Category: 348-40-3

Related Products of 348-40-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine

We describe the synthesis and photophysical properties of 11 substituted 5-(benzothiazol-2-yl)-2?-deoxyuridine derivatives and oligodeoxyribonucleotides (ODNs) containing 5-(5,6-dimethoxybenzothiazol-2-yl)- 2?-deoxyuridine (dbtU), which was the strongest fluorescent derivative among those prepared. The fluorescence properties of dbtU itself and ODNs containing dbtU show the same tendency of being weaker in both neutral and acidic solution and stronger in basic solution. The ODNs (15mer) containing 16 combinations of 5?-XbtU-3? and 5?-btUY-3?, where X, Y = A, T, G, or C, were synthesized, and their fluorescence intensity and quantum yield in basic solution were compared. On average, only the ODN with the 5?-G btU-3? sequence shows a 7.9-fold lower fluorescence intensity than the other sequences. Ab initio calculations of 5?-G btU-3? and 5?-btUG-3? as models under basic conditions suggest that the lower fluorescence of the ODN containing the 5?-GbtU-3? sequence is caused by a wider overlap between stacked guanine (Gua) and btUra than that of the 5?- btUG-3? sequence and that the HOMO is delocalized not only on btUra but also on Gua.

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Reference：
Thiazole | C3H10343NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3, HPLC of Formula: C7H5FN2S

In the current study, sixteen novel derivatives of (R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethanamine were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Chemical structures together with purity of the synthesized compounds were substantiated by IR, 1H, 13C, 19F NMR, high resolution mass spectrometry and elemental analysis. The optical activities were confirmed by optical rotation measurements. The synthesized compounds were evaluated for their AChE and BChE inhibitory activities. In addition, the cytotoxicity of the most active compounds was investigated against human cell lines employing XTT tetrazolium salt reduction assay and xCELLigence system allowing a label-free assessment of the cells proliferation. Our results demonstrated that the inhibitory mechanism was confirmed to be pseudo-irreversible, in line with previous studies on carbamates. Compounds indicated as 3b, 3d, 3l and 3n showed the best AChE inhibitory activity of all the evaluated compounds and were up to tenfold more potent than standard drug rivastigmine. The binding mode was determined using state-of-the-art covalent docking and scoring methodology. The obtained data clearly demonstrated that 3b, 3d, 3l and 3n benzothiazole carbamates possess high inhibitory activity against AChE and BChE and concurrently negligible cytotoxicity. In conclusion, our results indicate, that these derivatives could be promising in an effective therapeutic intervention for Alzheimer’s disease.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C7H5FN2S, you can also check out more blogs about348-40-3

Reference：
Thiazole | C3H10478NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3, SDS of cas: 348-40-3

A new series of N,O-acetals were prepared via a simple one-pot reaction by the condensation of 2-amino-methybenzothiazole with aldehydes and alcohols. The title compounds were obtained in moderate to good yields in the presence of acid catalyst. Bioassay results indicated that some synthesized compounds had good herbicidal activity against both dicotyledon and monocotyledon weeds. This investigation provided a new type of herbicidal lead compounds, as well as its facile preparation method.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 348-40-3. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10590NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Patent，once mentioned of 348-40-3, HPLC of Formula: C7H5FN2S

A compound of formula (I) wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a ?Benzoazolylpiperazine Compound?), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson?s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington?s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of Benzoazolylpiperazine Compound are disclosed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C7H5FN2S. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10613NS – PubChem,
Thiazole | chemical compound | Britannica

348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 348-40-3, SDS of cas: 348-40-3

As an aspect of our ongoing research in search of new antimicrobial armamentarium, a series of 1,2,4-triazol-3-ylthio-acetamides was constructed and in vitro analyzed for their antimicrobial activity against several bacteria and fungi. Aiming to establish an increased potency, the bioassay results were matched to those of 1,3,4-oxadiazoles, utilized previously. Remarkably, 1,2,4-triazoles were found to possess a good spectrum of antifungal potency, which eventually suggested the azole template as an essential pharmacophore to diversify the biological occupations of the attendant molecules. However, it was noticed that the potency of final analogs against each strain placed reliance on the type of substituent present on benzothiazole ring. The structures of final compounds were confirmed with the aid of IR, 1H NMR, 13C NMR spectroscopy and CHN analysis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 348-40-3. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10524NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3, Product Details of 348-40-3

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro antibacterial activity was evaluated.The 1,4-benzothiazine intermediates, which by Gould-Jacobs quinoline synthesis produced pyridobenzothiazine acids, were prepared by hydrolytic basic cleavage of substituted 2-aminobenzothiazoles and successive cyclocondensation with 1-bromo-2-chloroethane or alternatively with monochloroacetic acid, hence reduction by LiAlH4.The pyridobenzothiazine acids 10c, 30, and 31 show potent antibacterial activities against Gram-positive and Gram-negative pathogens.Structure-activity relationships are discussed.The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid (31) (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species (rat, dog, monkey, man).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 348-40-3. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10547NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 348-40-3, C7H5FN2S. A document type is Article, introducing its new discovery., SDS of cas: 348-40-3

In an attempt to find new agents to fight against microbial infections, a series of coumarin-based 1,3,4-oxadiazol-2ylthio-N-phenyl/benzothiazolyl acetamides was synthesized starting from coumarin-3-carboxylic acid ethyl ester obtained through Knoevenagel and Pinner reaction. In vitro antimicrobial activity against several bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, S. flexneri), fungi (A. niger, A. fumigatus, A. clavatus, C. albicans) and antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain was assessed. This study shows to what extent the presence of various electron withdrawing/donating substituents on the phenyl or benzothiazole ring affects the activity profiles of the newer molecules. The relationship between activity profiles (MICs, 3.12-25 mug/mL) and the lipophilic character (LogP) of the prepared products is also discussed and the MIC values of the active conjugates seem to correlate to some extent with the lipophilicity profiles. Two (5e and 6c) of the final analogues displayed promising antimycobacterial activity at 12.5 mug/mL of MIC, half fold potent to the standard drug pyrazinamide (6.25 mug/mL). Compounds were characterized by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.

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Reference：
Thiazole | C3H10485NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 348-40-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3

The copper diacetate catalysed reaction of triphenylbismuth diacetate with 6-aminobenzothiazole compounds afforded selectively the 6-phenylamino derivatives in good to high yields. A similar reaction with 2-aminothiazole or 2-amino-benzothiazole compounds gave mixtures of the monophenylated and diphenylated products 2-phenylaminothiazole and 2-(N-phenylamino)-3-N?- phenylthiazole derivatives, respectively, with the diphenyl product being predominant. Semi-empirical calculations with the SAM1/D and CHAIN methods performed on the evolution of a 2-aminobenzothiazole – copper(III) intermediate were in good qualitative agreement with the experimental results. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 348-40-3 is helpful to your research., Electric Literature of 348-40-3

Reference：
Thiazole | C3H10422NS – PubChem,
Thiazole | chemical compound | Britannica

348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 348-40-3, name: 6-Fluorobenzo[d]thiazol-2-amine

New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus 293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds 4a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds 4a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer (Hela) and kidney fibroblast cancer (COS-7) cell lines. Results indicated that all tested compounds have IC50 values >50 mumol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a-c, 5a, 6g,h, 6j, 6l, 6o and 7c,d were also assessed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 6-Fluorobenzo[d]thiazol-2-amine. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10456NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3, Quality Control of: 6-Fluorobenzo[d]thiazol-2-amine

Several iridium complexes {iridium(III)bis[2-(3-methoxyphenyl)-1,3- benzothiozolato-N,C2?] acetylacetonate (MeO-BT) 2Ir(acac), iridium(III)bis[2-(2,4-difluorophenyl)-1,3- benzothiozolato-N,C2?] acetylacetonate (2F-BT) 2Ir(acac), and iridium(III)bis[2-(2,4-difluorophenyl)-6-fluoro-1,3- benzothiozolato-N,C2?] acetylacetonate (3F-BT) 2Ir(acac)} having different substituents on 2-phenylbenzothiazole have been synthesized. Several iridium complexes {iridium(III)bis[2-(3- methoxyphenyl)-1,3-benzothiozolato-N,C2?] acetylacetonate (MeO-BT)2Ir(acac), iridium(III)bis[2-(2,4-difluorophenyl)-1,3- benzothiozolato-N,C2?] acetylacetonate (2F-BT) 2Ir(acac), and iridium(III)bis[2-(2,4-difluorophenyl)-6-fluoro-1,3- benzothiozolato-N,C2?] acetylacetonate (3F-BT) 2Ir(acac)} having different substituents on 2-phenylbenzothiazole have been synthesized. The phosphorescent light emitting diodes (PHOLEDs) using these iridium complexes as dopant emitters were fabricated. The experimental results revealed that the emissive colors of PHOLEDs could be finely tuned by suitable modification of the substituents on the 2-phenylbenzothiazole ligands. Furthermore, these iridium complexes show better emissive properties than the known iridium(III)bis(2-phenylbenzothiozolato-N,C2?) acetylacetonate (BT)2Ir(acac).

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 348-40-3 is helpful to your research., Quality Control of: 6-Fluorobenzo[d]thiazol-2-amine

Reference：
Thiazole | C3H10435NS – PubChem,
Thiazole | chemical compound | Britannica