Category: 38215-36-0

Role of fennel oil/ quercetin dual nano-phytopharmaceuticals in hampering liver fibrosis: Comprehensive optimization and in vivo assessment was written by Hafez, Dina Ashraf;Abdelmonsif, Doaa A.;Aly, Rania G.;Samy, Wael Mahmoud;Elkhodairy, Kadria A.;Abo Aasy, Noha Khalifa. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: 38215-36-0 The following contents are mentioned in the article:

The unmet medical needs related to liver fibrosis and its incurable effects bring to an urgent necessity to find new treatment strategies from which, nutra-pharmaceuticals and nanotechnol. are attracting a considerable interest. The natural flavonoid, quercetin and the essential oil of fennel were proposed for their proven antifibrotic activity. They were successfully loaded in lipid nanocapsules, which were furtherly coated with hyaluronic acid for enhanced CD44active targeting potential. Thorough in vitro optimization produced monodisperse nanocapsules (particle size; 36.78 nm and PDI <0.2). Coating with hyaluronic acid not only sustain quercetin release but also, induce an efficient time dependent accumulation in a highly CD44 expressing cell line, HepG2, opposite to the uncoated nanocapsules. lipid nanocapsules coated with hyaluronic acid and loaded with both quercetin and fennel oil proved a promising synergistic antifibrotic efficiency on rats with CCL4-induced liver fibrosis. In vivo results revealed a significant improvement in liver function tests along with a significant reduction in liver fibrosis markers. Based on the significant downregulation in both liver oxidative stress parameters and hepatic proinflammatory cytokines, mechanism of action can be elucidated to be through antioxidant enzymes activation and inhibition of inflammatory mediators. Concerning toxicity, no reported hematol., hepato-or nephrotoxicity with all formulations, guaranteeing their safety. Hence, tried combination holds a promising treatment to liver fibrosis. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Recommanded Product: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease was written by Wang, Jiao;Kong, Liang;Guo, Rui-Bo;He, Si-Yu;Liu, Xin-Ze;Zhang, Lu;Liu, Yang;Yu, Yang;Li, Xue-Tao;Cheng, Lan. And the article was included in Drug Delivery in 2022.Formula: C20H18N2O2S The following contents are mentioned in the article:

The blood-brain barrier (BBB) is a protective barrier for brain safety, but it is also a major obstacle to the delivery of drugs to the cerebral parenchyma such as the hippocampus, hindering the treatment of central nervous system diseases such as Alzheimers disease (AD). In this work, an anti-AD brain-targeted nanodrug delivery system by co-loading icariin (ICA) and tanshinone IIA (TSIIA) into Aniopep-2-modified long-circulating (Ang2-ICA/TSIIA) liposomes was developed. Low-d. lipoprotein receptor-related protein-1 (LRP1) was a receptor overexpressed on the BBB. Angiopep-2, a specific ligand of LRP1, exhibited a high binding efficiency with LRP1. Addnl., ICA and TSIIA, drugs with neuroprotective effects are loaded into the liposomes, so that the liposomes not only have an effective BBB penetration effect, but also have a potential anti-AD effect. The prepared Ang2-ICA/TSIIA liposomes appeared narrow dispersity and good stability with a diameter of 110 nm, and a round morphol. Cell uptake observations, BBB models in vitro, and imaging anal. in vivo showed that Ang2-ICA/TSIIA liposomes not only penetrate the BBB through endocytosis, but also accumulate in N2a cells or brain tissue. The pharmacodynamic anal. in vivo demonstrated that Ang2-ICA/TSIIA liposomes could improve AD-like pathol. features in APP/PS1 mice, including inhibiting neuroinflammation and oxidative stress, reducing apoptosis, protecting neurons, and improving cognitive function. Therefore, Ang2-ICA/TSIIA liposomes are considered a potentially effective therapeutic strategy for AD. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Colorful Luminescent Magnetic Supraparticles: Expanding the Applicability, Information Capacity, and Security of Micrometer-Scaled Identification Taggants by Dual-Spectral Encoding was written by Muessig, Stephan;Reichstein, Jakob;Miller, Franziska;Mandel, Karl. And the article was included in Small in 2022.Product Details of 38215-36-0 The following contents are mentioned in the article:

(Sub)micrometer-scaled identification (ID) taggants enable direct identification of arbitrary goods, thereby opening up application fields based on the possibility of tracking, tracing, and anti-counterfeiting. Due to their small dimensions, these taggants can equip in principle even the smallest subcomponents or raw materials with information. To achieve the demanded applicability, the mostly used optically encoded ID taggants must be further improved. Here, micrometer-scaled supraparticles with spectrally encoded luminescent and magnetically encoded signal characteristics are reported. They are produced in a readily customizable bottom-up fabrication procedure that enables precise adjustment of luminescent and magnetic properties on multiple hierarchy levels. The incorporation of commonly used magnetic nanoparticles and fluorescent dyes, resp., into polymer nanocomposite particles, establishes a convenient toolbox of magnetic and luminescent building blocks. The subsequent assembly of selected building blocks in the desired ratios into supraparticles grants for all the flexibility to freely adjust both signal characteristics. The obtained spectrally resolved visible luminescent and invisible magnetic ID signatures are complementary in nature, thus expanding applicability and information security compared to recently reported optical- or magnetic-encoded taggants. Addnl., the introduced ID taggant supraparticles can significantly enhance the coding capacity. Therefore, the introduced supraparticles are considered as next-generation ID taggants. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Product Details of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Product Details of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Structural and Optical Properties of Nanocrystalline 3-(2-Benzothiazolyl)-7-(diethylamino) Coumarin (C6) Thin Films for Optoelectronic Application was written by Ebied, Mostafa Saad;Dongol, Mahmoud;Ibrahim, Medhat;Nassary, Mohammed;Elnobi, Sahar;Abuelwafa, Amr Attia. And the article was included in Journal of Electronic Materials in 2022.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

In the current work, the structural and optical properties of thermally evaporated 3-(2-Benzothiazolyl)-7-(diethylamino) coumarin [Coumarin 6 (C6)] thin films on a pre-cleaned quartz substrate were studied as a function of the annealing temperature The influence of annealing on the structural, morphol., and mol. structures was investigated by x-ray diffraction (XRD), at. force microscopy (AFM), and Fourier transform IR (FTIR) spectroscopy, resp. The XRD and AFM results confirmed that the as-deposited and annealed films have nanostructural features (30.96-45.34 nm). Also, the increase in roughness of the C6 thin film surface resulted from particle agglomeration and coalescence. Optical constants of C6 thin films were derived from the transmittance T(λ) and reflectance, R(λ) measurements in the spectral range of 200-2500 nm. Anal. of the optical absorption coefficient data indicates that the type of electronic transition in these films is an indirect allowed transition. The estimated optical band gap was decreased from 2.12 eV to 2.01 eV as the annealing temperature was increased. Dispersion and dielec. parameters were determined as functions of the annealing temperature Lastly, nonlinear optical parameters such as the third-order nonlinear susceptibility, χ(3) and nonlinear refractive index, n₍₂₎ were estimated and influenced by annealing temperature The optical properties of C6 thin films were showed that C6 thin films would be used in a wide range of photonic applications Graphical Abstract: [graphic not available: see fulltext]. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition was written by Ganthala, Parimala Devi;Alavala, Sateesh;Chella, Naveen;Andugulapati, Sai Balaji;Bathini, Nagendra Babu;Sistla, Ramakrishna. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2022.Application of 38215-36-0 The following contents are mentioned in the article:

Erlotinib-based EGFR targeted therapy has proven significant clin. improvement against non-small cell lung cancer (NSCLC). However, the anticancer activity of Erlotinib (Ertb) is limited by the development of Ertb resistance and possess a challenge to clinicians and patients. To explore a better therapeutic strategy, we evaluated Ertb in combinations with different natural products. We identified that Ertb and Quercetin (Quer) combination is more synergistic against A549 and NCI H460 cells compared to Ertb with Fisetin/Carnosic acid/Luteolin. To further improve the efficacy and overcome the limitation of free therapeutics, Ertb and Quer loaded solid lipid nanoparticles (EQNPs) were prepared using Chitosan-MA-TPGS polymer by hot homogenization method. The drug-loaded nanoparticles (NPs) have shown high encapsulation efficiency (77% Ertb and 71.4% Quer) as well as small particle size of 87.3 ± 0.78 nm and pos. zeta potential + 13.4 ± 1.12 mV. At pH 5.5, Ertb and Quer were released at their highest levels. We found that, EQNPs decreased the expression of P-glycoprotein (P-gp) and nuclear epidermal growth factor receptor (nEGFR). EQNPs increased the uptake of Ertb and Quer, and apoptosis induction in Ertb resistant A549/ER cells. Further, in vivo EQNPs formulation have shown increased uptake of nanoparticles in the lung tissue and significantly reduced the expression of nEGFR. Thus, EQNPs may be developed as a targeted medicine with min. side effects for treatment of NSCLC to improve the quality of life and survival of NSCLC patients. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Application of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Application of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Oxygen Self-Sufficient Nanoplatform for Enhanced and Selective Antibacterial Photodynamic Therapy against Anaerobe-Induced Periodontal Disease was written by Sun, Xiaolin;Sun, Jiao;Sun, Yue;Li, Chunyan;Fang, Jiao;Zhang, Tianshou;Wan, Yao;Xu, Lin;Zhou, Yanmin;Wang, Lin;Dong, Biao. And the article was included in Advanced Functional Materials in 2021.Related Products of 38215-36-0 The following contents are mentioned in the article:

The hypoxic microenvironment, continuous oxygen consumption, and poor excitation light penetration depth during antimicrobial photodynamic therapy (aPDT) tremendously hinder the effects on bacterial inactivation. Herein, a smart nanocomposite with oxygen-self-generation is presented for enhanced and selective antibacterial properties against anaerobe-induced periodontal diseases. By encapsulating Fe3O4 nanoparticles, Chlorin e6 and Coumarin 6 in the amphiphilic silane, combined light (red and IR) stimulated aPDT is realized due to the increased conjugate structure, the corresponding red-shifted absorption, and the magnetic navigation performance. To address the hypoxic microenvironment problem, further modification of MnO2 nanolayer on the composites is carried out, and catalytical activity is involved for the decomposition of hydrogen peroxide produced in the metabolic processing, providing sufficient oxygen for aPDT in infection sites. Experiments in the cellular level and animal model proved that the rising oxygen content could effectively relieve the hypoxia in a periodontal pocket and enhance the ROS production, remarkably boosting aPDT efficacy. The increasing local level of oxygen also shows the selective inhibition of pathogenic and anaerobic bacteria, which determines the success of periodontitis treatment. Therefore, this finding is promising for combating anaerobic pathogens with enhanced and selective properties in periodontal diseases, even in other bacteria-induced infections, for future clin. application. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Related Products of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Related Products of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs was written by Chen, Yufei;Traore, Yannick L.;Walker, Lyndon;Yang, Sidi;Ho, Emmanuel A.. And the article was included in Drug Delivery and Translational Research in 2022.Related Products of 38215-36-0 The following contents are mentioned in the article:

Abstract: We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding site), and coumarin 6 PLGA-PEG nanoparticles (C6NP). The hydrophilic polyurethanes were utilized to 3D-print reservoir-type IVRs containing a tunable release controlling membrane (RCM) with varying thickness and adaptable micro porous structures (by altering the printing patterns and interior fill densities) for controlled sustained drug delivery over 14 days. FDM 3D printing of IVRs were optimized and implemented using a lab-developed Cartesian 3D printer. The structures were investigated by SEM (SEM) imaging and in vitro release was performed using 5 mL of daily-replenished vaginal fluid simulant (pH 4.2). The release kinetics of the IVR segments were tunable with various RCM (outer diameter to inner diameter ratio ranging from 1.12 to 2.61) produced from FDM 3D printing by controlling the printing perimeter to provide daily zero-order release of HCQ ranging from 23.54 ± 3.54 to 261.09 ± 32.49μg/mL/day. IgG, gp120 fragment, and C6NP release rates demonstrated pattern and in-fill d.-dependent characteristics. The current study demonstrated the utility of FDM 3D printing to rapidly fabricate complex micro-structures for tunable and sustained delivery of a variety of compounds including HCQ, IgG, gp120 fragment, and C6NP from IVRs in a controlled manner. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Related Products of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Poly (glycerol adipate) (PGA) backbone modifications with a library of functional diols: Chemical and physical effects was written by Jacob, Philippa L.;Ruiz Cantu, Laura A.;Pearce, Amanda K.;He, Yinfeng;Lentz, Joachim C.;Moore, Jonathan C.;Machado, Fabricio;Rivers, Geoffrey;Apebende, Edward;Fernandez, Maria Romero;Francolini, Iolanda;Wildman, Ricky;Howdle, Steven M.;Taresco, Vincenzo. And the article was included in Polymer in 2021.Application of 38215-36-0 The following contents are mentioned in the article:

Enzymically synthesized poly(glycerol adipate) (PGA) has shown a palette of key desirable properties required for a biomaterial to be considered a ′versatile polymeric tool′ in the field of drug delivery. PGA and its variations can self-assemble into nanoparticles (NPs) and interact at different levels with small active mols. PGA derivatives are usually obtained by functionalising the glyceryl side hydroxyl group present along the main polymer scaffold. However, if the synthetic pathways are not finely tuned, the self-assembling ability of these new polymeric modifications might be hampered by the poor amphiphilic balance. For this reason, we have designed a straightforward one-pot synthetic modification, using a small library of diols in combination with glycerol, aimed at altering the backbone of the polymer without affecting the hydrophilic glyceryl portion. The diols introduce addnl. functionality into the backbone of PGA alongside the secondary hydroxyl group already present. We have investigated how extra functionalities along the polymer backbone alter the final polymer reactivity as well the chem. and biol. properties of the nanoparticles. In addition, with the intent to further improve the green credentials of the enzymic synthesis, a solvent derived from renewable resources, (2-MeTHF) was employed for the synthesis of all the PGA-variants as a replacement for the more traditionally used and fossil-based THF. In vitro assays carried out to evaluate the potential of these novel materials for drug delivery applications demonstrated very low cytotoxicity characteristic against NIH 3T3 model cell line. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Application of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

RVG-functionalized reduction sensitive micelles for the effective accumulation of doxorubicin in brain was written by Xu, Jiangkang;Yang, Xiaoye;Ji, Jianbo;Gao, Yuan;Qiu, Na;Xi, Yanwei;Liu, Anchang;Zhai, Guangxi. And the article was included in Journal of Nanobiotechnology in 2021.Reference of 38215-36-0 The following contents are mentioned in the article:

Glioblastoma is a lethal neoplasm with few effective therapy options. As a mainstay in the current treatment of glioma at present, chemotherapeutic agents usually show inadequate therapeutic efficiency due to their low blood brain barrier traversal and brain targeting, together with tumor multidrug resistance. Novel treatment strategies are thus urgently needed to improve chemotherapy outcomes. Here, we report that nanomedicines developed by functionalizing the neurotropic rabies virus-derived polypeptide, RVG, and loading reduction-sensitive nanomicelles (polymer and doxorubicin) enable a highly specific and efficacious drug accumulation in the brain. Interestingly, curcumin serves as the hydrophobic core of the polymer, while suppressing the major efflux proteins in doxorubicin-resistant glioma cells. Studies on doxorubicin-resistant rat glioma cells demonstrate that the RVG-modified micelles exhibit superior cell entry and antitumor activity. In vivo research further showed that RVG modified nanomicelles significantly enhanced brain accumulation and tumor inhibition rate in mice, leading to a higher survival rate with negligible systemic toxicity. Moreover, effective suppression of recurrence and pulmonary metastatic nodules were also determined after the RVG-modified nanomicelles treatment. The potential of RVG-modified nanomicelles for glioma was demonstrated. Brain accumulation was markedly enhanced after i.v. administration. This unique drug delivery nanoplatform to the brain provides a novel and powerful therapeutic strategy for the treatment of central nervous system disorders including glioma. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Reference of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Active Targeting Nanoparticle Self-Assembled from Cisplatin-Palbociclib Amphiphiles Ensures Optimal Drug Ratio for Combinatorial Chemotherapy was written by Xiang, Yucheng;Liu, Chendong;Chen, Liqiang;Li, Lian;Huang, Yuan. And the article was included in Advanced Therapeutics (Weinheim, Germany) in 2021.Recommanded Product: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Triple neg. breast cancer (TNBC) not only exhibits aggressive progression and metastasis, but also responds to neither hormone therapy nor checkpoint blockade therapy. Thus, combinatorial chemotherapy is indispensable for TNBC treatment. However, due to the different pharmacokinetics of individual drugs and weak synergistic effects caused by random drug molar ratio in tumor, direct coadministration is far from satisfactory. Constructing a nanoscale drug delivery system with fixed drug molar ratios and maximum drug content is an urgent problem. Herein, an active targeting nanoparticle self-assembled from cisplatin-palbociclib amphiphiles with optimal drug ratio is reported. The combination of cisplatin and palbociclib at a molar ratio of 1:2 is found to have the best synergistic effect and is selected for follow-up studies. After conjugating two palbociclib mols. to one cisplatin mol., a fixed cisplatin/palbociclib (1:2) molar ratio is enabled and this amphiphilic conjugate can self-assemble into nanoparticles. A small amount of iRGD coupled 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol-2000 (DSPE-PEG-iRGD) that further stabilizes the nanoparticle is introduced to fabricate the desired nanoparticle (iRGD-PCN) and endow active tumor-targeting ability. On an orthotopic TNBC mouse model, iRGD-PCN efficiently accumulates in tumors and inhibits tumor growth. Addnl., the formation of lung metastasis nodes is also significantly suppressed. In general, the active targeting nanoparticles self-assembled from cisplatin-palbociclib amphiphiles provide options for combinatorial chemotherapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica