Category: 38215-36-0

Preparation of fluorescent conjugated polymer micelles with multi-color emission for latent fingerprint imaging was written by Wang, Jun;Peng, Rui;Luo, Yufeng;Wu, Qing;Cui, Qianling. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021.Formula: C20H18N2O2S The following contents are mentioned in the article:

The development of novel imaging agents for fluorescence detection of latent fingerprint is still important for criminal investigation and identity recognition. Herein, we reported a simple and robust method to prepare multi-color conjugated polymer micelles for visualization of fingerprints. A conjugated polyelectrolyte, poly[(9,9-bis(3′-((N,N-dimethyl)-N-ethylammonium)-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)] (PFN), was dissolved in water forming polymer micelles with blue emission. Green and red emissions were facilely achieved by incorporating small organic fluorophores including coumarin 6 (C6) and Nile red (NR) into the PFN micelles, resp. These micelles exhibited bright fluorescence both in solution and solid film, where significant aggregation-caused quenching was avoided and fluorescence resonance energy transfer from PFN to C6 or NR was enhanced. Through a simple solution method, these polymer micelles proved their high affinity towards the fingerprint ridges. Accordingly, fluorescent fingerprint images with high-resolution were obtained, which were less interfered by fluorescence background from substrate and overlap between adjacent fingerprints. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chemical-Resistant Green Luminescent Concentrator-Based Photo-Microreactor via One-Touch Assembly of 3D-Printed Modules was written by Ahn, Gwang-Noh;Kim, Mi-Jeong;Yim, Se-Jun;Sharma, Brijesh M.;Kim, Dong-Pyo. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Synthetic Route of C20H18N2O2S The following contents are mentioned in the article:

The direct use of the most sustainable energy, the sun, for chem. reactions is extremely attractive. This study proposes a green luminescent concentrator-based photo-microreactor (GLC-PM) assembled by flow modules that can be diversely 3D-printed using a photocurable fluoropolymer formulated with a fluorescent dye (Coumarin 6) for enhancing photochem. reactions. The inherently solvent-resistant GLC-flow modules maintain the chem. efficiency without leaching of fluorescent dyes and deposition of photocatalyst on the walls. In particular, the hexagonal GLC modules enable facile assembly into the customized PMs based on the synthesis requirements using built-in magnets for one-touch self-alignment. Moreover, the serially assembled GLC-PM was shown to enhance the photocatalytic reaction of C-C bond formation in the presence of Rose Bengal, and eventually, the GLC-PM formed by clustering serial and radial connections resulted in enhanced conversion and throughput of C-P bond formation in the presence of Eosin-Y. Therefore, the clustered GLC-PM can be considered as a viable and unique scaling strategy for the production of organic compounds, such as a photo-driven mini-plant. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Synthetic Route of C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Synthetic Route of C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alginate-Based Amphiphilic Block Copolymers as a Drug Codelivery Platform was written by Feng, Yunpeng;Quinnell, Sean P.;Lanzi, Alison M.;Vegas, Arturo J.. And the article was included in Nano Letters in 2021.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Structured nanoassemblies are biomimetic structures that are enabling applications from nanomedicine to catalysis. One approach to achieve these spatially organized architectures is utilizing amphiphilic diblock copolymers with one or two macromol. backbones that self-assemble in solution To date, the impact of alternating backbone architectures on self-assembly and drug delivery is still an area of active research limited by the strategies used to synthesize these multiblock polymers. Here, we report self-assembling ABC-type alginate-based triblock copolymers with the backbones of three distinct biomaterials utilizing a facile conjugation approach. This “polymer mosaic” was synthesized by the covalent attachment of alginate with a PLA/PEG diblock copolymer. The combination of alginate, PEG, and PLA domains resulted in an amphiphilic copolymer that self-assembles into nanoparticles with a unique morphol. of alginate domain compartmentalization. These particles serve as a versatile platform for co-encapsulation of hydrophilic and hydrophobic small mols., their spatiotemporal release, and show potential as a drug delivery system for combination therapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A dual-functional supramolecular assembly for enhanced photocatalytic hydrogen evolution was written by Qin, Lin;Wang, Ruijie;Xin, Xing;Zhang, Mo;Liu, Tianfu;Lv, Hongjin;Yang, Guo-Yu. And the article was included in Applied Catalysis, B: Environmental in 2022.SDS of cas: 38215-36-0 The following contents are mentioned in the article:

