Category: 39136-60-2

39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5-ethylthiazol-2-amine (5) (0.13 g, 1.0 mmol), 2-(4-nitrophenyl)-acetonitrile (6) (0.18 g, 1.1 mmol), 3-nitrobenzaldehyde (8a)(0.17 g, 1.1 mmol), SiO2-ZnBr2 (0.10 g), and diisopropylethylamine (DIPEA) (0.033 g, 0.25 mmol) was taken into a microwave glass vial containing EtOH (4 ml). The glass vial was placed in the cavity of microwave oven (465 W power) and irradiated for 4 min at 70C and then cooled to 27C after completion of the reaction (TLC). EtOH (5 ml) was added to the reaction mixture, and then it was filtered to recover the catalyst. The organic layer was concentrated under vacuum to obtain the crude product which was purified by column chromatography using CH2Cl2-MeOH in the ratio of 99.5:0.5 to 97.0:3.0, adjusted to the elution rate of the individual product, as mobile phase. Yield 0.41 g (96%), pale-yellow solid. IR spectrum, nu, cm-1: 3392 (N-H), 2984 (C-H), 1615 (C=N), 1552 (C=C), 1505 (NO2), 1340(NO2). 1H NMR spectrum, delta, ppm (J, Hz): 1.16 (3H, t,J = 7.6, CH3); 2.75 (2H, q, J = 7.6, CH2); 5.26 (2H, s,NH2); 6.18 (1H, s, 5-CH); 7.21 (1H, s, H-3); 7.69-8.01(5H, m, H Ar); 8.18 (1H, s, H Ar); 8.26 (2H, d, J = 6.8,H Ar). 13C NMR spectrum, delta, ppm: 13.5; 35.7; 53.2; 110.9;114.8; 121.9; 122.6; 125.3; 128.7; 130.3; 132.1; 136.5;140.6; 145.2; 147.0; 148.4; 149.8; 169.2. Mass spectrum,m/z (Irel, %): 424 [M+H]+ (100), 349 (21). Found, m/z:424.1056 [M+H]+. C20H18N5O4S. Calculated, m/z: 424.1074.

39136-60-2, 39136-60-2 5-Ethylthiazol-2-amine 12737257, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Devineni, Subba Rao; Madduri, Thirupal Reddy; Chamarthi, Naga Raju; Liu, Cong-Qiang; Pavuluri, Chandra Mouli; Chemistry of Heterocyclic Compounds; vol. 55; 3; (2019); p. 266 – 274; Khim. Geterotsikl. Soedin.; vol. 55; 3; (2019); p. 266 – 274,9;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: These compounds were prepared by adapting a published procedure.2 To a mixture of 2, 4, 7a-n,7p and acid chloride (1.1 equiv.) in THF (20 mL) was added triethylamine (3 equiv.). The reaction mixture was stirred at room temperature for 15 min and quenched with distilled water. Following addition of a 0.1 N HCl aqueous solution, the product was extracted with DCM. The organic phase was washed with a saturated aqueous solution of NaHCO3, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography

39136-60-2, As the paragraph descriping shows that 39136-60-2 is playing an increasingly important role.

Reference£º
Article; Ishita, Keisuke; Stefanopoulos, Stavros; Khalil, Ahmed; Cheng, Xiaolin; Tjarks, Werner; Rappleye, Chad A.; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2251 – 2261;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica