Category: 38215-36-0

Hypoxia-responsive immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy for potentiating cancer immunotherapy was written by Chen, Weiguo;Sheng, Ping;Chen, Yujiang;Liang, Yi;Wu, Sixin;Jia, Liying;He, Xin;Zhang, Chunfeng;Wang, Chongzhi;Yuan, Chunsu. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2023.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Inducing cell death while simultaneously enhancing antitumor immune responses is a promising therapeutic approach for multiple cancers. Celastrol (Cel) and 7-ethyl-10-hydroxycamptothecin (SN38) have contrasting physicochem. properties, but strong synergy in immunogenic cell death induction and anticancer activity. Herein, a hypoxia-sensitive nanosystem (CS@TAP) was designed to demonstrate effective immunotherapy for colorectal cancer by systemic delivery of an immunostimulatory chemotherapeutic combination. Furthermore, the combination of CS@TAP with anti-PD-L1 mAb (αPD-L1) exhibited a significant therapeutic benefit of delaying tumor growth and increased local doses of immunogenic signaling and T-cell infiltration, ultimately extending survival. We conclude that CS@TAP is an effective inducer of immunogenic cell death (ICD) in cancer immunotherapy. Therefore, this study provides an encouraging strategy to synergistically induce immunogenic cell death to enhance tumor cytotoxic T lymphocytes (CTLs) infiltration for anticancer immunotherapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application In Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thermo/glutathione-sensitive release kinetics of heterogeneous magnetic micro-organogel prepared by sono-catalysis was written by Dong, Jun;Du, Xiaoyu;Zhang, Yongqiang;Zhuang, Tingting;Cui, Xuejun;Li, Zhanfeng. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.Electric Literature of C20H18N2O2S The following contents are mentioned in the article:

To improve the loading and delivery for hydrophobic drugs and optimize the release efficiency in tumor microenvironment, a novel core-shell magnetic micro-organogel carrier was successfully prepared by a sono-catalysis process in the study. As-synthesized magnetic micro-organogel had an appropriate dispersibility in water owing to the hydrophilicity of protein shell and could be kept steadily with a well-defined spherical morphol. owing to the three-dimensional gel structure of oil core, and it promised an accessible targeted drug delivery owing to its good magnetism-mediated motion ability. Moreover, the magnetic micro-organogel showed a high loading efficiency up to 94.22% for coumarin 6 which was dissolved into the micro-organogel as a model hydrophobic drug. More importantly, the release kinetics revealed that the magnetic micro-organogel had a thermo-sensitive and glutathione (GSH)-sensitive ability to control the drug release, and proved that its release mechanisms referred to the combination of erosion, diffusion and degradation This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Electric Literature of C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Preparation and evaluation of SN-38-loaded MMP-2-responsive polymer micelles was written by He, Xiuting;Cao, Zhongcheng;Li, Nuannuan;Chu, Liuxiang;Wang, Jiazhen;Zhang, Chunyan;He, Xiaoyan;Lu, Xiaoyan;Sun, Kaoxiang;Meng, Qingguo. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Reference of 38215-36-0 The following contents are mentioned in the article:

7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded polyethylene glycol-GPLGVRG-poly β-benzyl-L-aspartic acid (PEG-GPLGVRG-PBLA) self-assemblies were successfully prepared using a classical nanopptn. method to give an enzyme-responsive nano-drug delivery system. The PEG-GPLGVRG-PBLA/SN-38 self-assemblies were characterized by transmission electron microscopy, dynamic light scattering, and high-performance liquid chromatog. The encapsulation efficiency was 91.7 ± 1.21% and the drug loading was 16.6 ± 0.93%. The 12 h in vitro release of SN-38 from PEG-GPLGVRG-PBLA/SN-38 treated with MMP-2 was 73.2 ± 2.05%, which was significantly higher than that for the group without MMP-2, demonstrating the enzyme-responsiveness of the nano-drug delivery system. In addition, the cellular uptake and tumor accumulation of PEG-GPLGVRG-PBLA were better than those of PEG-PBLA, and the blank PEG-GPLGVRG-PBLA showed high biocompatibility. These findings indicate that the enzyme-responsive nano SN-38 delivery system could provide new opportunities in tumor therapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Reference of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Amide-Linked Dendron-based Amphiphiles: A class of pH sensitive and highly biocompatible drug carrier for sustained drug release was written by Kumar, Ashwani;Singh, Mamta;Panda, Amulya Kumar;Tyagi, Yogesh Kumar. And the article was included in Supramolecular Chemistry in 2021.HPLC of Formula: 38215-36-0 The following contents are mentioned in the article:

PG-dendritic amide-linked amphiphilic micelles were studied to increase the solubility of hydrophobic mols. The encapsulation study was done by utilizing hydrophobic pyrene dye using U.V. technique. The encapsulation efficiency of the non-ionic amphiphiles was obtained at neutral p.H. and at room temperature (p.H. 7.0 & 28 °C). The G.3 dendron-based non-ionic oleic (C₁₈-cis)-amphiphile was found to have the 78.2% encapsulation efficiency. Studies show that the amide-linked G.1 dendron-based non-ionic (C₁₈-cis) amphiphiles have sustained dye release percentage of 78.00% at p.H. 6.2 and 26.19% at p.H. 7.0 in 72 h at 37 °C. The in vitro cyto-toxicol. studies showed that after 24-48 h treatment, the G.1 amide amphiphiles exhibit more than 80% of cell viability for concentration as high as 31.25 μg/mL. The cellular uptake was demonstrated using Coumarin 6. The integrated amphiphiles are biocompatible and can be used in the biomedical field as medication encapsulation and target drug delivery. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0HPLC of Formula: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Surface-modified polylactic acid nanospheres with chitosan for antibacterial activity of 1, 2-benzisothiazolin-3-one was written by Yao, Junwei;Liu, Jingxia;Zhi, Heng;Tao, Hongbing;Xie, Xiaobao;Shi, Qingshan. And the article was included in Carbohydrate Polymers in 2021.HPLC of Formula: 38215-36-0 The following contents are mentioned in the article:

The primary purpose of this study was to develop an innovative chitosan (CS) modified polylactic acid (PLA) nanospheres for enhancing the bioavailability of 1, 2-benzisothiazolin-3-one (BIT). The cellular uptake efficiency was corresponded pos. to the quantity of CS coated on BIT-PLA nanospheres against E. coli and S. aureus. The membrane potentials of E.coli and S. aureus treated with BIT-PLA, BIT-PLA-0.1%CS and BIT-PLA-0.5%CS were reduced with the extension of incubation time and the ratio of coated CS. The enhancement of CS modified on BIT-PLA nanospheres was reduced antioxidase activities and generated excessive reactive oxygen species. The lowest EC50 value of the modified BIT-PLA-0.5%CS suggested that its toxicity index was around 2.95-fold and 2.11-fold that of non-modified BIT-PLA against E. coli and S. aureus, resp. These results revealed that the CS modified BIT-PLA nanospheres had a bright prospect in antibacterial formulation delivery system and improving the bioavailability. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0HPLC of Formula: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye was written by Xu, Chen;Lu, Jinhui;Zhou, Li;Liang, Jie;Fang, Lei;Cao, Feng. And the article was included in Carbohydrate Polymers in 2021.Reference of 38215-36-0 The following contents are mentioned in the article:

Topical drug delivery system to the posterior segment of the eye is facing many challenges, such as rapid drug elimination, low permeability, and low concentration at the targeted sites. To overcome these challenges, Multifunctional nanocomposite eye drops of dexamethasone-carboxymethyl-β-cyclodextrin@layered double hydroxides-glycylsarcosine (DEX-CM-β-CD@LDH-GS) were developed for relay drug delivery. Herein, our studies demonstrated that DEX-CM-β-CD@LDH-GS could penetrate through human conjunctival epithelial cells with an intact structure and exhibited integrity in the sclera of rabbits eyes with in vivo fluorescence resonance energy transfer imaging. Consequently, tissue distribution indicated that DEX-CM-β-CD@LDH-GS nanocomposite eye drops could maintain the effective therapeutic concentration of DEX in choroid-retina within 3 h. As a relay drug delivery system, drug-CD@LDH nanocomposites offer an efficient strategy for drug delivery from ocular surface to the posterior segment. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Reference of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Reference of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shedding light on predicting and controlling emission chromaticity in multicomponent photoluminescent systems was written by Price, J.;Balonova, B.;Blight, B. A.;Eisler, S.. And the article was included in Chemical Science in 2021.Category: thiazole The following contents are mentioned in the article:

Predictable color tuning in multicomponent photoluminescent (PL) systems is achieved using mixtures of simultaneously emitting organic mols. By mitigating the potential for energy transfer through the control of concentration, the resulting emission chromaticity of five dichromic PL systems is approximated as a linear combination of the emitting components and their corresponding brightness (χ_i, φ_i, and I_ex,i). Despite being limited to dilute solutions (10^-6 M), color tuning within these systems was controlled by (1) varying the composition of the components and (2) exploiting the differences in the components’ excitation intensities at common wavelengths. Using this approach, white light emission (WLE) was realized using a pre-determined mixture of red, green, and blue emitting organic mols. Based on these results, materials and devices with built-in or programmable emission color can be achieved, including highly sought-after WLE. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Category: thiazole).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Exploration of a simplified protocol for solid lipid nanoparticles production and characterization was written by Loureiro, Joana A.;Pereira, Maria C.. And the article was included in Journal of Chemical Education in 2021.Computed Properties of C20H18N2O2S The following contents are mentioned in the article:

Solid Lipid Nanoparticles (SLNs) are exciting nanoparticles used for transport therapeutic drugs into the organism. In this laboratory work, a simple experiment is performed to introduce master students into the field of nanotechnol., here applied to health including the applications in healthcare/pharmaceutical and cosmetic industry. This work demonstrates the advantages of SLNs as a vehicle to deliver/transport hydrophobic mols. The experiments are designed to be accomplished in two parts, i.e. two practical classes of 120 min each. In the first part, students will produce SLNs using homogenization followed by the ultrasonication method. In the second part, the SLNs will be characterized through their hydrodynamic size, polydispersity index, zeta potential and microscopically observed using a fluorescence microscope. Their encapsulation efficiency (EE) and loading capacity (LC) will be calculated This laboratory work could be performed in groups of two students. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Computed Properties of C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety was written by Kuang, Xiao;Chi, Dongxu;Li, Jinbo;Guo, Chunlin;Yang, Yinxian;Zhou, Shuang;Luo, Cong;Liu, Hongzhuo;He, Zhonggui;Wang, Yongjun. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.COA of Formula: C20H18N2O2S The following contents are mentioned in the article:

The platinum-based drugs prevail in the therapy of malignant tumors treatment. However, their clin. outcomes have been heavily restricted by severe systemic toxicities. To ensure biosafety and efficiency, herein, we constructed a disulfide bond inserted Pt(IV) self-assembled nanoplatform that is selectively activated by rich glutathione (GSH) in tumor site. Disulfide bond was introduced into the conjugates of oxaliplatin (IV) and oleic acid (OA) which conferred cascade reduction-responsiveness to nanoassemblies. Disulfide bond cleavage and reduction of Pt(IV) center occur sequentially as a cascade process. In comparison to oxaliplatin solution, Pt(IV) nanoparticles (NPs) achieved prolonged blood circulation and higher maximum tolerated doses. Furthermore, Oxa(IV)-SS-OA prodrug NPs exhibited potent anti-tumor efficiency against 4T1 cells and low toxicities in other normal tissues, which offers a promising nano-platform for potential clin. application. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0COA of Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.COA of Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Molecular dynamics simulation of perforation of graphene under impact by fullerene projectiles was written by Zhang, Yang;Qiu, Yun;Niu, Fuzhou;Ademiloye, A. S.. And the article was included in Materials Today Communications in 2022.Related Products of 38215-36-0 The following contents are mentioned in the article:

In this paper, mol. dynamics (MD) simulations are employed to study the perforation of graphene under impact by fullerenes of various sizes. The buckling characteristics of fullerenes after impact are classified and discussed. The relative state of C₁₈₀ projectile and graphene under impact at different velocities is also investigated. We observed that the C180 projectile rebounds at low velocity (V < 4.25 km/s), sticks to graphene at high velocity (4.25 km/s ≤V ≤ 4.75 km/s), and perforates the graphene at higher velocity (V ≥ 4.75 km/s). It is found that the buckled cap of large-size fullerene formed after impact can better absorb kinetic energy. In addition, different crack modes of graphene after perforation were investigated. The effect of fullerene projectile size and initial velocity on ballistic limit velocity was also clarified. This study provides new implications for the application of large-size fullerenes as impact shields. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Related Products of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Related Products of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica