Category: 39736-29-3

39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, molecular formula is C7H10N2O2S2, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 39736-29-3, name: Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

The invention belongs to the technical field of pharmaceutical intermediates, relates to a 4 – amino-thiazole – 5 – carboxylic acid ethyl ester synthesis method, steps which consists in: the 4 – amino – 2 – (methylthio) thiazole – 5 – carboxylic acid ethyl ester dissolved in ethanol, adding concentrated hydrochloric acid, adding zinc powder batches under stirring, reflux reaction for 4 hours, to obtain the neutralizing liquid; to the neutralizing liquid is filtered, the filter cake washing with ethanol for 2 – 3 times, the filtrate concentrated under reduced pressure, to obtain the concentrated solution; adding the concentrated in methylene chloride and water, stirring, separating the organic phase; the organic phase with saturated sodium chloride solution for washing, drying with anhydrous sodium sulfate, concentrated, isopropyl alcohol recrystallize to get 4 – amino thiazole – 5 – carboxylic acid ethyl ester. The invention also provides a method for removing from a thio group on the aromatic ring of the new method, the raw materials are low cost, high yield, and suitable for production. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. In my other articles, you can also check out more blogs about 39736-29-3

Reference：
Thiazole | C3H8229NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, molecular formula is C7H10N2O2S2. In a Patent，once mentioned of 39736-29-3, category: thiazole

Compounds are disclosed having the formula: STR1 wherein the substituents are defined herein. The compounds of the invention are angiotensin II receptor antagonists.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: thiazole, you can also check out more blogs about39736-29-3

Reference：
Thiazole | C3H8238NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate,molecular formula is C7H10N2O2S2, is a conventional compound. this article was the specific content is as follows.name: Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

N-Chloroacetylanthranilic acid ethyl ester reacts with potassium thiocyanate in the presence of alcohol to give the (4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ester (3a). In the presence of water or amines the acetic acid derivative (3b) or the acetamide derivatives (3c,d) are obtained. 2-Amino-4-oxo-3,4-dihydroquinazolines (4) arise if vigorous reaction conditions are employed. Analogously, N-chloroacetyl derivatives of 5-membered heterocycles with enaminocarbonyl structure (5, 7, 9, 11, 13, 20, 23) react with potassium thiocyanate to yield thieno[2,3-d]-, thieno[3,2-d]-, imidazo[4,5-d]-, pyrrolo[3,2-d]-, and thiazolo[4,5-d]pyrimidines (6, 8, 10, 12, 14, 21, 24). Quinazolines (18, 19) are formed from the reaction of 2-chloroacetylaminoacetophenone (16a) and 2-chloroacetylaminobenzophenone (16b) with potassium thiocyanate and subsequent treatment of the intermediates with amines.

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Reference：
Thiazole | C3H8235NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 39736-29-3, C7H10N2O2S2. A document type is Article, introducing its new discovery., Application In Synthesis of Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

It has been hypothesized that aquaporin-9 (AQP9) is part of the unknown route of hepatocyte glycerol uptake. In a previous study, leptin receptor-deficient wild-type mice became diabetic and suffered from fasting hyperglycemia whereas isogenic AQP9-/- knock-out mice remained normoglycemic. The reason for this improvement in AQP9-/- mice was not established before. Here, we show increased glucose output (by 123%±36% S.E.) in primary hepatocyte culture when 0.5 mM extracellular glycerol was added. This increase depended on AQP9 because it was absent in AQP9-/- cells. Likewise, the increase was abolished by 25 muM HTS13286 (IC50 ? 2 muM), a novel AQP9 inhibitor, which we identified in a small molecule library screen. Similarly, AQP9 deletion or chemical inhibition eliminated glycerol-enhanced glucose output in perfused liver preparations. The following control experiments suggested inhibitor specificity to AQP9: (i) HTS13286 affected solute permeability in cell lines expressing AQP9, but not in cell lines expressing AQPs 3, 7, or 8. (ii) HTS13286 did not influence lactate- and pyruvate-dependent hepatocyte glucose output. (iii) HTS13286 did not affect glycerol kinase activity. Our experiments establish AQP9 as the primary route of hepatocyte glycerol uptake for gluconeogenesis and thereby explain the previously observed, alleviated diabetes in leptin receptor-deficient AQP9-/- mice.

Interested yet? Keep reading other articles of 39736-29-3!, Application In Synthesis of Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

Reference：
Thiazole | C3H8236NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 39736-29-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, molecular formula is C7H10N2O2S2. In a Article£¬once mentioned of 39736-29-3

The 2-alkylthio-4-aminothiazoles 1a-k are converted into thiazolo<4,5-d>pyrimidines 2a-f, 3, 5, 7a, and 7b.Compound 1a reacts with formamide to give 2a after two hours at 200 deg C, but after eight hours at 200 deg C 3 is the resulting product.Reactions of 1b-e with formic acid and of 1f with formic acid and water give 2a and 2c-e, whereas 2b and 2f are obtained from 1b and 1e and acetylacetone. 1f reacts with formamide to yield the expected 5.Heating of 1g, 1h, 1j, and 1k with formamide affords the 2-aminothiazolo<4,5-d>pyrimidines 7a and 7b under substitution of the alkylthio by the amino group. 2a and 2b yield with phosphoryl chloride 4a and 4b.

The 2-alkylthio-4-aminothiazoles 1a-k are converted into thiazolo<4,5-d>pyrimidines 2a-f, 3, 5, 7a, and 7b.Compound 1a reacts with formamide to give 2a after two hours at 200 deg C, but after eight hours at 200 deg C 3 is the resulting product.Reactions of 1b-e with formic acid and of 1f with formic acid and water give 2a and 2c-e, whereas 2b and 2f are obtained from 1b and 1e and acetylacetone. 1f reacts with formamide to yield the expected 5.Heating of 1g, 1h, 1j, and 1k with formamide affords the 2-aminothiazolo<4,5-d>pyrimidines 7a and 7b under substitution of the alkylthio by the amino group. 2a and 2b yield with phosphoryl chloride 4a and 4b.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 39736-29-3 is helpful to your research., Reference of 39736-29-3

Reference£º
Thiazole | C3H8232NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 39736-29-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, molecular formula is C7H10N2O2S2. In a Article£¬once mentioned of 39736-29-3

The 2-alkylthio-4-aminothiazoles 1a-k are converted into thiazolo<4,5-d>pyrimidines 2a-f, 3, 5, 7a, and 7b.Compound 1a reacts with formamide to give 2a after two hours at 200 deg C, but after eight hours at 200 deg C 3 is the resulting product.Reactions of 1b-e with formic acid and of 1f with formic acid and water give 2a and 2c-e, whereas 2b and 2f are obtained from 1b and 1e and acetylacetone. 1f reacts with formamide to yield the expected 5.Heating of 1g, 1h, 1j, and 1k with formamide affords the 2-aminothiazolo<4,5-d>pyrimidines 7a and 7b under substitution of the alkylthio by the amino group. 2a and 2b yield with phosphoryl chloride 4a and 4b.

The 2-alkylthio-4-aminothiazoles 1a-k are converted into thiazolo<4,5-d>pyrimidines 2a-f, 3, 5, 7a, and 7b.Compound 1a reacts with formamide to give 2a after two hours at 200 deg C, but after eight hours at 200 deg C 3 is the resulting product.Reactions of 1b-e with formic acid and of 1f with formic acid and water give 2a and 2c-e, whereas 2b and 2f are obtained from 1b and 1e and acetylacetone. 1f reacts with formamide to yield the expected 5.Heating of 1g, 1h, 1j, and 1k with formamide affords the 2-aminothiazolo<4,5-d>pyrimidines 7a and 7b under substitution of the alkylthio by the amino group. 2a and 2b yield with phosphoryl chloride 4a and 4b.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 39736-29-3 is helpful to your research., Application of 39736-29-3

Reference£º
Thiazole | C3H8232NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, molecular formula is C7H10N2O2S2. In a Article£¬once mentioned of 39736-29-3, Application In Synthesis of Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

A variety of partly novel tri- and tetracyclic hetero systems were obtained by reaction of heteroaromatic 2-aminoesters with 2-(methylthio)-2-thiazoline, yielding double-annelation of a thiazolo[2,3-b]pyrimido moiety in a one-pot process.

A variety of partly novel tri- and tetracyclic hetero systems were obtained by reaction of heteroaromatic 2-aminoesters with 2-(methylthio)-2-thiazoline, yielding double-annelation of a thiazolo[2,3-b]pyrimido moiety in a one-pot process.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate, you can also check out more blogs about39736-29-3

Reference£º
Thiazole | C3H8240NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 39736-29-3, Name is Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate,molecular formula is C7H10N2O2S2, is a conventional compound. this article was the specific content is as follows.Recommanded Product: Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: Ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. Thanks for taking the time to read the blog about 39736-29-3

Reference£º
Thiazole | C3H8228NS – PubChem,
Thiazole | chemical compound | Britannica