Category: 32137-76-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of A (10 g, 48 mmol) in THF (50 mL) at 0C under nitrogen was added aq.NaOH (72ml, 2M, 145 mmol). Reaction mixture was stirred at room temperature for 30-120min, monitored by TLC. Mixture was acidified with aq.HCl (6M) to pH=3-4, and precipitate filtered to give 1 (7 g, 81%) as a white solid., 32137-76-1

32137-76-1 Ethyl 1,3-benzothiazole-2-carboxylate 640708, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Ethyl benzothiazole-2-carboxylate 4a (1 mmol) was taken in around bottom flask (10 mL). To it the aliphatic amine (4 equiv.) wasadded in excess along with (50 mg) of NH4Cl. The reaction mixturewas heated at 150 C for 2e3 h under magnetic stirring. Aftercompletion of reaction (TLC), the mixture was diluted using EtOAc,washed with1N HCl and brine, dried over anhydrous MgSO4 andconcentrated under reduced pressure to furnish the final productthat was then washed with cooled hexane.

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghonim, Aya E.; Ligresti, Alessia; Rabbito, Alessandro; Mahmoud, Ali Mokhtar; Di Marzo, Vincenzo; Osman, Noha A.; Abadi, Ashraf H.; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 154 – 170;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a 250 mL round bottom flask was added ethyl benzothiazole-2-carboxylate (1.0363 g, 5.0 mmol). 20 mL ethanol and 2 mL hydrazine hydrate were added followed by heating the solution to reflux for 6 hours. The reaction mixture was cooled to room temperature and solid precipitate was filtered, collected, and recrystallized in ethanol to yield benzo[d]thiazole-2-carbohydrazide (943.4 mg, 89.1% yield).

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY; Hagen, Timothy J.; Thompson, Michael; Troxell, Jeremy R.; Hartnett, Brian E.; (69 pag.)US2018/271098; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

32137-76-1, Ethyl 1,3-benzothiazole-2-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6Synthesis of benzothiazole-2-carboxamide (8)Benzothiazole-2-carboxamide was synthesized from ethyl benzothiazole-2-carboxylate according to the following reaction scheme. In particular, commercially available ethyl benzothiazole-2-carboxylate 6 (2.4 mmol, 0.5 g) was dissolved in 34 mL MeOH and purged with NH3 gas. Conversion to the product was monitored by TLC (3 Hexane: 2 EtOAc). Following complete conversion to the product 8 (30 min), the solvent was removed in vacuo. Agilent HPLC displayed 100% conversion to the desired product 8 with a single peak at 8.0 min. The solid white compound was used in the subsequent step without purification. ESI-MS: m/z calcd for C8H6N2OS 179.02 (M+H)+, 179.88 found (100%) (see LC/MS spectra of FIG. 17A and NMR spectra of FIG. 17B)., 32137-76-1

32137-76-1 Ethyl 1,3-benzothiazole-2-carboxylate 640708, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.; US2011/224442; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica