Category: 38923-13-6

Synthetic Route of 38923-13-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 38923-13-6, C5H4BrNOS. A document type is Article, introducing its new discovery.

MK-4256, a tetrahydro-beta-carboline sstr3 antagonist, was discontinued due to a cardiovascular (CV) adverse effect observed in dogs. Additional investigations revealed that the CV liability (QTc prolongation) was caused by the hERG off-target activity of MK-4256 and was not due to sstr3 antagonism. In this Letter, we describe our extensive SAR effort at the C3 position of the tetrahydro-beta-carboline structure. This effort resulted in identification of 5-fluoro-pyridin-2-yl as the optimal substituent on the imidazole ring to balance sstr3 activity and the hERG off-target liability.

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Reference：
Thiazole | C3H2401NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 38923-13-6, Name is 2-Bromo-1-(thiazol-4-yl)ethanone,molecular formula is C5H4BrNOS, is a conventional compound. this article was the specific content is as follows.name: 2-Bromo-1-(thiazol-4-yl)ethanone

Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.

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Reference：
Thiazole | C3H2400NS – PubChem,
Thiazole | chemical compound | Britannica