Category: 35272-15-2

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Methyl-1,3-thiazole-4-carbonyl chloride To 2-methyl-1,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80¡ã C. for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80¡ã C. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound, 1.12 g. 1H NMR (DSMO) delta 8.34 (s, 1H), 2.80 (s, 3H)., 35272-15-2

The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Glaxo Group Limited; Hamblin, Julie Nicole; Jones, Paul Spencer; Keeling, Suzanne Elaine; Le, Joelle; Mitchell, Charlotte Jane; Parr, Nigel James; (136 pag.)US9326987; (2016); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: To a 100 mL round bottom flask equipped with a stir bar were added 2- methyl-l,3-thiazole-4-carboxylic acid (1.0 g, 6.98 mmol), potassium carbonate (3.86 g, 27.9 mmol), N,N-dimethylformamide (20 mL) and iodomethane (0.52 mL 8.38 mmol). The reaction mixture was stirred at room temperature over the weekend, diluted with ethyl acetate (100 mL) and washed with water (100 mL). The aqueous layer was then extracted with ethyl acetate (3×75 mL). The combined organic layer was washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel using hexanes:ethyl acetate = 80:20 to 50:50 in a gradient fashion, to give the desired product as an off-white solid (1.06 g, 97 percent). 1H NMR (300 MHz, CDCl3): delta 8.06 (s, IH), 3.95 (s, 3H), 2.78 (s, 3H).

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 32lambda/-(6-Bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide 2-Methyl-1 ,3-thiazole-4-carboxylic acid (4.59g) (available from Maybridge), HATU (13.41g) and DIPEA (16.80ml) were stirred in DMF (140ml) for 30min at 2O0C. 6-Bromo- 1 H-indazol-4-amine (3.4g) (available from Sinova) was added and the reaction stirred at 2O0C for 2 days. The solvent was reduced to ~40ml and the reaction mixture was applied across 5×70 g aminopropyl SPE cartridges and left to stand for 3h. The cartridges were eluted with DCM:methanol (1 :1 ) and the combined solvent was evaporated in vacuo. The residue was suspended in DCM:methanol, adsorbed onto Florisil.(R). and purified by chromatography on silica gel (10Og cartridge) eluting with 0 – 15percent gradient of methanol (containing 1percent triethylamine) in DCM over 60min to give title compound (1.02g). LC/MS Rt 0.95min m/z 337 [MH+]. Method B

35272-15-2 2-Methylthiazole-4-carboxylic acid 284728, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica