Category: 349-49-5

349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 349-49-5, Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine

4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine. In my other articles, you can also check out more blogs about 349-49-5

Reference：
Thiazole | C3H4943NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 349-49-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5

The activation of the NF-kappaB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival mechanism, we developed new thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-kappaB activity. Optimization of the hit compound, identified in a NF-kappaB reporter gene assay, led to compound 9b, exhibiting a cellular IC50 for NF-kappaB inhibition of 0.3 muM while retaining a potent EGFR kinase inhibition (IC50 = 60 nM). The dual inhibitors showed a higher potency than gefitinib to inhibit cell growth of EGFR-overexpressing tumor cell lines in vitro and in a xenograft model in vivo, while no signs of toxicity were observed. An investigation of the molecular mechanism of NF-kappaB suppression revealed that the dual inhibitors depleted the transcriptional coactivator CREB-binding protein from the NF-kappaB complex in the nucleus.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 349-49-5 is helpful to your research., Application of 349-49-5

Reference：
Thiazole | C3H4913NS – PubChem,
Thiazole | chemical compound | Britannica

349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 349-49-5, Recommanded Product: 349-49-5

This invention relates to azabicyclo[4.1.0]hept-4-yl derivatives and their use as pharmaceuticals.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 349-49-5. In my other articles, you can also check out more blogs about 349-49-5

Reference：
Thiazole | C3H4894NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Patent，once mentioned of 349-49-5, Computed Properties of C4H3F3N2S

The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C4H3F3N2S, you can also check out more blogs about349-49-5

Reference：
Thiazole | C3H4903NS – PubChem,
Thiazole | chemical compound | Britannica

349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 349-49-5, SDS of cas: 349-49-5

We report herein a synthetic protocol for the preparation of 1,3-dibromo-1,1-difluoro-2-propanone, a new synthon used for the first time in a reaction with aromatic amines and sodium thiocyanate, leading to thiazoles which are useful candidates in drug discovery programs. The new synthon allows to introduce a bromodifluoromethyl group at the C4 of the thiazole, and it is amenable of further transformation such as the Br/F exchange useful in radiopharmaceutics. Application of the strategy to the preparation of a precursor of the biologically relevant DF2755Y is also reported.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 349-49-5. In my other articles, you can also check out more blogs about 349-49-5

Reference：
Thiazole | C3H4892NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 349-49-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Patent，once mentioned of 349-49-5

The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 349-49-5 is helpful to your research., Reference of 349-49-5

Reference：
Thiazole | C3H4904NS – PubChem,
Thiazole | chemical compound | Britannica

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Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions.

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Reference：
Thiazole | C3H4923NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 349-49-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 349-49-5, C4H3F3N2S. A document type is Article, introducing its new discovery.

An efficient C-H heteroarylation of heteroarenes is achieved through visible-light photoredox-catalyzed diazotization of heteroarylamines in situ by tBuONO at room temperature. A library of functionalized biheteroaryls is obtained by using this protocol. The reaction avoids the use of transition-metal catalysts, additives, and acidic reaction medium.

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Reference：
Thiazole | C3H4932NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine,molecular formula is C4H3F3N2S, is a conventional compound. this article was the specific content is as follows.Quality Control of: 4-(Trifluoromethyl)thiazol-2-amine

A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.

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Reference：
Thiazole | C3H4935NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5, Computed Properties of C4H3F3N2S

Treatment of 2-trifluoroacetamido-4-(trifluoromethyl)thiazole with two equivalents of n-butyllithium at -78 deg C produced the thiazole dianion 5 in situ, which reacted preferentially at the 5-position with a variety of electrophiles.These electrophiles include: an aldehyde, ketone, chloroformate, acid chloride, phosphorus oxychloride, silicon chloride, and disulfide.Dianion 5 also combined with dibromodifluoromethane at -98 deg C to give the corresponding 5-(bromodifluoromethyl)thiazole 7, which is an unusual reaction for an aromatic or heteroaromatic system.Compound 7 was converted to a 4,5-bis-(trifluoromethyl)thiazole 8 using tetrabutylammonium fluoride.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C4H3F3N2S, you can also check out more blogs about349-49-5

Reference：
Thiazole | C3H4893NS – PubChem,
Thiazole | chemical compound | Britannica