Category: 383865-57-4

Synthetic Route of 383865-57-4, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.383865-57-4, Name is 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine, molecular formula is C12H15N3O2S. In a patent, introducing its new discovery.

In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically improved metabolic stability. The N1-substituent on 2-oxo-1,2-dihydropyridine ring can be a variety of alkyl, aryl, and heteroaryl groups, but among them, 2-pyridyl provided much enhanced Caco-2 permeability, attributed to its ability to form intramolecular hydrogen bonds. Further structure-activity relationship studies at the C3 position led to the identification of highly potent and selective Tyk2 JH2 inhibitor 6, which proved to be highly effective in inhibiting IFNIgamma production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model.

In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically improved metabolic stability. The N1-substituent on 2-oxo-1,2-dihydropyridine ring can be a variety of alkyl, aryl, and heteroaryl groups, but among them, 2-pyridyl provided much enhanced Caco-2 permeability, attributed to its ability to form intramolecular hydrogen bonds. Further structure-activity relationship studies at the C3 position led to the identification of highly potent and selective Tyk2 JH2 inhibitor 6, which proved to be highly effective in inhibiting IFNIgamma production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model.

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Reference£º
Thiazole | C3H5305NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 383865-57-4, Name is 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine, molecular formula is C12H15N3O2S. In a Patent, authors is O’NEILL, David John£¬once mentioned of 383865-57-4, 383865-57-4

The present invention provides compounds, compositions thereof, and methods of using the same.

The present invention provides compounds, compositions thereof, and methods of using the same.

383865-57-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 383865-57-4 is helpful to your research.

Reference£º
Thiazole | C3H5293NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 4 (4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-carbamic acid isobutyl ester Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and isobutanol, the title compound was obtained as yellow crystals (12% yield). MS: m/e=366(M+H+), mp 164-168 C.

383865-57-4, The synthetic route of 383865-57-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235842; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-Oxo-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and piperidin-4-one the title compound was obtained as white solid (38%). MS: m/e=391 (M+H+).

383865-57-4, As the paragraph descriping shows that 383865-57-4 is playing an increasingly important role.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

383865-57-4, 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-urea Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and benzylamine the title compound was obtained as an off-white solid (99%), MS: m/e=399 (M+H+).

383865-57-4, 383865-57-4 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine 11402861, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica