Category: 349-49-5

349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 349-49-5, Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine

4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine. In my other articles, you can also check out more blogs about 349-49-5

Reference：
Thiazole | C3H4943NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 349-49-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5

The activation of the NF-kappaB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival mechanism, we developed new thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-kappaB activity. Optimization of the hit compound, identified in a NF-kappaB reporter gene assay, led to compound 9b, exhibiting a cellular IC50 for NF-kappaB inhibition of 0.3 muM while retaining a potent EGFR kinase inhibition (IC50 = 60 nM). The dual inhibitors showed a higher potency than gefitinib to inhibit cell growth of EGFR-overexpressing tumor cell lines in vitro and in a xenograft model in vivo, while no signs of toxicity were observed. An investigation of the molecular mechanism of NF-kappaB suppression revealed that the dual inhibitors depleted the transcriptional coactivator CREB-binding protein from the NF-kappaB complex in the nucleus.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 349-49-5 is helpful to your research., Related Products of 349-49-5

Reference：
Thiazole | C3H4913NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 349-49-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine. In a document type is Patent, introducing its new discovery.

Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity of, e.g., the inhibition of, one or more members of the TAM family kinases.

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Reference：
Thiazole | C3H4925NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Patent，once mentioned of 349-49-5, Formula: C4H3F3N2S

ARYL SULFONES AND USES RELATED THERETO

Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C4H3F3N2S, you can also check out more blogs about349-49-5

Reference：
Thiazole | C3H4931NS – PubChem,
Thiazole | chemical compound | Britannica

349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 349-49-5, Safety of 4-(Trifluoromethyl)thiazol-2-amine

PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 4-(Trifluoromethyl)thiazol-2-amine. In my other articles, you can also check out more blogs about 349-49-5

Reference：
Thiazole | C3H4915NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5, Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine

alpha- or beta-Trifluoromethyl epoxysulfones: new C3 reagents for heterocyclisation

The syntheses of alpha- and beta-trifluoromethyl epoxysulfones 1 and 2 are described.Compound 1 reacts with nucleophiles and bis-nucleophiles to furnish trifluoromethyl ketones and trifluoromethyl heterocycles in good yield, while its isomer 2 leads to the opposite thiazole regioisomers with thioamides. – Keywords: Trifluoromethyl epoxysulfones; Heterocyclisation; Regioisomers; NMR spectroscopy; IR spectroscopy

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Reference：
Thiazole | C3H4899NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5, Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine

alpha- or beta-Trifluoromethyl epoxysulfones: new C3 reagents for heterocyclisation

The syntheses of alpha- and beta-trifluoromethyl epoxysulfones 1 and 2 are described.Compound 1 reacts with nucleophiles and bis-nucleophiles to furnish trifluoromethyl ketones and trifluoromethyl heterocycles in good yield, while its isomer 2 leads to the opposite thiazole regioisomers with thioamides. – Keywords: Trifluoromethyl epoxysulfones; Heterocyclisation; Regioisomers; NMR spectroscopy; IR spectroscopy

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 4-(Trifluoromethyl)thiazol-2-amine, you can also check out more blogs about349-49-5

Reference：
Thiazole | C3H4899NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 349-49-5, An article , which mentions 349-49-5, molecular formula is C4H3F3N2S. The compound – 4-(Trifluoromethyl)thiazol-2-amine played an important role in people’s production and life.

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

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Reference£º
Thiazole | C3H4927NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 349-49-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article£¬once mentioned of 349-49-5

FLT3-ITD mutant has been observed in about 30% of AML patients and extensively studied as a drug discovery target. On the basis of our previous study that ibrutinib (9) exhibited selective and moderate inhibitory activity against FLT3-ITD positive AML cells, through a structure-guided drug design approach, we have discovered a new type II FLT3 kinase inhibitor, compound 14 (CHMFL-FLT3-213), which exhibited highly potent inhibitory effects against FLT3-ITD mutant and associated oncogenic mutations (including FLT3-D835Y/H/V, FLT3-ITD-D835Y/I/N/A/G/Del, and FLT3-ITD-F691L). In the cellular context 14 strongly affected FLT3-ITD mediated signaling pathways and induced apoptosis by arresting cell cycle into G0/G1 phase. In the in vivo studies 14 demonstrated an acceptable bioavailability (F = 19%) and significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (15 mg kg-1 day-1, TGI = 97%) without exhibiting obvious toxicity. Compound 14 might be a potential drug candidate for FLT3-ITD positive AML.

FLT3-ITD mutant has been observed in about 30% of AML patients and extensively studied as a drug discovery target. On the basis of our previous study that ibrutinib (9) exhibited selective and moderate inhibitory activity against FLT3-ITD positive AML cells, through a structure-guided drug design approach, we have discovered a new type II FLT3 kinase inhibitor, compound 14 (CHMFL-FLT3-213), which exhibited highly potent inhibitory effects against FLT3-ITD mutant and associated oncogenic mutations (including FLT3-D835Y/H/V, FLT3-ITD-D835Y/I/N/A/G/Del, and FLT3-ITD-F691L). In the cellular context 14 strongly affected FLT3-ITD mediated signaling pathways and induced apoptosis by arresting cell cycle into G0/G1 phase. In the in vivo studies 14 demonstrated an acceptable bioavailability (F = 19%) and significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (15 mg kg-1 day-1, TGI = 97%) without exhibiting obvious toxicity. Compound 14 might be a potential drug candidate for FLT3-ITD positive AML.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 349-49-5 is helpful to your research., Synthetic Route of 349-49-5

Reference£º
Thiazole | C3H4924NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 349-49-5, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a patent, introducing its new discovery.

The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation in an attempt to identify novel agents for pain treatment. During pre-clinical development, the 1,8-naphthyridine 2 demonstrated unacceptably high levels of irreversible covalent binding. Replacement of the 1,8-naphthyridine core by a pyrido[2,3-b]pyrazine led to the discovery of compound 26 which was shown to have significantly lower potential for the formation of reactive metabolites. Compound 26 was characterized as an orally bioavailable TRPV1 antagonist with moderate brain penetration. In vivo, 26 significantly attenuated carrageenan-induced thermal hyperalgesia (CITH) and dose-dependently reduced complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain after oral administration.

The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation in an attempt to identify novel agents for pain treatment. During pre-clinical development, the 1,8-naphthyridine 2 demonstrated unacceptably high levels of irreversible covalent binding. Replacement of the 1,8-naphthyridine core by a pyrido[2,3-b]pyrazine led to the discovery of compound 26 which was shown to have significantly lower potential for the formation of reactive metabolites. Compound 26 was characterized as an orally bioavailable TRPV1 antagonist with moderate brain penetration. In vivo, 26 significantly attenuated carrageenan-induced thermal hyperalgesia (CITH) and dose-dependently reduced complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain after oral administration.

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Reference£º
Thiazole | C3H4898NS – PubChem,
Thiazole | chemical compound | Britannica