The construction of multifunctional supramol. assembly is a central research interest in solar-driven water splitting to hydrogen. We here report the successful preparation of a dual-functional supramol. assembly via facile electrostatic integration of a pos.-charged Ir-based chromophore and a neg.-charged nickel-substituted polyoxometalate catalyst. The resulting dual-functional supramol. can form ordered vesicle-like assemblies and work efficiently as both light-absorber and catalyst for hydrogen production under visible light irradiation Under minimally optimized conditions, a catalytic hydrogen production turnover number of over 4000 was achieved after 96-h irradiation, which is 17 times to that of discrete components under otherwise identical conditions. Destruction of such ordered vesicle-like assemblies will lead to a remarkable decrease of photocatalytic hydrogen production activity. Mechanistic studies further revealed the presence of both oxidative and reductive quenching processes during photocatalysis and also confirmed that the formation of ordered supramol. is beneficial for effective electron transfer between chromophore and catalyst. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0SDS of cas: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.SDS of cas: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis was written by Deng, Caifeng;Zhang, Quan;He, Penghui;Zhou, Bin;He, Ke;Sun, Xun;Lei, Guanghua;Gong, Tao;Zhang, Zhirong. And the article was included in Nature Communications in 2021.SDS of cas: 38215-36-0 The following contents are mentioned in the article:

Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid arthritis (RA) joints contributes toward the persistent progression of joint inflammation and destruction. Here, we deliver celastrol (CEL) to selectively induce apoptosis of OCs and macrophages in arthritic joints, with enzyme-responsive nanoparticles (termed PRNPs) composed of RGD modified nanoparticles (termed RNPs) covered with cleavable PEG chains. CEL-loaded PRNPs (CEL-PRNPs) dually target OCs and inflammatory macrophages derived from patients with RA via an RGD-αvβ3 integrin interaction after PEG cleavage by matrix metalloprotease 9, leading to increased apoptosis of these cells. In an adjuvant-induced arthritis rat model, PRNPs have an arthritic joint-specific distribution and CEL-PRNPs efficiently reduce the number of OCs and inflammatory macrophages within these joints. Addnl., rats with advanced arthritis go into inflammatory remission with bone erosion repair and negligible side effects after CEL-PRNPs treatment. These findings indicate potential for targeting chemotherapy-induced apoptosis in the treatment of advanced inflammatory arthritis. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0SDS of cas: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.SDS of cas: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment was written by Qian, Yun;Zhang, Jun;Xu, Rui;Li, Qiang;Shen, Qi;Zhu, Guofu. And the article was included in International Journal of Biological Macromolecules in 2021.Computed Properties of C20H18N2O2S The following contents are mentioned in the article:

Triple neg. breast cancer (TNBC) metastasis is still one of the obstacles in clin. treatment, while highly-effective cancer drugs usually cannot be used for their hydrophobicity and comprehensive system toxicity. This study built a kind of pH-sensitive nanoparticles (PP/H NPs) constructed by poly (lactic-co-glycolic acid) modified with β-cyclodextrin (PLGA-β-CD), polyethyleneimine grafted with benzimidazole (PEI-BM) and low mol. weight heparin (LMWH) to delivery Celastrol (Cela) and ferrocene (Fc) for breast cancer therapy. PLGA-β-CD and PEI-BM were synthesized by amidation reaction, the amphipathic polymer nanoparticles with 108.37 ± 1.02 nm were self-assembled in water. After PP/H NPs treatment, the half maximal inhibitory concentration (IC₅₀) decreased by 91% compared with Cela, and ROS level was also elevated. PP/H NPs led to substantial tumor inhibiting rate (TIR, 65.86%), utilized LMWH to strengthen the anti-metastasis effect of PP/H NPs. PP/H NPs took advantage of exogenous chemotherapeutics and endogenous ROS to inhibit tumor growth, and combined with LMWH to hinder breast cancer metastasis. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Computed Properties of C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Computed Properties of C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A Hypoxia-Sensitive Drug Delivery System Constructed by Nitroimidazole and its Application in the Treatment of Hepatocellular Carcinoma was written by Meng, Tingting;Li, Yinghong;Tian, Ying;Ma, Mingxing;Shi, Kequan;Shang, Xuwei;Yuan, Hong;Hu, Fuqiang. And the article was included in AAPS PharmSciTech in 2022.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Hypoxia is an important pathol. phenomenon, and it can induce many tumor microenvironment changes, such as accumulations of intracellular lactic acid, decrease of tumor microenvironment pH value, and regulate a series of physiol. and pathol. processes such as adhesion, metastasis, and immune escape. Hypoxic tumor cells act as a key target for treating tumor. In this research, we designed and prepared PEG-nitroimidazole grafts, PEG-NI, and FA-PEG-NI. We first explored their phys. and chem. properties to serve as a drug carrier. Then, the hypoxia-sensitive properties such as particle size changes and drug release were investigated. Finally, the tumor targeting ability was studied in vitro and in vivo, and anti-tumor capacity was determined Both grafts showed excellent property as a nanodrug carrier and showed favorable drug encapsulation ability of sorafenib with the help of the hydrophobic chain of 6-(BOC-amino) hexyl bromide. The micelles responded to the hypoxic tumor environment with chem. and spatial structure changes leading to sensitive and fast drug release. With the modification of folic acid, FA-PEG-NI gained tumor targeting ability in vivo. FA-PEG-NI graft proved a potential targeting drug delivery system in the treatment of hypoxic hepatocellular carcinoma. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Polymeric Lipid Hybrid Nanoparticles as a Delivery System Enhance the Antitumor Effect of Emodin in Vitro and in Vivo was written by Liu, Hui;Zhuang, Yong;Wang, Panpan;Zou, Tengteng;Lan, Meng;Li, Lihong;Liu, Fengjie;Cai, Tiange;Cai, Yu. And the article was included in Journal of Pharmaceutical Sciences in 2021.COA of Formula: C20H18N2O2S The following contents are mentioned in the article:

