Category: 3581-89-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

(a) To a solution of n-butyllithium (24 ml, 0.06 mol, 2.5M in hexane) in 50 ml of ether under argon at -78 C. was added dropwise a solution of 5-methylthiazole (5 g, 0.05 mol) in 25 ml of ether. The mixture was stirred at -78 C. for 1 h, and then a solution of N-formyl-morpholine (5.5 ml 0.055 mol) in 30 ml of ether was added within 15 min. The mixture was stirred for 1 h at -78 C., then at 0–5 C. overnight. The reaction mixture was then extracted with 4N HCl (4*10 ml), the aqueous layers were combined, cooled in an ice-bath, and neutralized with sodium bicarbonate solution (pH 9). The aqueous layer was extracted with ether (4*20 ml), the organic layer was dried over magnesium sulfate and concentrated in vacuo. The residue was dried in vacuo to afford 4.5 g (70.8%%) of 5-methyl-2-thiazolylcarboxaldehyde.

3581-89-3, As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.

Reference：
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

To a solution of BuLi (1.6 M in hexanes, 12.6 mL, 20.2 mmol) in 25mL of diethyl ether at -78 0C, was added a solution of 5-methylthiazole (2.0 g, 20.2 mmol) in ether (6 mL), drop-wise and stirred at -78 0C for 1.5 h. A solution of DMF (2.33 mL, 30.3 mmol in ether (5 mL) was added at once and the reaction mixture was allowed to warm to room temperature and stirred overnight. Ice was added to the reaction mixture followed by the slow addition of 4N HCl. The mixture was taken up in a separating funnel, ether added (30 mL) and shaken. The organic layer was discarded. The aqueous layer was brought to pH -7.5 with solid NaHCO3 and extracted with ether twice. The ether layer was dried over Na2SO4 and concentrated, and the resulting crude 5-methylthiazole-2-carbaldehyde (1.6 g) was carried over to the next- step without purification., 3581-89-3

The synthetic route of 3581-89-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.

To a solution of bromide from Step 1 (18 g, 86 [MMOL)] in toluene (100 mL) was added thiourea (10.5 g, 138 [MMOL).] The reaction mixture was heated to [100C] for 1 h, cooled to rt, and the solvent removed under reduced pressure. The residue was dissolved in [CH2CI2] (100 mL), a saturated solution of [NAHC03] (75 mL) was added, and the mixture was vigorously stirred for 10 minutes. The organic layer was separated, dried [(NA2SO4),] filtered, and concentrated under reduced pressure. The residue was then recrystallized from [CH2CI2/HEXANES] to provide the product (10 g, 63%) as a white solid. [(C7H10N202S)] : LC-MS, RT 0.76 min, (M+H) [+] 187.0 ;’H NMR [(CDCI3)] : [6] 2.23 (s, 3H), 3.70 (s, 2H), 3.75 (s, 3H), 4.83-4. 95 (broad s, 2H)., 3581-89-3

As the paragraph descriping shows that 3581-89-3 is playing an increasingly important role.

Reference：
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2004/11446; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica