Category: 324579-90-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

0.15 mmol6-(2-chloropyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole,0.30 mmol 4-cyclopropyl-2-aminothiazole,0.025 mmol of tris(dibenzylideneacetone) dipalladium,0.028 mmol 2-dicyclohexylphosphor-2′,6′-diisopropoxy-1,1′-biphenyl,Mix 0.5 mmol cesium carbonate and 80 mL 1,4-dioxane.Put it on a vacuum pump for 10 minutes.Remove the water in the reaction material,In an argon atmosphere,110 ¡ãC reaction overnight;After the reaction is completed, naturally cool to room temperature.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.Dry the resulting organic layer under reduced pressureThen column chromatography,N-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)pyrimidin-2-amine is obtained;0.5mmolN-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)Pyrimidin-2-amine,Mix 5 mL of ethanol with 0.5mL of hydrochloric acid 1,4-dioxane solution.70 ¡ã C reaction 2h;After the reaction is complete, the resulting material is adjusted to pH 8 with saturated sodium bicarbonate solution.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.The resulting organic layer was spin-dryed under reduced pressure and then subjected to column chromatography.The target product N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine was obtained as a white solid.(N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine.Compound No. 2n)., 324579-90-0

As the paragraph descriping shows that 324579-90-0 is playing an increasingly important role.

Reference£º
Patent; South Medical University Zhongxiyi Binding Hospital; Zhu Zhibo; Zhou Jin; Yang Zike; Wang Hao; Liao Bohong; (21 pag.)CN107721991; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of Compound J (5.6 g, 40 mmol) and CuBr (8.5 g, 60 mmol) in CH3CN (100 mL) was added dropwise t-BuONO (6.2 g, 7.2 mL, 60 mmol) at 0 ¡ãC. Then the reaction mixture was warmed to room temperature and further stirred for additional 30 mins. After that, the precipitate was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: 100percent petroleum ether) to afford the desired product K (3.5 g, 43 percent) as a light yellow oil containing small amount of petroleum ether. 1H NMR (400 MHz, CDC13): delta 6.77 (s, 1H), 2.00-1.95 (m, 1H), 0.94-0.85 (m, 4H)., 324579-90-0

The synthetic route of 324579-90-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei; WO2014/37480; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica