Category: 399-74-6

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 334: Methyl 2-(3-(4-(6-fluorobenzo[d]thiazol-2-yloxy)phenyl)isoxazole-5- carboxamido)-3-methylbutanoate; To methyl 2-(3-(4-hydroxyphenyl)isoxazole-5-carboxamido)-3-methylbutanoate (200 mg) in N,N’ -Dimethyl formamide (4 ml), cesium carbonate (245 mg) was added and stirred for 15 -20 minutes. To this 2-chloro-6-fluorobenzo[d]thiazole (141 mg) was added and the reaction mixture was stirred at RT for 18 hours. Solvent was evaporated to obtain pale brown solid, which was purified by column chromatography (silica gel, EtOAc – CHCI3) to obtain off white solid, which was crystallized using DCM- Petroleum ether to obtain the title compound as white solid. Yield: 240 mg (81 %); MS (ES+): m/z 470 (M+l); 1HNMR (DMSOd6,300MHz): delta 9.27 (d, IH), 8.08 (d, 2H), 7.93 (dd, IH), 7.8 (s, IH), 7.74 (dd, IH), 7.67 (d, 2H),7.31 (m, IH), 4.33 (m, IH), 3.69 (s, 3H), 2.23 (m, IH), 0.98 (d, 6H)., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMAL LIFE SCIENCES LIMITED; GANGOPADHYAY, Ashok Kumar; KADAM, Kishorkumar, Shivajirao; JADHAV, Ravindra, Dnyandev; MISTRY, Hitesh; SHARMA, Rajiv; WO2010/23609; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-74-6,2-Chloro-6-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

Example 3: N-[(/5^25)-2-[(6-Fluoro-l<3-benzothiazol-2-vl)amino1cvclopentyl1-2<6- dimethoxybenzamide A microwave vial was charged N-((iS,2S)-2-aminocyclopentyl)-2,6-dimethoxybenzamide hydrochloride (Intermediate 11; 80 mg, 0.266 mmol), DIPEA (0.26 ml, 0.266 mmol) and 2-chloro-6-fluoro-l,3-benzothiazole (50 mg, 0.266 mmol) and the resulting mixture was heated with microwave irradiation at 250 C for 20 minutes. The reaction was purified by reverse phase preparative HPLC eluted with acetonitrile / water (with 0.1% ammonia) to afford the title compound.1H NMR (DMSO- e) delta ppm 1.48 - 1.77 (m, 4 H), 2.02 - 2.14 (m, 2 H), 3.62 (s, 6 H), 4.09 - 4.27 (m, 2 H), 6.51 - 6.65 (m, 2 H), 7.03-7.05 (m, 1 H), 7.18 - 7.38 (m, 2 H), 7.59 (m, 1 H) and 8.12-8.15 (m, 2 H)MS ES+: 416 399-74-6, The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Procedure: 50 mg, 0.33 mmol of benzo[c][1,2]oxaborol-1,5(3H)-diol was dissolved in 5 mL of N-methylpyrrolidine, then 75 mg, 0.40 mmol was added. 2-Chloro-6-fluorobenzothiazole and 162.9 mg, 0.5 mmol of cesium carbonate, the mixture was stirred at room temperature overnight, then treated with ammonium chloride, extracted with ethyl acetate, washed with brine, dried and concentrated. Purified by preparative high-performance liquid phase separation to give 5-(6-fluorobenzothiazol-2-oxy)benzo[c][1,2]oxaborol-1(3H)-ol, white solid 15 mg, yield 15%., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangzhou Baiting Pharmaceutical Technology Co., Ltd.; Wu Zhong; Li Jingrong; (16 pag.)CN108997394; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 21 (300 mg, 0.900 mmol,1.0 equiv) in n-butanol (5 ml) was added 2-chloro-6-fluorobenzo[d]thiazole (202 mg, 1.1 mmol, 1.1 equiv) and the reaction mixture was stirred at 70 C followed by the addition of 4.0 M HCl (131 mg). The resulting reaction mixture was stirred at 90 C for 16 h. Following reaction completion the solvent was removed under reduced pressure and the compound was purified by flash column chromatography using 10:90 EtOAc:Pet ether to yield methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate (130 mg, 29%) as a solid compound. To this butanoate ester (105 mg, 0.216 mmol) in THF (2 ml) was added 1.0 N lithium hydroxide solution (45 mg, 1.1 mmol,1.1 equiv) and the reaction mixture was stirred at rt for 4 h. Following reaction completion THF was removed under reduced pressure and dil. HCl was added to acidify the reaction mixture. The solid that precipitated as a result was filtered, washed with water,and dried to yield (70 mg, 68%) of the title compound as a white solid compound.

399-74-6, As the paragraph descriping shows that 399-74-6 is playing an increasingly important role.

Reference£º
Article; Kadam, Kishorkumar S.; Jadhav, Ravindra D.; Kandre, Shivaji; Guha, Tandra; Reddy, M. Mahesh Kumar; Brahma, Manoja K.; Deshmukh, Nitin J.; Dixit, Amol; Doshi, Lalit; Srinivasan, Shaila; Devle, Jayendra; Damre, Anagha; Nemmani, Kumar V. S.; Gupte, Amol; Sharma, Rajiv; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 337 – 347;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica