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The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs esters and metabolites thereof. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.

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Reference:
Thiazole | C3H9164NS – PubChem,
Thiazole | chemical compound | Britannica

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A novel and efficient synthesis of 5-(hydroxymethyl)thiazole, an important synthon for the preparation of biologically active compounds, is described. The research also provides additional insight into the properties of halothiazoles.

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Reference:
Thiazole | C3H9212NS – PubChem,
Thiazole | chemical compound | Britannica

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A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.

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Reference:
Thiazole | C3H9216NS – PubChem,
Thiazole | chemical compound | Britannica

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The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

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Reference:
Thiazole | C3H9155NS – PubChem,
Thiazole | chemical compound | Britannica

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A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention.

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Reference:
Thiazole | C3H9213NS – PubChem,
Thiazole | chemical compound | Britannica

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IMIDAZOPYRIDINE COMPOUNDS

[Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having a carbamoyl group at the 3-position and a particular cyclic group at the 8-position via a methyleneoxy group, or a salt thereof have sGC activation, and are useful as active ingredients of pharmaceutical compositions for treating or preventing various sGC-related cardiovascular diseases, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension, thereby completing the present invention.

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Reference:
Thiazole | C3H9219NS – PubChem,
Thiazole | chemical compound | Britannica

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RETROVIRAL PROTEASE INHIBITING PIPERAZINE COMPOUNDS

Retroviral protease inhibiting compounds of the formula: STR1 are disclosed.

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Reference:
Thiazole | C3H9184NS – PubChem,
Thiazole | chemical compound | Britannica

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PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors o f protein kinase of formula 1 and process for their production and pharmaceutical compositions thereof. In particular, the present invention relates to inhibitors of the members of the Tec, Src and Btk protein kinase families

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Reference:
Thiazole | C3H9158NS – PubChem,
Thiazole | chemical compound | Britannica

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 38585-74-9, Name is Thiazol-5-ylmethanol, molecular formula is C4H5NOS. In a Patent£¬once mentioned of 38585-74-9, SDS of cas: 38585-74-9

In the molecule by of Ritonavir selenazole link into a thiazole ring, a thiazole ring substituent and modify the structure, we have obtained some has good anti-HIV – 1 biological activity of Ritonavir selenazole analogs. Characterized in that the method comprises the following steps: In formula I, X=O, S or Se; Y=N, CH; R1 =H, alkyl, aromatic; R2 =H, alkyl, aromatic. (by machine translation)

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Reference£º
Thiazole | C3H9191NS – PubChem,
Thiazole | chemical compound | Britannica

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Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N’-methyl-N”-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. ”

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N’-methyl-N”-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. ”

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Reference£º
Thiazole | C3H9187NS – PubChem,
Thiazole | chemical compound | Britannica