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphol., encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanopptn. method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. The efficacy of E-PLNs in tumor bearing nude mice has also been studied. The average particle size of the exptl. prepared E-PLNs was (122.7±1.79) nm, and the encapsulation rate was 72.8%. Compared with free Emodin (EMO), E-PLNs showed greater toxicity to MCF-7 cells by promoting the uptake of EMO, and can promote the early apoptosis of MCF-7 cells. In addition to the morphol. changes of apoptotic cells, the ratio of Bax/Bcl-2 was significantly increased, which indicated that E-PLNs can induce apoptosis in MCF-7 cells to achieve anticancer effect. Finally, E-PLNs significantly inhibited tumor growth by more than 60%, which may be related to its passive targeting effect on tumor site. Our results suggest that E-PLNs have shown good anti-breast cancer effect than free EMO. Moreover, the effect of E-PLNs on MCF-7 cells is mainly related to the induction of apoptosis. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0COA of Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.COA of Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles was written by Zhang, Hongyan;Li, Ji;Yuan, Rong;Li, Yufen;Zhang, Yue;Hu, Xiaoyun;Qu, Jiqiang;Chen, Yu;Wang, Zheran;Xia, Mingyu;Wang, Dongkai. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.Computed Properties of C20H18N2O2S The following contents are mentioned in the article:

Functionally-enabled delivery systems for aggressive lung metastases from breast cancer have been broadly examined, and the simultaneous inhibition of metastasis while fighting tumors persists as a provocative concern. We propose a valid strategy for delivering natural drugs-Honokiol (Hol) to achieve eradication of breast cancer cells and inhibition of pulmonary metastasis. A non-toxic degradable pH-sensitive polymer-PBAE for encapsulated Hol, and the outer layer was wrapped with Folate-DSPE-PEG2000 (FA/PBAE/Hol-NPs), which have strengthened stability, prolonged in vivo circulation time and efficiently targets tumor sites. FA/PBAE/Hol-NPs displayed dampening the capability of migration and invasion, elevated 4T1 uptake and boosted apoptosis. What′s more, 4T1 breast cancer model mice exhibited marked anti-tumor (Inhibition rate of 62.8%) and lung metastasis suppression (Inhibition rate of 84.3%). In parallel, histol. immunofluorescence and immunohistochem. assays demonstrate higher apoptosis levels and repression of matrix metalloproteinase expression in mice, all of which are instrumental in inhibiting lung metastasis. Taken together, FA/PBAE/Hol-NPs can as an efficacious i.v. drug delivery system for the curative treatment of metastatic breast cancer. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Computed Properties of C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Water-soluble hollow nanocrystals from self-assembly of AIEE-active Pt(II) metallomesogens was written by Cuerva, Cristian;Fernandez-Lodeiro, Javier;Cano, Mercedes;Capelo-Martinez, Jose Luis;Lodeiro, Carlos. And the article was included in Nano Research in 2021.Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Luminescent hollow micro- and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II) metallomesogens decorated with four terminal alkyl chains. Oil-in-water droplets have been used to confine the Pt(II) compounds and drive them to be self-assembled via intermol. Pt-Pt interactions into spherical aggregates of about 200 or 50 nm. Evaporation of the oil phase generates highly-stable aqueous dispersions of nanocrystals that emit a bright orange light as a result of the existence of 3MMLCT excited states. Different methods and conditions have been tested for studying the effect of several parameters such as the temperature and the stirring speed in the final particle size and in the polydispersity index. Moreover, the micro- and nanocrystals are able to entrap hydrophobic drugs between the alkyl chains of the compounds, forming stable dispersions of drug-loaded capsules in water. The droplet method is applied in the area of metallomesogens for the first time to synthesize self-assembled Pt(II) nanocapsules, which opens a new field of study that could allow the use of these liquid crystal materials in biomedical applications. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica