Category: 38205-60-6

38205-60-6, 38205-60-6, Name is 1-(2,4-Dimethylthiazol-5-yl)ethanone, molecular formula is C7H9NOS, belongs to thiazole compound, is a common compound. In a patnet, assignee is BOTYANSZKI, Janos, once mentioned the new application about 38205-60-6

Disclosed are compounds having formula I and related compositions and methods thereof. The compounds are useful for treating viral infections caused by the Flaviviridae family of viruses.

Disclosed are compounds having formula I and related compositions and methods thereof. The compounds are useful for treating viral infections caused by the Flaviviridae family of viruses.

38205-60-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 38205-60-6 is helpful to your research.

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Thiazole | C3H192NS – PubChem,
Thiazole | chemical compound | Britannica

38205-60-6, In an article, published in an article,authors is Bhalerao, Mahendra B., once mentioned the application of 38205-60-6, Name is 1-(2,4-Dimethylthiazol-5-yl)ethanone,molecular formula is C7H9NOS, is a conventional compound. this article was the specific content is as follows.

New bithiazolyl hydrazones (6a?l) have been first time synthesized by carrying novel one pot cyclocondensation of 5-acyl thiazoles (1a?b), thiosemicarbazide (2) and substituted phenacyl chlorides (4a?f) in freshly prepared ionic liquid, diisopropyl ethyl ammonium acetate (DIPEAc) at room temperature. The newly synthesized compounds have been evaluated for their antitubercular activity and the compounds 3b, 6a, 6b, 6d, 6e, 6f, 6g, and 6l have displayed noticeable antitubercular activity compared to Rifampicin with tolerable cytotoxicity. All these compounds were also screened for their antibacterial activity and found that, compounds 6j and 6k have exhibited a very good antibacterial activity. Molecular docking study has shown better harmony with the evaluation trend shown by these compounds under in vitro antitubercular screening.

New bithiazolyl hydrazones (6a?l) have been first time synthesized by carrying novel one pot cyclocondensation of 5-acyl thiazoles (1a?b), thiosemicarbazide (2) and substituted phenacyl chlorides (4a?f) in freshly prepared ionic liquid, diisopropyl ethyl ammonium acetate (DIPEAc) at room temperature. The newly synthesized compounds have been evaluated for their antitubercular activity and the compounds 3b, 6a, 6b, 6d, 6e, 6f, 6g, and 6l have displayed noticeable antitubercular activity compared to Rifampicin with tolerable cytotoxicity. All these compounds were also screened for their antibacterial activity and found that, compounds 6j and 6k have exhibited a very good antibacterial activity. Molecular docking study has shown better harmony with the evaluation trend shown by these compounds under in vitro antitubercular screening.

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Thiazole | C3H180NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

Example 111-[N,N-dimethylaminocarbonyl-methyl]-2-[2-(2,4-dimethylthiazol-5-yl)-quinolin- 6-yl]-3-cyclohexyl-1H-indole-6-carboxylic acid (Compound 212) Preparation of 6-bromo-2-(2,4-dimethyl-thiazol-5-yl)-quinoline (125): [0217] A mixture of 1.071 g (5.354 mmol) compound 110, 723 muL (5.354 mmol) 5- acety1-2,4-dimethylthiazole and 9.0 mL 10% KOH/ethanol (16.062 mmol KOH) in 60 mL ethanol was refluxed overnight under argon. It was then evaporated and the residue triturated with water. The solid crude product was filtered through a 250 mL silica pad using a 10% to 60% toluene-ethylacetate gradient to give 1.164g (68%) compound 125,1H-NMR (DMSO-d6): delta(ppm) 8.39 (d, 1H, J=8.7Hz), 8.27 (m, 1H), 7.88-7.86 (m, 3H), 2.68 (s, 3H), 2.64 (s, 3H).; Example 88 Step 1. 6-Bromo-2-(2,4-dimethyl-thiazol-5-y1)-quinoline (125)[0307] To a solution of KOH (10.32 (85%) g, 156.27 mmol) in anhydrous EtOH (700 mL) was added 2-amino-5-bromobenzaldehyde (10.42 g, 52.09 mmol) and 5-acety1- 2,4-dimethylthiazole (8.16 mL, 60.42 mmol). The mixture was stirred under Ar at 78 0C for 16 h and then cooled down in an ice-bath. It was neutralized to pH 7 with 5 N HCl and then evaporated to about 60 mL. Water (500 mL) was added. The precipitate formed were collected by filtration, washed thoroughly with water, and dried to give 125 (15.62 g, 94%).

38205-60-6, The synthetic route of 38205-60-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENELABS TECHNOLOGIES, INC.; WO2006/76529; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(2,4-Dimethyl-5-thiazolyl)-1-(3-pyridyl)ethanol 5-Acetyl-2,4-dimethylthiazole (2.5 g) in dry diethylether (10 ml) was added dropwise to a stirred solution of 3-lithiopyridine (from 3.5 g 3-bromopyridine) in diethylether at -70 C. After 3 hours the mixture was allowed to warm to room temperature. After a further 1 hour, aqueous sodium hydrogen carbonate was added and the organic layer was separated. The aqueous layer was extracted with diethylether. The material obtained from the combined organic layers was purified by flash chromatography to give the title compound, m.p. 107.5-109 C. 13 C Nmr (CDCl3) 16.3, 18.7, 32.7, 71.9, 123.1, 133.5, 137.9, 142.4, 146.9, 148.0 and 162.2 ppm.

38205-60-6, As the paragraph descriping shows that 38205-60-6 is playing an increasingly important role.

Reference£º
Patent; Astra Aktiebolag; US5607956; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica