Category: 3292-77-1

Brief introduction of 3292-77-1

3292-77-1, 3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various fields.

3292-77-1, 2-Bromo-1-(thiazol-2-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-1-(thiazol-2-yl)ethanone (2.5 g; 12 mmol), acetonitrile (70 ml) and imidazole (1.65 g; 24 mmol) was stirred at ambient temperature for 1 hour. The mixture was evaporated to dryness and the residue partitioned between dichloromethane and water. The organic phase was separated, washed with saturated brine and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%). MP: 109-112 C. 1H NMR (DMSO d6, 400 MHz) delta: 5.6 (2H,s); 6.85-8.1 (5H,m).

3292-77-1, 3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Simple exploration of 3292-77-1

3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3292-77-1,2-Bromo-1-(thiazol-2-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(l,3-thiazol-2-yl)ethanone (54.2 mg, 0.26 mmol) is added to a solution of (R)-quinuclidin-3-yl 2-(methyl(phenyl)amino)-2-phenylacetate (C75)(92.2 mg, 0.26 mmol) in EtOAc (5 mL). The mixture is stirred at RT overnight. The solvent is evaporated to dryness and the crude is triturated with Et2theta. The yellow solid is collected by filtration (120 mg, 82% yield, bromide salt, mixture of diastereoisomers).1H NMR (300 MHz, DMSO-^6) ppm: 8.39 (d, 1 H), 8.25 (d, 1 H), 7.32 – 7.50 (m, 5 H), 7.19 – 7.30 (m, 2 H), 6.84 – 7.00 (m, 2 H), 6.67 – 6.85 (m, 1 H), 5.97 (s, 1 H), 5.23 – 5.38 (m, 1 H), 5.19 and 5.20 (s, 2 H), 4.04 – 4.29 (m, 1 H), 3.44 – 3.82 (m, 5 H), 2.76 and 2.77 (s, 3 H), 2.24 – 2.36 (m, 1 H), 1.45 – 2.13 (m, 4 H); LC-MS (ESI POS): 476.0 (MH+).

3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele; WO2010/72338; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica