Category: 32137-76-1

In an article, published in an article, once mentioned the application of 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate,molecular formula is C10H9NO2S, is a conventional compound. this article was the specific content is as follows.Safety of Ethyl 1,3-benzothiazole-2-carboxylate

METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS

Methods and systems to generate 6-amino-6-deoxy-D-luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives

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Reference：
Thiazole | C3H7696NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 32137-76-1, An article , which mentions 32137-76-1, molecular formula is C10H9NO2S. The compound – Ethyl 1,3-benzothiazole-2-carboxylate played an important role in people’s production and life.

A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular docking studies were done to assess the binding mode and interactions of synthesized hits at binding site of receptor Peroxisome proliferator-activated receptor, PPAR-gamma or PPARG (PDB 1FM9). Among the synthesized compounds, nine compounds were selected on the basis of docking score and evaluated for their in vivo anti-diabetic activity using Oral Glucose Tolerance Test (OGTT) in normal rats followed by Streptozotocin (STZ) – induced diabetes. Results indicated that compound M-14 (161.39 ¡À 4.38) showed the highest reduction of blood glucose level comparable to that of the standard drug glibenclamide (140.29 ¡À 1.24) in STZ model. Other compounds exhibited moderate to good anti hyperglycaemic activity. ADME studies was done using Molinspiration online software, revealed that all compounds (except M-11) are likely to be orally active as they obeyed Lipinski’s rule of five.

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Reference£º
Thiazole | C3H7713NS – PubChem,
Thiazole | chemical compound | Britannica

32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 32137-76-1, COA of Formula: C10H9NO2S

The invention discloses a substituted amide phenol compound and its preparation method, pharmaceutical composition and use, the compound has the following structure shown in formula I, wherein Z, L and Q are defined as in the specification and in the claims stated. The compounds of this invention and its pharmaceutical composition, can be used for preparing the prevention and/or treatment of ribonucleotide reductase related tumor. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C10H9NO2S. In my other articles, you can also check out more blogs about 32137-76-1

Reference£º
Thiazole | C3H7689NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 32137-76-1, An article , which mentions 32137-76-1, molecular formula is C10H9NO2S. The compound – Ethyl 1,3-benzothiazole-2-carboxylate played an important role in people’s production and life.

A new paramagnetic ligand, betaDTDA, and its coordination complex with Fe(hfac)2 are reported (betaDTDA = 4-(benzothiazol-2?-yl)-1,2,3,5-dithiadiazolyl; hfac = 1,1,1,5,5,5-hexafluoroacetylacetonato-). The neutral radical betaDTDA is the first dithiadiazolyl ligand designed to include an electropositive sulphur moiety outside the thiazyl heterocycle, increasing the capacity for supramolecular, structure-directing electrostatic contacts and enabling new pathways for magnetic exchange. The Fe(hfac)2(betaDTDA) complex is composed of a hs-Fe(ii) center with the three bidentate ligands arranged about the ion in a distorted octahedral 6-coordinate environment. The magnetic properties of crystalline Fe(hfac)2(betaDTDA) are consistent with strong antiferromagnetic (AF) coupling between the metal and ligand moments, giving rise to a well-defined Stotal = 3/2 ground state that is the only thermally populated state below 40 K. Below 4 K, this complex exhibits slow relaxation of the magnetization detected by ac susceptibility measurements consistent with a single-molecule magnet (SMM) behaviour.

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Reference£º
Thiazole | C3H7717NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate.

Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through CDI-mediated direct coupling of benzo[d]thiazole-2-carboxylic acids with aromatic amines using a three step methodology which includes a green protocol for synthesis of ethyl benzo[d]thiazole-2-carboxylates, precursor of the desired carboxylic acids. The compounds were evaluated in vitro for anti-tubercular activity against M. tuberculosis H37Rv (ATCC27294 strain). Thirty-two compounds exhibiting MIC values in the range of 0.78?6.25 mug/mL (1.9?23 muM) were subjected to cell viability test against RAW 264.7 cell lines and thirty compounds were found to be non-toxic (<50% inhibition). The most active compounds with MIC of 0.78 mug/mL (e.g., 4i, 4n, 4s, 4w, 6f, 6h, 6u, 7e, 7h, 7p, 7r and 7w) exhibit therapeutic index of 64. The structure activity relationship of the N-arylbenzo[d]thiazole-2-carboxamides has been established for anti-mycobacterial activity. Molecular docking suggests that the compounds 7w, 4i and 4n bind to the catalytic site of the enzyme ATP Phosphoribosyltransferase (HisG) and might be attributed to their anti-TB potential. These can serve as a new starting point for the development of anti-TB agents with therapeutic potential. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate. In my other articles, you can also check out more blogs about 32137-76-1

Reference£º
Thiazole | C3H7677NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 32137-76-1, Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate

Methoxy- and ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8(2-).They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

Methoxy- and ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8(2-).They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 32137-76-1, in my other articles.

Reference£º
Thiazole | C3H7695NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 32137-76-1, SDS of cas: 32137-76-1

Methoxy- and ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8(2-).They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

Methoxy- and ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8(2-).They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.SDS of cas: 32137-76-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 32137-76-1, in my other articles.

Reference£º
Thiazole | C3H7695NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 32137-76-1, Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate

Introduction: The absence of microbial growth and resistance to oxidative deterioration in fruits of Musa ¡Á paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites. Objective: In order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essential oils (EOs) from fruits of different geographical areas of M. ¡Á paradisiaca, gas chromatography-mass spectroscopy (GC-MS) principal component data correlation analysis is complemented with antimicrobial assays and phytochemical and bioautographic antioxidant fingerprints with thin layer chromatography (TLC). Methodology: An EO was obtained by steam distillation and subjected to GC-MS and TLC for metabolomic profiling from fruit pulp. The antimicrobial potential was tested in both Escherichia coli as a gram negative and Bacillus subtilis as a gram positive microbe. Potential antioxidant metabolites were identified through TLC-bioautography and GC-MS analysis of active zones. Results: A maximum of 0.56% v/w EO was isolated from fruit pulps of M. ¡Á paradisiaca. Minimum inhibitory concentrations (MICs) against B. subtillis and E. coli were 0.25 and 0.35?mug/mL, respectively. Thus, 56 metabolites were identified through GC-MS. The major abundant antimicrobial metabolites found in EOs are alpha-thujene, gamma-terpinene, alpha- and beta-pinene, sabinene, beta-myrcene, limonene, alpha-capaene, caryophyllene and (Z,E)-alpha farnesene. Aceteugenol, palmitic acid, stearic acid, palmitin, and stearin were identified as antioxidant metabolites. Principal component analysis of metabolite data reveals correlations and a clear separation based on metabolites obtained from various areas. Conclusion: The data generated using metabolic profiling and cluster analysis helped to identify antimicrobial and antioxidant compounds in M. ¡Á paradisiaca.

Introduction: The absence of microbial growth and resistance to oxidative deterioration in fruits of Musa ¡Á paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites. Objective: In order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essential oils (EOs) from fruits of different geographical areas of M. ¡Á paradisiaca, gas chromatography-mass spectroscopy (GC-MS) principal component data correlation analysis is complemented with antimicrobial assays and phytochemical and bioautographic antioxidant fingerprints with thin layer chromatography (TLC). Methodology: An EO was obtained by steam distillation and subjected to GC-MS and TLC for metabolomic profiling from fruit pulp. The antimicrobial potential was tested in both Escherichia coli as a gram negative and Bacillus subtilis as a gram positive microbe. Potential antioxidant metabolites were identified through TLC-bioautography and GC-MS analysis of active zones. Results: A maximum of 0.56% v/w EO was isolated from fruit pulps of M. ¡Á paradisiaca. Minimum inhibitory concentrations (MICs) against B. subtillis and E. coli were 0.25 and 0.35?mug/mL, respectively. Thus, 56 metabolites were identified through GC-MS. The major abundant antimicrobial metabolites found in EOs are alpha-thujene, gamma-terpinene, alpha- and beta-pinene, sabinene, beta-myrcene, limonene, alpha-capaene, caryophyllene and (Z,E)-alpha farnesene. Aceteugenol, palmitic acid, stearic acid, palmitin, and stearin were identified as antioxidant metabolites. Principal component analysis of metabolite data reveals correlations and a clear separation based on metabolites obtained from various areas. Conclusion: The data generated using metabolic profiling and cluster analysis helped to identify antimicrobial and antioxidant compounds in M. ¡Á paradisiaca.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: Ethyl 1,3-benzothiazole-2-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 32137-76-1, in my other articles.

Reference£º
Thiazole | C3H7699NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 32137-76-1, name: Ethyl 1,3-benzothiazole-2-carboxylate

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: Ethyl 1,3-benzothiazole-2-carboxylate, you can also check out more blogs about32137-76-1

Reference£º
Thiazole | C3H7712NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 32137-76-1, Name is Ethyl 1,3-benzothiazole-2-carboxylate, molecular formula is C10H9NO2S. In a Patent£¬once mentioned of 32137-76-1, name: Ethyl 1,3-benzothiazole-2-carboxylate

Antimicrobial resistance is rising at an alarming rate. The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Notably, the MEP pathway is present in bacteria and not mammals, which made the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to reduced chances of off-target interactions leading to side effects. The biophysical properties of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) and 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) were determined to aid discovery of novel inhibitors. Thermal shift screening was used as an initial filter to narrow down a library of compounds with thermal shifts greater than 1 C., which could indicate binding to the IspD and IspE enzymes. Follow-up studies were performed using isothermal titration calorimetry and enzymatic inhibition assays. Results from these studies have revealed compounds with high micromolar inhibition of both IspD from Escherichia coli and IspE from Burkholderia thailandensis. The hit compounds are used for future development of more potent IspD and IspE inhibitors.

Antimicrobial resistance is rising at an alarming rate. The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Notably, the MEP pathway is present in bacteria and not mammals, which made the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to reduced chances of off-target interactions leading to side effects. The biophysical properties of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) and 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) were determined to aid discovery of novel inhibitors. Thermal shift screening was used as an initial filter to narrow down a library of compounds with thermal shifts greater than 1 C., which could indicate binding to the IspD and IspE enzymes. Follow-up studies were performed using isothermal titration calorimetry and enzymatic inhibition assays. Results from these studies have revealed compounds with high micromolar inhibition of both IspD from Escherichia coli and IspE from Burkholderia thailandensis. The hit compounds are used for future development of more potent IspD and IspE inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Ethyl 1,3-benzothiazole-2-carboxylate. In my other articles, you can also check out more blogs about 32137-76-1

Reference£º
Thiazole | C3H7708NS – PubChem,
Thiazole | chemical compound | Britannica