reaction with N-acetylenamines proceeded efficiently under microwave irradiation to give 2,3,6-trisubstituted pyridines. The thiazole building blocks of the antibiotic were obtained by either classical Hantzsch reactions or by dirhodium(II)- catalyzed chemoselective carbene N-H insertion followed by thionation, and were combined to give the bis-thiazole that forms the left-hand fragment of the antibiotic. The key Diels-Alder reaction of a tris-thiazolyl azadiene with benzyl 2-(1-acetylaminoethenyl)thiazole-4-carboxylate gave the core tetrathiazolyl pyridine, which was elaborated into the natural product by successive incorporation of glycine and bis-thiazole fragments followed by macrocyclization.

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Reference：
Thiazole | C3H3801NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 31825-95-3, Name is 2-Methylthiazole-4-carboxamide,molecular formula is C5H6N2OS, is a conventional compound. this article was the specific content is as follows.Safety of 2-Methylthiazole-4-carboxamide

(Figure Presented) The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.

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Reference：
Thiazole | C3H3809NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.31825-95-3, Name is 2-Methylthiazole-4-carboxamide, molecular formula is C5H6N2OS. In a Article£¬once mentioned of 31825-95-3, Formula: C5H6N2OS

Heteroarylcarboxamides containing alpha-nitrogens undergo copper-promoted N-phenylation with hypervalent phenyl trimethylsiloxane at room temperature, in the absence of base and in air. Arylboronic acid can substitute for phenyl trimethylsiloxane as the organometalloid. The alpha-heteroatom chelating effect is in the decreasing order of N>O, S. This discovery opens up the possibility of using other alpha-nitrogen functional groups to direct the N-arylation of peptides and simple amides under conditions as mild as that of amide bond formation.

Heteroarylcarboxamides containing alpha-nitrogens undergo copper-promoted N-phenylation with hypervalent phenyl trimethylsiloxane at room temperature, in the absence of base and in air. Arylboronic acid can substitute for phenyl trimethylsiloxane as the organometalloid. The alpha-heteroatom chelating effect is in the decreasing order of N>O, S. This discovery opens up the possibility of using other alpha-nitrogen functional groups to direct the N-arylation of peptides and simple amides under conditions as mild as that of amide bond formation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C5H6N2OS, you can also check out more blogs about31825-95-3

Reference£º
Thiazole | C3H3808NS – PubChem,
Thiazole | chemical compound | Britannica